A long bridge spanning a river, surrounded by lush greenery and fields.

Greenville Hotel Guide - Hotels with Spa in Greenville, Mississippi

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Check availability on Greenville Hotels with Spa

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Greenville hotels with a spa

A salon setting with two people seated, a table with various skincare products, a vase with flowers, and neatly rolled towels in the background.
A spacious lobby with a grand chandelier, a round seating area, and a second-floor balcony.
A person sitting by a pool with clear blue water, wearing a white bikini and a large straw hat.
A restaurant with multiple dining areas, including booths and tables, with overhead lighting and a bar in the background.

1. Harlow's Casino Resort & Spa

Harlow's Casino Resort & Spa
Greenville
  • Relax in riverside luxury with spa treatments featuring hot stone massages, aromatherapy, and deep-tissue therapies in spacious suites.
€114
includes taxes & fees
13 Oct - 14 Oct
Harlow's Casino Resort & Spa
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
5 stars

Top Greenville Hotel Reviews

Frequently asked questions

Looking to holiday at a spa hotel in Greenville?
Forget the stress of everyday life and book yourself a lush spa hotel. Enjoy the live music scene and restaurants in Greenville—your day trip starts here. Enjoy the entertainment choices and riverfront during your holiday. Spa hotels are the perfect way to take a break from your daily routine and add a layer of luxury to your stay.
What is the best spa hotel in Greenville?
Harlow's Casino Resort & Spa is a top spa hotel featuring 3 restaurants, 3 bars, a casino and a 24-hour fitness centre. Enjoy a facial, body scrub or detox wrap at the on-site spa.
How many spa hotels are there in Greenville?
Among Expedia's 18 accommodation options in Greenville, there is 1 spa hotel.
What's there to see and do in Greenville?
Take in some sights and attractions while you're in Greenville by visiting Trop Casino Greenville, Greenville Country Club and Harlow's Casino Resort & Spa. If you have a bit of extra time while you're in the area, you might want to check out Mississippi River and 1927 Flood Museum.
What is a Greenville spa hotel?
Spa hotels in Greenville feature on-site spas offering services such as couples massages and a selection of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are ideal if you are looking for some R&R during your holiday.