A large suspension bridge, industrial cranes, and a calm river.

5 Star Hotels in Panama Canal Zone, Panama

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Check availability on Panama Canal Zone 5 Star Hotels

Tonight
29 Aug - 30 Aug
Tomorrow
30 Aug - 31 Aug
Next weekend
4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

Our top choices for Panama Canal Zone 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.
A modern hotel room with a dining area, a TV, and a city view.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Lori
€125
includes taxes & fees
28 Sept - 29 Sept
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.
An outdoor seating area with wicker chairs and tables, large windows offering a city view at dusk.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
€251
includes taxes & fees
20 Sept - 21 Sept
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A spacious living room with a high ceiling, large windows, and a decorative ceiling fan.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Josh
€327
includes taxes & fees
20 Sept - 21 Sept
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.
A modern hotel entrance with a prominent 'Renaissance Hotel' sign, a well-lit outdoor area with a wooden structure, and a staircase leading to the upper floors.
The exterior of the Renaissance Hotel with a modern design, featuring a prominent 'R' logo, a geometric ceiling design, and a well-lit entrance area.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Tad Olivet Ottinger Welcome
€120
includes taxes & fees
11 Sept - 12 Sept
Renaissance Panama City Hotel
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A modern building with a sign reading 'HYATT REGENCY.'
A modern interior with a central seating area, potted plants, and a staircase.
A spacious lobby with a curved ceiling, a central staircase, and a reception desk.

5. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Deanna
€190
includes taxes & fees
30 Aug - 31 Aug
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.
A pool with a central water feature, surrounded by seating areas and potted plants.

6. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Maria Adriana Bravo
€254
includes taxes & fees
14 Sept - 15 Sept
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A modern living room with a city view, featuring a purple accent wall, a white sofa, and a glass table.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.
A high-rise building with a rooftop pool area, surrounded by other buildings.

7. W Panama

W Panama
Bella Vista
United States
Anna Lee
€218
includes taxes & fees
26 Sept - 27 Sept
W Panama
A poolside area with lounge chairs and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A modern building with a symmetrical facade, multiple balconies, and a central atrium with lighting.

8. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Benjamin A
€248
includes taxes & fees
20 Sept - 21 Sept
JW Marriott Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.
A spacious lobby with a large seating area, a reception desk, and large windows offering a view of the ocean and palm trees.

9. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Robert
€187
includes taxes & fees
25 Sept - 26 Sept
The Westin Playa Bonita Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A modern bar area with seating and a view of the city.
A modern interior with a spiral staircase, a large window, and a seating area.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.

10. Hilton Panama

Hilton Panama
Bella Vista
United States
William
€224
includes taxes & fees
18 Sept - 19 Sept
Hilton Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.
A person performing a yoga pose in a living room with a large window and a sofa.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Steven
€235
includes taxes & fees
6 Sept - 7 Sept
Bristol Panama, a Registry Collection Hotel

12. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
Megapolis Hotel Panamá

13. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
€105
includes taxes & fees
26 Sept - 27 Sept
Waymore Hotel Spa and Casino
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama Canal Zone.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
€125
27 Sept - 28 Sept
includes taxes & fees
8.6/10 Excellent! (2,685 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
€174
27 Sept - 28 Sept
includes taxes & fees
9.2/10 Wonderful! (1,007 reviews)
Central Hotel Panama Casco Viejo
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

Calle Augusto Samuel Boyd y Calle Eusebi Panama City
€104
1 Sept - 2 Sept
includes taxes & fees
9/10 Wonderful! (1,099 reviews)
Waymore Hotel Spa & Casino
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—rainforests, golf courses and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
A large steel bridge spanning a river with a cargo ship beneath it.

Top Panama Canal Zone Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"The breakfast was excellent and the staff was great. All in all, the hotel is an A+"
guy 7-night trip
Posted 10 hours ago
Hotel Riu Plaza Panama
Hyatt Regency Panama City

Hyatt Regency Panama City

10/10 Excellent
"Great place and great personal, hope to be back some time soon"
Fidel 3-night trip
Posted 13 hours ago
Hyatt Regency Panama City
Renaissance Panama City Hotel

Renaissance Panama City Hotel

10/10 Excellent
"I was very satisfied"
Jeffrey 4-night trip
Posted 4 days ago
Renaissance Panama City Hotel
Waldorf Astoria Panama

Waldorf Astoria Panama

10/10 Excellent
"Dede el ingress estuvimos super bien recibidos hasta el check in y en lahabitacion super bien el de say unto muy recommendable y gran atencion"
Gaudy 1-night trip
Posted 4 days ago
Waldorf Astoria Panama

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Panama Canal Zone?
The amount you pay for a 5-star hotel in Panama Canal Zone depends on things like when you plan to go and the length of your holiday. Our insider tip for bagging an awesome deal? Use our pricing filters to compare all of the available accommodation for your selected dates.
  • Search for the lowest price per night from €104
What makes a hotel 5 stars in Panama Canal Zone?
In Panama Canal Zone, a hotel must offer a specific number of upscale features to earn 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, premium bedding, complimentary luxury toiletries and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer extra touches such as a welcome gift.
Are there any 5-star all-inclusive resorts in Panama Canal Zone?
Expedia's filters are the quickest way to narrow down what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most luxurious hotels in Panama Canal Zone where your meals, room, entertainment and activities are included in the price. At these getaways, your holiday is pure extravagance from the moment you check in.