Alpine Hotel Guide - Big Bend Regional Medical Center hotels in Alpine, United States of America.

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31 Dec - 1 Jan
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1 Jan - 2 Jan
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for Big Bend Regional Medical Center hotels

Egyptian cotton sheets, premium bedding, memory-foam beds
Alpine Bed and Breakfast

Alpine Bed and Breakfast

Alpine Bed and Breakfast
4.0 star property
0.3 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (90)
"Awesome place to stay! "
United States
Isabel
The price is €184
includes taxes & fees
3 Jan - 4 Jan 2026
Alpine Bed and Breakfast
Interior
The Holland Hotel

The Holland Hotel

The Holland Hotel
3.0 star property
< 0.1 km from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (552)
"Everything --- absolutely excellent. "
United States
Tarai
The price is €106
includes taxes & fees
4 Jan - 5 Jan 2026
The Holland Hotel
Double Room
Antelope Lodge

Antelope Lodge

Antelope Lodge
3.5 star property
2.4 km from Big Bend Regional Medical Center
8.6 out of 10, Excellent, (587)
"Staff was very friendly!"
United States
Diane
The price is €110
includes taxes & fees
4 Jan - 5 Jan 2026
Antelope Lodge
Property grounds
The Maverick Inn

The Maverick Inn

The Maverick Inn
3.0 star property
1.3 km from Big Bend Regional Medical Center
8.2 out of 10, Very good, (450)
"Looks a little dated, but the rooms are comfortable and well furnished "
United States
steve
The price is €92
includes taxes & fees
4 Jan - 5 Jan 2026
The Maverick Inn
Signature Room
Alpine City Place

Alpine City Place

Alpine City Place
3.0 star property
0.1 km from Big Bend Regional Medical Center
8.0 out of 10, Very good, (84)
"We had a wonderful stay at this hotel. Everything was clean, comfortable, and well maintained, and the atmosphere was lovely. The location is unbeatable if you’re visiting the Big Bend area—perfectly situated and very convenient. We would definitely stay here again and highly recommend it."
United States
Aline
Alpine City Place
Restaurant
Americas Best Value Inn Alpine

Americas Best Value Inn Alpine

Americas Best Value Inn Alpine
2.5 star property
2.3 km from Big Bend Regional Medical Center
7.4 out of 10, Good, (570)
"Lighting is dim and the are no charging outlets for phones. Staff should have more knowledge of local restaurants."
United States
Nancy
The price is €106
includes taxes & fees
1 Jan - 2 Jan 2026
Americas Best Value Inn Alpine
Standard Room, 2 Double Beds, Non Smoking
Value Lodge

Value Lodge

Value Lodge
2.0 star property
2.3 km from Big Bend Regional Medical Center
7.4 out of 10, Good, (359)
"Friendly staff, great price, clean room, good location for the area. My 3 day stay was peaceful and enjoyable. "
United States
Clint
The price is €86
includes taxes & fees
25 Jan - 26 Jan 2026
Value Lodge
Desk, iron/ironing board, free cots/infant beds, free WiFi
Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine

Travelodge by Wyndham Alpine
2.0 star property
3 km from Big Bend Regional Medical Center
6.6 out of 10, (604)
"Was a very good stay"
United States
Jesse
The price is €118
includes taxes & fees
10 Jan - 11 Jan 2026
Travelodge by Wyndham Alpine
Lobby
OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park

OYO Alpine TX near Big Bend National Park
2.5 star property
0.9 km from Big Bend Regional Medical Center
4.8 out of 10, (498)
"Good experience at this property, clean and comfortable rooms, well maintained properly."
United States
Mallory
The price is €53
includes taxes & fees
31 Jan - 1 Feb 2026
OYO Alpine TX near Big Bend National Park
House | Interior
New The Cowboy Boots-shipping Container Home

New The Cowboy Boots-shipping Container Home

New The Cowboy Boots-shipping Container Home
2.0 star property
1.7 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (3)
"Good communication b4 and during stay. Very clean and on our way to natl park.."
United States
David
The price is €160
includes taxes & fees
27 Jan - 28 Jan 2026
New The Cowboy Boots-shipping Container Home
House
New The Wild West Cozy Container Home

New The Wild West Cozy Container Home

New The Wild West Cozy Container Home
2.0 star property
1.9 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (3)
"5 Stars all the way. Highly recommend and would stay here again. The rooftop access was perfect for stargazing."
United States
Brenda
The price is €181
includes taxes & fees
27 Jan - 28 Jan 2026
New The Wild West Cozy Container Home
House
New Longhorn Stunning Container Home-in Alpine

New Longhorn Stunning Container Home-in Alpine

New Longhorn Stunning Container Home-in Alpine
3.0 star property
2 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (2)
The price is €203
includes taxes & fees
27 Jan - 28 Jan 2026
New Longhorn Stunning Container Home-in Alpine
House
New Southwest Shipping Container-in Alpine

New Southwest Shipping Container-in Alpine

New Southwest Shipping Container-in Alpine
3.0 star property
2 km from Big Bend Regional Medical Center
9.0 out of 10, Wonderful, (2)
"Everything we needed was provided. Coffee, shampoo, soap and lotions. Enjoyed the rooftop deck at night for star gazing."
United States
Jay
The price is €234
includes taxes & fees
9 Jan - 10 Jan 2026
New Southwest Shipping Container-in Alpine
House
New Moonlight Ridge-shipping Container Home

New Moonlight Ridge-shipping Container Home

New Moonlight Ridge-shipping Container Home
3.0 star property
1.8 km from Big Bend Regional Medical Center
10.0 out of 10, Exceptional, (1)
The price is €186
includes taxes & fees
27 Jan - 28 Jan 2026
New Moonlight Ridge-shipping Container Home
House
Somewhere in Texas Container Home

Somewhere in Texas Container Home

Somewhere in Texas Container Home
2.0 star property
1.7 km from Big Bend Regional Medical Center
8.0 out of 10, Very good, (2)
"We really enjoyed our stay. We found the container home very comfortable, clean with everything we needed. We liked the observation deck only thing there is that the light from Alpine took away from our ability to view the stars.in every direction. Its still a good deal."
United States
Kimberly
The price is €215
includes taxes & fees
5 Jan - 6 Jan 2026
Somewhere in Texas Container Home
House
New Cowgirl Shipping Container Home

New Cowgirl Shipping Container Home

New Cowgirl Shipping Container Home
2.0 star property
1.7 km from Big Bend Regional Medical Center
The price is €165
includes taxes & fees
27 Jan - 28 Jan 2026
New Cowgirl Shipping Container Home
House
Adobe Vista - Cozy and Inviting Spectacular View

Adobe Vista - Cozy and Inviting Spectacular View

Adobe Vista - Cozy and Inviting Spectacular View
2.0 star property
1 km from Big Bend Regional Medical Center
The price is €241
includes taxes & fees
4 Jan - 5 Jan 2026
Adobe Vista - Cozy and Inviting Spectacular View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Big Bend Regional Medical Center Hotel Reviews

Hampton Inn Alpine

Hampton Inn Alpine

10/10 Excellent
"The room was super clean and the staff was amazing!"
Maria de los Angeles 1-night trip
Posted 3 days ago
Hampton Inn Alpine

Hotels near other Big Bend Regional Medical Center attractions

Kiowa Gallery

3.8/5 (19 reviews)
You can spend an afternoon exploring the galleries in Kiowa Gallery in Alpine. Wander around the parks or enjoy the area's restaurants.
See properties

Museum of the Big Bend

4.5/5 (95 reviews)
You can spend an afternoon browsing the exhibits at Museum of the Big Bend in Alpine. Wander around the parks or enjoy the area's restaurants.
See properties

Frequently asked questions

What's the area like around Big Bend Regional Medical Center?
Big Bend Regional Medical Center is located in Alpine. Travellers like the surrounding area for its parks. If you're looking for a convenient place to stay, take a look at the 51 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay near Big Bend Regional Medical Center?
Adjacent to Big Bend Regional Medical Center, The Holland Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers free parking and free WiFi. Other good choices within a short distance include OYO Alpine TX near Big Bend National Park and Alpine City Place.
How many hotels should I expect to find near Big Bend Regional Medical Center?
Expedia has 51 hotels and other accommodation options within a mile from Big Bend Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Big Bend Regional Medical Center, will I receive a refund?
Yes! The majority of room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within 24 hours of your booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer near Big Bend Regional Medical Center.
What can I see and do near Big Bend Regional Medical Center?
You might spend a leisurely day outdoors at Kokernot Municipal Park and Shipman Park. Attractions like Kiowa Gallery and Museum of the Big Bend highlight the local culture. You might plan a visit to Kokernot Field or Alpine Municipal Pool while you're in the area.