Mount Pleasant Hotel Guide - East Cooper Medical Center hotels in Mount Pleasant, United States of America.

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Our top choices for East Cooper Medical Center hotels

Lobby sitting area
Cambria Hotel Mount Pleasant – Charleston

Cambria Hotel Mount Pleasant – Charleston

Cambria Hotel Mount Pleasant – Charleston
3.0 star property
2.3 km from East Cooper Medical Center
9.4 out of 10, Exceptional, (1816)
"Beautiful room, good staff"
United States
Queen
The price is €91
includes taxes & fees
4 Jan - 5 Jan 2026
Cambria Hotel Mount Pleasant – Charleston
Reception
Tru by Hilton Mt Pleasant Charleston

Tru by Hilton Mt Pleasant Charleston

Tru by Hilton Mt Pleasant Charleston
2.5 star property
2 km from East Cooper Medical Center
9.2 out of 10, Wonderful, (1459)
"It was a great hotel!"
United States
Alashia
The price is €88
includes taxes & fees
3 Jan - 4 Jan 2026
Tru by Hilton Mt Pleasant Charleston
Lobby
Hyatt House Charleston / Mount Pleasant

Hyatt House Charleston / Mount Pleasant

Hyatt House Charleston / Mount Pleasant
3.5 star property
2.4 km from East Cooper Medical Center
9.2 out of 10, Wonderful, (1000)
"Good value and great location."
United States
Howard
The price is €105
includes taxes & fees
3 Jan - 4 Jan 2026
Hyatt House Charleston / Mount Pleasant
Courtyard
Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms

Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms

Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms
2.5 star property
0.3 km from East Cooper Medical Center
9.0 out of 10, Wonderful, (1003)
"Great place to stay!!!"
United States
Fredrick
The price is €89
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms
Free daily on-the-go breakfast
Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG

Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG

Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG
2.5 star property
0.8 km from East Cooper Medical Center
9.0 out of 10, Wonderful, (1000)
"Everything about my stay here has been a delight, clean room, professional & friendly staff "
United States
John
The price is €90
includes taxes & fees
4 Jan - 5 Jan 2026
Holiday Inn Express & Suites Charleston NE Mt Pleasant US17 by IHG
Exterior
Home2 Suites By Hilton Mt Pleasant Charleston

Home2 Suites By Hilton Mt Pleasant Charleston

Home2 Suites By Hilton Mt Pleasant Charleston
3.0 star property
0.7 km from East Cooper Medical Center
8.8 out of 10, Excellent, (1006)
"Variety of breakfast options - hotel and room felt clean overall - lots of dining options nearby "
United States
Sarah
The price is €94
includes taxes & fees
2 Jan - 3 Jan 2026
Home2 Suites By Hilton Mt Pleasant Charleston
Free daily full breakfast
Residence Inn by Marriott Charleston Mount Pleasant

Residence Inn by Marriott Charleston Mount Pleasant

Residence Inn by Marriott Charleston Mount Pleasant
3.0 star property
0.4 km from East Cooper Medical Center
8.8 out of 10, Excellent, (183)
"Property was quiet and clean. It was convenient to dining and shopping options. Pool was very well maintained and breakfast was well-stocked and excellent each morning. "
United States
Holly
The price is €123
includes taxes & fees
28 Dec - 29 Dec
Residence Inn by Marriott Charleston Mount Pleasant
Property amenity
Courtyard by Marriott Charleston Mount Pleasant

Courtyard by Marriott Charleston Mount Pleasant

Courtyard by Marriott Charleston Mount Pleasant
3.0 star property
1.9 km from East Cooper Medical Center
8.8 out of 10, Excellent, (1000)
"We had a very restful stay. The lady that checked us in was very nice. The room was very clean and the beds were comfortable. "
United States
Kathryn
The price is €97
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard by Marriott Charleston Mount Pleasant
Free daily buffet breakfast
Homewood Suites by Hilton Charleston - Mt Pleasant

Homewood Suites by Hilton Charleston - Mt Pleasant

Homewood Suites by Hilton Charleston - Mt Pleasant
3.0 star property
1.5 km from East Cooper Medical Center
8.4 out of 10, Very good, (1000)
"Courteous staff and great location"
United States
Loushon
The price is €104
includes taxes & fees
31 Dec - 1 Jan 2026
Homewood Suites by Hilton Charleston - Mt Pleasant
Exterior
Comfort Suites at Isle Of Palms Connector

Comfort Suites at Isle Of Palms Connector

Comfort Suites at Isle Of Palms Connector
2.5 star property
0.5 km from East Cooper Medical Center
8.2 out of 10, Very good, (1003)
"The staff was friendly and the room was exceptionally clean. "
United States
RAYMOND
The price is €85
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites at Isle Of Palms Connector
Exterior detail
Post House Inn

Post House Inn

Post House Inn
3.5 star property
Old Village Historical District, 6.8 km from East Cooper Medical Center
10.0 out of 10, Exceptional, (63)
"We loved our stay at the Inn! "
United States
Jennifer
Post House Inn
Rooftop terrace
The Loutrel

The Loutrel

The Loutrel
4.0 star property
11 km from East Cooper Medical Center
10.0 out of 10, Exceptional, (1001)
"Beautiful hotel in a great location "
United States
Sean
The Loutrel
2 Charles | Living area
Beautiful Renovated Apartment Near King Street

Beautiful Renovated Apartment Near King Street

Beautiful Renovated Apartment Near King Street
3.5 star property
11.6 km from East Cooper Medical Center
10.0 out of 10, Exceptional, (5)
"Very clean, bright. Very comfortable bed, nice shower and amenities. Also convenient to our venue - within walking distance to our activities."
United States
Anonymous traveller
The price is €468
includes taxes & fees
22 Dec - 23 Dec
Beautiful Renovated Apartment Near King Street
Microwave, coffee/tea maker, high chair, blender
Hilton Club Liberty Place Charleston

Hilton Club Liberty Place Charleston

Hilton Club Liberty Place Charleston
3.5 star property
10.7 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (889)
"Wonderful two bedroom suite and room was cleaned daily - wonderful location as well."
United States
Liz
The price is €207
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Club Liberty Place Charleston
View from property
HarbourView Inn

HarbourView Inn

HarbourView Inn
4.0 star property
10.8 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (1003)
"Clean and spacious room, excellent staff and "treats," and great location - can walk to almost everything."
United States
Nancy
HarbourView Inn
Anson Suite
Zero George Street

Zero George Street

Zero George Street
5.0 star property
10.8 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (354)
"A delightful stay in a delightful setting. "
United States
Tommy
The price is €266
includes taxes & fees
5 Jan - 6 Jan 2026
Zero George Street
Front of property
The Spectator Hotel

The Spectator Hotel

The Spectator Hotel
4.0 star property
11 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (985)
"Excellent 5 star hotel"
United States
John
The Spectator Hotel
Front of property
French Quarter Inn

French Quarter Inn

French Quarter Inn
4.0 star property
11.1 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (1004)
"Phenomenal stay - highly recommend"
United States
Patricia
French Quarter Inn
Terrace/patio
The Pinch Hotel

The Pinch Hotel

The Pinch Hotel
4.0 star property
11.3 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (171)
"Wonderful stay at The Pinch! The staff is lovely, friendly and helpful. They were able to offer us an upgrade, and the accommodations are well-designed with high-end finishes. Absolutely recommend! "
United States
Heather
The Pinch Hotel
Terrace/patio
The Nickel Hotel

The Nickel Hotel

The Nickel Hotel
4.0 star property
11.4 km from East Cooper Medical Center
9.8 out of 10, Exceptional, (82)
"Beautiful hotel!! Close to shopping and dining! Highly recommended!!"
United States
Matthew
The price is €219
includes taxes & fees
5 Jan - 6 Jan 2026
The Nickel Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top East Cooper Medical Center Hotel Reviews

Cambria Hotel Mount Pleasant – Charleston

Cambria Hotel Mount Pleasant – Charleston

10/10 Excellent
"Nice spot"
Joshua 3-night trip
Posted 6 days ago
Cambria Hotel Mount Pleasant – Charleston

Hotels near other East Cooper Medical Center attractions

Boone Hall Plantation and Gardens

4.6/5 (518 reviews)
Find out about the history of Mount Pleasant with a stop at Boone Hall Plantation and Gardens. Stroll along the area's waterfront or simply savour its top-notch restaurants.
See properties

Regal Palmetto Grande

You can take time to visit Regal Palmetto Grande during your travels to Mount Pleasant. Wander the area's riverfront or simply enjoy one of its top-notch restaurants.
See properties

Frequently asked questions

What's the area like around East Cooper Medical Center?
East Cooper Medical Center is located in Mount Pleasant. This historic area is known for its stunning river views and array of dining options. If you're looking for a convenient place to stay, take a look at the 24 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to East Cooper Medical Center?
Adjacent to East Cooper Medical Center, Hyatt Place Mount Pleasant Towne Centre is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and a restaurant. Other good options close by include Home2 Suites By Hilton Mt Pleasant Charleston and Hampton Inn & Suites Charleston/Mt. Pleasant-Isle Of Palms.
How many hotels will I find close to East Cooper Medical Center?
Expedia has 24 hotels and other accommodation options within a mile from East Cooper Medical Center.
If I need to cancel the hotel reservation for my stay near East Cooper Medical Center, will I receive a refund?
Yes, you'll find most hotel bookings are refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to view the best deals available near East Cooper Medical Center.
What can I see and do near East Cooper Medical Center?
Learn about local history at Charles Pinckney National Historic Site and Pitt Street Bridge. You can enjoy live performances at Crabpot Players Theatre and Cinebarre Mount Pleasant. Spend some time wandering around Shem Creek Park, Mount Pleasant Memorial Waterfront Park and Palmetto Islands County Park.