5 Star Hotels in Santiago, Santiago Metropolitan Region
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Santiago 5 Star Hotels
Our top choices for Santiago 5-star hotels
8.8 out of 10, Excellent, (1004)
"Nice hotel."
JORGE
The price is €115
22 Jan - 23 Jan 2026
9.2 out of 10, Wonderful, (943)
"Great hotel, staff, food, location, EVERYTHING! "
Mariano
The price is €216
10 Jan - 11 Jan 2026
The price is €236
17 Jan - 18 Jan 2026
9.4 out of 10, Exceptional, (593)
"The staff was fantastic!"
Kerry
The price is €263
10 Jan - 11 Jan 2026
8.6 out of 10, Excellent, (552)
"Excellent location and staff!"
Kelvin
The price is €166
1 Jan - 2 Jan 2026
9.6 out of 10, Exceptional, (681)
"The staff were wonderful and did a great job."
Muthukumarappan
The price is €327
20 Jan - 21 Jan 2026
9.0 out of 10, Wonderful, (911)
"Great location and wonderful and accommodating staff. "
Hillary
The price is €92
16 Jan - 17 Jan 2026
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santiago.
Holiday Inn Santiago - Airport Terminal by IHG
Armando Cortinez Norte 2150 Santiago Region Metropolitana
The price is €169 per night from 20 Jan to 21 Jan
€169
20 Jan - 21 Jan 2026
8.8/10 Excellent! (1,418 reviews)
Still don't see what you're looking for?
See all properties in Santiago.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Santiago and related destinations
Nestled between snow-capped Andes and coastal ranges, this vibrant capital rewards visitors with world-class museums and bustling markets at Plaza de Armas. Take the funicular up San Cristóbal Hill for panoramic city views, then explore bohemian Bellavista's colourful streets and sample wines at nearby Maipo Valley vineyards.
Top Santiago Hotel Reviews
Mandarin Oriental, Santiago
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- 4 Star Hotels in San Bernardo
- 5 Star Hotels in La Reina
- Accor Hotels in Barrio Brasil
- Barrio Brasil Hotels
- Lgbt-Friendly Hotels in Barrio Italia
- Barrio Italia Hotels
- Bellas Artes Hotels
- Casino Hotels in Bellavista
- Lgbt-Friendly Hotels in Bellavista
- Bellavista Hotels
- Buin Hotels
- Calera de Tango Hotels
- Cerrillos Hotels
- Cerro Navia Hotels
- Chicureo Hotels
- Hotels near Clinica Las Condes
- Hotels near Clinica Santa Maria
- Colina Hotels
- Hotels near Costanera Center
- Downtown Santiago Hotels
- Estación Central Hotels
- Hotels near Fantasilandia
- La Africana Hotels
- La Parva Hotels
- Las Condes Hotels
- Hotels with Parking in Lastarria
- Lastarria Hotels
- Lgbt-Friendly Hotels in Lo Hermida Abajo
- Lo Prado Hotels
- Hotels near Los Leones Golf Club
- Hotels with Spa in Maipo Valley
- Maipu Hotels
- Ñuñoa Hotels
- Paine Hotels
- Hotels near Palacio de la Moneda
- Hotels near Parque Arauco Mall
- Peñaflor Hotels
- Providencia Hotels
- Pudahuel Hotels
- Hotels near Puente Alto Plaza Station
- Puente Alto Hotels
- Quinta Normal Hotels
- Renca Hotels
- San Joaquín Hotels
- San José de Maipo Hotels
- Apartments in Santiago
- Hostels in Santiago
- Boutique Hotels in Santiago
- Cheap Hotels in Santiago
- Lgbt-Friendly Hotels in Santiago
- Luxury Hotels in Santiago
- Pet Friendly Hotels in Santiago
- Hotels with Spa in Santiago
- Santiago Hotels
- Hotels near Sernatur
- Talagante Hotels
- Valle Nevado Hotels
- Hotels near Vina Santa Carolina
- Vitacura Hotels
- Flights to Santiago
- Flights from Arturo Merino Benitez
- Flights from Auckland (AKL) to Santiago (SCL)
- Flights from Amsterdam (AMS) to Santiago (SCL)
- Flights from Paris (CDG) to Santiago (SCL)
- Flights from Dublin (DUB) to Santiago (SCL)
- Flights from London (LHR) to Santiago (SCL)
- Flights from Rio de Janeiro (RIO) to Santiago (SCL)
- Flights from Sydney (SYD) to Santiago (SCL)
- Bicentennial Park
- Cerro Pochoco Observatory
- Clinica Alemana
- Clinica Las Condes
- Concha Y Toro Winery
- Costanera Center
- Estadio Monumental David Arellano
- Fantasilandia
- Gran Torre Santiago
- La Cisterna Holidays
- Los Leones Golf Club
- Mall Plaza Los Dominicos
- Mall Plaza Oeste
- Mall Plaza Vespucio
- O'higgins Park
- Palacio de la Moneda
- Visit Pirque
- Pueblito Los Dominicos
- San Cristobal Hill
- Visit Las Condes
- Santiago Holidays
- Visit Santiago
- Sculpture Park
- University of Santiago-Chile