A historic stone fortress with arched windows and a central tower.

Eastern Sicily Hotel Guide - Luxury Hotels in Eastern Sicily, Italy

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Eastern Sicily Luxury Hotels

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Eastern Sicily luxury hotels

A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.

1. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
5.0 star property
Ortigia
9.2 out of 10, Wonderful, (111 reviews)
  • cleanliness
    Discover the epitome of Mediterranean luxury steps from Ortigia's coastline at this spa-focused retreat with poolside indulgence.
The price is €691
includes taxes & fees
30 Oct - 31 Oct
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A bedroom with a large bed, a desk, and a chair, with a view of the countryside through large windows.

2. Monaci delle Terre Nere

Monaci delle Terre Nere
5.0 star property
Zafferana Etnea
9.4 out of 10, Exceptional, (71 reviews)
  • cleanliness
    Sicilian paradise offers vineyard views, spa indulgence, outdoor pool, and gourmet dining in Zafferana Etnea.
The price is €979
includes taxes & fees
28 Oct - 29 Oct
Monaci delle Terre Nere
A covered entrance with a wooden door, stone columns, and hanging lanterns.

3. Grand Hotel Timeo, A Belmond Hotel, Taormina

Grand Hotel Timeo, A Belmond Hotel, Taormina
5.0 star property
Taormina City Centre
9.8 out of 10, Exceptional, (222 reviews)
  • cleanliness
    Sicilian elegance graces this boutique hotel with Michelin dining, spa sanctuary, and scenic pool near Greek Theatre.
The price is €956
includes taxes & fees
3 Nov - 4 Nov
Grand Hotel Timeo, A Belmond Hotel, Taormina
A resort with a pool, palm trees, and a view of the ocean.

4. The Ashbee Hotel - The Leading Hotels of the World

The Ashbee Hotel - The Leading Hotels of the World
5.0 star property
Taormina
9.4 out of 10, Exceptional, (155 reviews)
  • cleanliness
    Luxury awaits at this art deco gem in Taormina, with rooftop dining and poolside elegance.
The price is €752
includes taxes & fees
30 Oct - 31 Oct
The Ashbee Hotel - The Leading Hotels of the World
A glass-enclosed hot tub with a view of the sea, surrounded by lush greenery and a palm tree.

5. Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts

Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts
5.0 star property
Taormina
9.2 out of 10, Wonderful, (298 reviews)
  • cleanliness
    Sicilian elegance meets spa luxury at this 5-star retreat with panoramic dining and poolside indulgence.
The price is €642
includes taxes & fees
11 Nov - 12 Nov
Grand Hotel San Pietro Taormina - Preferred Hotels & Resorts
A rooftop pool area with lounge chairs and umbrellas, surrounded by lush greenery and a mountain in the background.

6. San Domenico Palace, Taormina, A Four Seasons Hotel

San Domenico Palace, Taormina, A Four Seasons Hotel
5.0 star property
Taormina City Centre
9.4 out of 10, Exceptional, (316 reviews)
  • cleanliness
    Timeless elegance at San Domenico Palace with 3 restaurants, spa services, and a poolside retreat in Taormina.
The price is €1,490
includes taxes & fees
2 Nov - 3 Nov
San Domenico Palace, Taormina, A Four Seasons Hotel
A seaside patio with wicker furniture, a stone floor, and a view of the sea.

7. Mazzarò Sea Palace - The Leading Hotels of the World

Mazzarò Sea Palace - The Leading Hotels of the World
5.0 star property
Mazzaro
9.6 out of 10, Exceptional, (341 reviews)
  • cleanliness
    Exclusive beachfront luxury awaits at this Mazzaro haven with private beach access, full-service spa, and stunning sea views.
The price is €581
includes taxes & fees
13 Nov - 14 Nov
Mazzarò Sea Palace - The Leading Hotels of the World
An aerial view of a rocky island with clear waters, a beach, and a small building.

8. Hotel Villa Ducale

Hotel Villa Ducale
4.0 star property
Taormina
9.8 out of 10, Exceptional, (362 reviews)
  • cleanliness
    Mediterranean luxury by the sea with rooftop terrace and ocean-view dining in Sicily.
The price is €556
includes taxes & fees
28 Oct - 29 Oct
Hotel Villa Ducale
A spa room with a large window, a hot tub, and two candles.

9. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
5.0 star property
Syracuse
9.4 out of 10, Exceptional, (223 reviews)
  • cleanliness
    Coastal luxury awaits at this five-star retreat offering a full-service spa, two outdoor pools, and Mediterranean dining near Fanusa Beach.
The price is €327
includes taxes & fees
1 Nov - 2 Nov
Dimora Caiammari Luxury Hotel & Spa
A large swimming pool with a modern building in the background.

10. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
5.0 star property
Syracuse
9.4 out of 10, Exceptional, (99 reviews)
  • cleanliness
    Sicilian spa escape boasts 2 outdoor pools and a serene full-service wellness centre.
The price is €320
includes taxes & fees
15 Nov - 16 Nov
Wellness & Spa Hotel Principe di Fitalia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Eastern Sicily Hotel Reviews

San Domenico Palace, Taormina, A Four Seasons Hotel

San Domenico Palace, Taormina, A Four Seasons Hotel

10/10 Excellent
"Best hotel ever. It is beautiful. Everything is provided, including things you never knew you needed! I literally cannot praise this hotel enough. We will be returning without a doubt."
Yasmin 3-night trip
Posted 20 hours ago
San Domenico Palace, Taormina, A Four Seasons Hotel