A large suspension bridge, industrial cranes, and a calm river.

5 Star Hotels in Panama Canal Zone, Panama

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Panama Canal Zone 5 Star Hotels

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Panama Canal Zone 5-star hotels

A rooftop pool with sun loungers and umbrellas, surrounded by palm trees and modern buildings.
A modern living room with a sofa set, a coffee table, and a dining area with chairs and a table.
A spacious lobby with a central seating area, a chandelier, and a modern ceiling design.
A hotel room with a bed, a TV, a desk, and a view of the cityscape through a window.

1. Hotel Riu Plaza Panama

Hotel Riu Plaza Panama
Bella Vista
United States
Yullando Abbigale
€130
includes taxes & fees
28 Oct - 29 Oct
Hotel Riu Plaza Panama
A person seated at a bar with a drink, in a room with a teal accent wall and hanging lights.
A tall, modern building with a prominent logo at the top, surrounded by other high-rise buildings in a cityscape.
A modern building with a rooftop lounge area, large windows, and a balcony overlooking a cityscape.
A modern interior with a decorative ceiling, a person in a white dress, and a blue-lit wall.

2. Waldorf Astoria Panama

Waldorf Astoria Panama
Bella Vista
United States
Aysha
€258
includes taxes & fees
31 Oct - 1 Nov
Waldorf Astoria Panama
A balcony with a table, chairs, and a view of a city skyline across a body of water.
A hotel with a rooftop pool, lounge chairs, and a view of the sea.
A spacious lobby with high ceilings, modern furniture, and decorative lighting fixtures.
A spacious lobby with a round coffee table, seating areas, and a large wall clock.

3. Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City
Casco Viejo
United States
Jose
€346
includes taxes & fees
3 Nov - 4 Nov
Sofitel Legend Casco Viejo, Panama City
A modern hotel room with a sofa, a coffee table, a TV mounted on the wall, and a dining area with a table and chairs.
A modern hotel entrance with a prominent 'Renaissance Hotel' sign, a well-lit outdoor area with a wooden structure, and a staircase leading to the upper floors.
An indoor swimming pool with lounge chairs and red chairs, surrounded by lush greenery and a modern interior design.
A modern lobby with a staircase, marble flooring, and large windows with tropical plants.

4. Renaissance Panama City Hotel

Renaissance Panama City Hotel
Bella Vista
United States
Carlos
€133
includes taxes & fees
31 Oct - 1 Nov
Renaissance Panama City Hotel
A poolside area with lounge chairs and a view of the ocean.
A modern bathroom with a large bathtub, two sinks, and a glass-enclosed shower area with a city view.
A terrace with seating and a view of the ocean.
A modern hotel room with a large bed, a chair, a nightstand with a lamp, and a view of the cityscape at dusk.

5. JW Marriott Panama

JW Marriott Panama
San Francisco
United States
Alberto
€275
includes taxes & fees
7 Nov - 8 Nov
JW Marriott Panama
A pool area with lounge chairs and umbrellas, surrounded by greenery and a multi-story building in the background.
A spacious lobby with a curved ceiling, a central staircase, and a reception desk.
A modern building with a sign reading 'HYATT REGENCY.'
A modern interior with a central seating area, potted plants, and a staircase.

6. Hyatt Regency Panama City

Hyatt Regency Panama City
Bella Vista
United States
Mariah
€184
includes taxes & fees
14 Nov - 15 Nov
Hyatt Regency Panama City
A hotel entrance with a central water feature, seating areas, and potted plants.
The entrance of The Santa Maria with a covered walkway and a view of the interior.
An outdoor dining area with wicker chairs and tables, a bar with bottles, and a pool in the background.
A spacious lobby with a wooden ceiling, a central wooden table surrounded by potted plants, and a marble wall with a large window in the background.

7. The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
Juan Diaz
United States
Carmen
€273
includes taxes & fees
1 Nov - 2 Nov
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
A modern restaurant with large windows offering a city view, warm lighting, and contemporary furniture.
A high-rise building with a rooftop pool area, surrounded by other buildings.
A modern high-rise building with a prominent 'W' logo, surrounded by other buildings and a busy street at night.
A modern hotel room with a large bed, a desk, a chair, and a view of the cityscape.

8. W Panama

W Panama
Bella Vista
United States
Naomi
€227
includes taxes & fees
7 Nov - 8 Nov
W Panama
A modern hotel pool area with lounge chairs and a clear view of the ocean.
A spacious lobby with a large seating area, a glass display case with bottles, and a view of the city at night.
A modern bar area with seating and a view of the city.
A modern interior with a spiral staircase, a large window, and a seating area.

9. Hilton Panama

Hilton Panama
Bella Vista
United States
Simon
€243
includes taxes & fees
6 Nov - 7 Nov
Hilton Panama
A hotel with a pool, beach, and palm trees.
A spacious lobby with a modern design, featuring a central seating area with sofas and ottomans, surrounded by large, open spaces and natural light.
A large hotel with multiple towers, a central courtyard with a swimming pool, and surrounding landscaped areas.
A beachfront hotel with a large building, a beach, and a clear sky.

10. The Westin Playa Bonita Panama

The Westin Playa Bonita Panama
Veracruz
United States
Lyman
€202
includes taxes & fees
25 Oct - 26 Oct
The Westin Playa Bonita Panama
A modern living room with a sofa, round black ottomans, and a vase of flowers. A cityscape is visible through the window.
A bar area with a long counter, multiple bar stools, and a television screen. There are large windows providing natural light and a view of the outdoors.
A rooftop swimming pool with a cityscape view, glass railings, and a modern architectural design.
A cozy outdoor seating area with a wooden bench and white tables, surrounded by lush greenery and potted plants.

11. Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel
Bella Vista
United States
Juliet
€208
includes taxes & fees
13 Nov - 14 Nov
Bristol Panama, a Registry Collection Hotel
Lobby
Banquet hall
Outdoor pool
Bar (on property)

12. Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino
Bella Vista
United States
Aldo
€101
includes taxes & fees
12 Nov - 13 Nov
Waymore Hotel Spa and Casino
Terrace/patio
Outdoor pool
Casino
Room

13. Megapolis Hotel Panamá

Megapolis Hotel Panamá
San Francisco
United States
MARVIN
€258
includes taxes & fees
5 Nov - 6 Nov
Megapolis Hotel Panamá
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Panama Canal Zone.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
€139
9 Nov - 10 Nov
includes taxes & fees
8.6/10 Excellent! (2,762 reviews)
Crowne Plaza Panama Airport by IHG
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
€248
26 Oct - 27 Oct
includes taxes & fees
9/10 Wonderful! (1,000 reviews)
Central Hotel Panama Casco Viejo
Megapolis Hotel Panamá

Megapolis Hotel Panamá

Avenida Balboa Panama City
€131
31 Oct - 1 Nov
includes taxes & fees
Megapolis Hotel Panamá
Still don't see what you're looking for?
See all properties in Panama Canal Zone.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Panama Canal Zone

Explore the relaxing area of Panama Canal Zone—rainforests, golf courses and popular sights like Albrook Shopping Mall.

See all hotels in Panama Canal Zone
A large suspension bridge, industrial cranes, and a calm river.

Top Panama Canal Zone Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

8/10 Good
"Breakfast buffet was generally good but there were not enough selections of cooked meats. Bacon was only offered twice during my visit and the other days the meat was like a hard hot dog."
Charles 5-night trip
Posted 4 hours ago
Hotel Riu Plaza Panama

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Panama Canal Zone?
The amount you pay for a 5-star hotel in Panama Canal Zone depends on things like when you plan to go and the length of your holiday. Our insider tip for bagging an awesome deal? Use our pricing filters to compare all of the available accommodation for your selected dates.
  • Search for the lowest price per night from €131
What makes a hotel 5 stars in Panama Canal Zone?
In Panama Canal Zone, a hotel must offer a specific number of upscale features to earn 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, premium bedding, complimentary luxury toiletries and more. What also sets 5-star hotels apart is their exceptional standard of service. You'll enjoy things like concierge services, nightly turn-down services and in-room massage. Some may even offer extra touches such as a welcome gift.
Are there any 5-star all-inclusive resorts in Panama Canal Zone?
Expedia's filters are the quickest way to narrow down what you're looking for. Check the "All inclusive" and "5-star" boxes to see the most luxurious hotels in Panama Canal Zone where your meals, room, entertainment and activities are included in the price. At these getaways, your holiday is pure extravagance from the moment you check in.