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Where to stay in Isle of Palms
Find the best Isle of Palms areas and neighborhoods for the activities you enjoy most. Learn more about Isle of Palms
Southside
3 out of top 10 points of interest in this area
If you're spending some time in Southside, St. Johns Town Center and The Avenues are top sights worth seeing.
Top hotels in Isle of Palms
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
4905 SAN PABLO ROAD SOUTH, Jacksonville, FL
Fully refundableReserve now, pay when you stay
The price is €181 per night from 14 Jul to 15 Jul
€181
per night
14 Jul - 15 Jul
9.2/10 Wonderful! (270 reviews)
Hope it is cleaner next time.
"We have stay at this hotel numerous times due to the convenience near Mayo Clinic. This is the first time that our room was not as clean as it should have been. Perhaps due to being a holiday weekend. Did mention it to the front desk. We will come back and give it another try. We are hopeful."
Reviewed on 28 May 2024
Margaritaville Jacksonville Beach
715 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
The price is €221 per night from 23 Jun to 24 Jun
€221
per night
23 Jun - 24 Jun
8.8/10 Excellent! (2,537 reviews)
"On beach, very cute"
Reviewed on 15 Jun 2024
Hampton Inn Jacksonville Beach/Oceanfront
1515 1st St N, Jacksonville Beach, FL
Fully refundableReserve now, pay when you stay
The price is €223 per night from 27 Jun to 28 Jun
€223
per night
27 Jun - 28 Jun
9/10 Wonderful! (1,547 reviews)
"We really enjoyed ourselves and it was very nice"
Reviewed on 12 Jun 2024
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Popular places to visit
Mayo Clinic Florida
If Mayo Clinic Florida is what brings you to town, hopefully you'll have a chance to explore more of Jacksonville.
Jacksonville Naval Air Station
After visiting Jacksonville Naval Air Station, make a plan to see the other sights and activities in Jacksonville. Experience the lively festivals or attend a sporting event in this family-friendly area.
EverBank Stadium
5/5(1 review)
Capable of seating over 80,000 fans, this modern football stadium is the exciting home of the Jacksonville Jaguars, international soccer games and music events.
Things to do
Self-Guided Kayaking: Real Florida Adventure
€42
Per adult
100% of travellers recommend
Amelia Island Area Kayak Rental on Lofton Creek with Adventures Up The Creek
€33
Per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.