Independent hotels in South San Francisco, San Francisco

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
12 Jun - 14 Jun
Next weekend
19 Jun - 21 Jun
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top South San Francisco Hotel Reviews

Handlery Union Square Hotel

Handlery Union Square Hotel

10/10 Excellent
"Great location in downtown SF. Footsteps away from many shops and restaurants. The staff was great and the beds were comfortable."
Peter 4-night trip
Posted less than an hour ago
Handlery Union Square Hotel