Mediterranean Region Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €900 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top Flight + Hotel Deals in Mediterranean Region

Price found within the past 48 hours. Click for updated prices.
Hotel Delle Civette

Hotel Delle Civette

Nomentano
Save 100% on your flight
€201
per person
11 Dec - 13 Dec
found 1 day ago
Return flight included
Dublin (DUB) to Rome (FCO)
9.6/10 Exceptional! (323 reviews)
Relais de la Poste

Relais de la Poste

Rome City Centre
€252
per person
30 Nov - 3 Dec
found 1 day ago
Return flight included
Athens (ATH) to Rome (FCO)
9.2/10 Wonderful! (734 reviews)
This was a very nice hotel to stay. The staff were great, the rooms were clean and it was centrally located to everything.

Reviewed on 7 Oct 2026

Hotel Le Petit

Hotel Le Petit

Rome City Centre
€386
per person
23 Nov - 26 Nov
found 1 day ago
Return flight included
Athens (ATH) to Rome (FCO)
9/10 Wonderful! (20 reviews)
The hotel is beautiful and in a fantastic location near city center and the train station which made travel between other cities very easy. Almost everything we wanted to see was within walking distance distance. There are a huge variety of restaurants near by. The hotel is beautiful and clean. The staff is very welcoming.

Reviewed on 4 Oct 2026

Hotel Centro Cavour

Hotel Centro Cavour

Rome City Centre
€415
per person
16 Nov - 20 Nov
found 1 day ago
Return flight included
Athens (ATH) to Rome (FCO)
9.2/10 Wonderful! (1,005 reviews)
Hotel Maximus

Hotel Maximus

Rome City Centre
€492
per person
23 Nov - 26 Nov
found 1 day ago
Return flight included
Athens (ATH) to Rome (FCO)
9.2/10 Wonderful! (69 reviews)
A very nice hotel. Friendly and helpful staff. Close to many attractions in the city centre area. Close to hop on hop off buses. Lots of restaurants all around the area. Good shopping as well. Would definitely stay there again if visiting Rome.

Reviewed on 1 Oct 2026

Where to stay in Mediterranean Region

Find the best Mediterranean Region areas and neighborhoods for the activities you enjoy most. Learn more about Mediterranean Region
A historic building with a dome and columns, surrounded by pedestrians and parked vehicles.

Rome City Centre

Trevi Fountain and Piazza Navona are a few top attractions in Rome City Centre. Hop around the city on the metro at Venezia Tram Stop or Arenula-Cairoli Tram Station and check out the area's fascinating museums, stunning cathedral and stunning river views.

A busy urban street with historic buildings, a clock tower, and a bus.

Madrid Centro

Known for its fascinating museums and acclaimed art galleries, there's plenty to explore in Madrid Centro. Check out top attractions like Puerta del Sol and Gran Via, and jump on the metro at Sol Station or Gran Via Station to see more of the city.

A cityscape with a prominent stone wall and a view of the city below.

Lisbon City Center

Avenida da Liberdade and Rossio Square are top sights in Lisbon City Center, and you should be sure to explore the popular shops. Hop aboard the metro at Saldanha Station or Sao Sebastiao Station to see more sights in the area.

A historic cathedral with a tall bell tower and intricate architectural details.

Downtown Barcelona

Known for its fascinating museums, stunning cathedral and popular shops, there's plenty to explore in Downtown Barcelona. Top attractions like La Rambla and Plaça de Catalunya are major draws. Catch the metro at Liceu Station or Jaume I Station to see more of the city.

A classical building with columns and statues, surrounded by well-maintained hedges and a clear blue sky.

Athens City Centre

Known for its fascinating museums, charming cafes and popular shops, there's plenty to explore in Athens City Centre. Top attractions like Acropolis and Syntagma Square are major draws. Catch the metro at Panepistimio Station or Syntagma Station to see more of the city.

Top hotels in Mediterranean Region

Hotel101- Madrid

Hotel101- Madrid

Av. de las Fuerzas Armadas, 328 Madrid
Fully refundableReserve now, pay when you stay
€85
12 Oct - 13 Oct
includes taxes & fees
9.4/10 Exceptional! (1,625 reviews)
"Es un buen hotel... Y es económico no llega a 100$ la noche comparándolo con otros hoteles en el centro...si llegas antes las 10pm T buscan del aeropuerto y t llevan al aeropuerto... El tren/metro estas a menos d 5 minutos a pie..con 3.50€ llegas al centro rápido.... No tienes pq pagar los 33 euros ..."

Reviewed on 8 Oct 2026

Hotel101- Madrid
Barcelona Airport Hotel

Barcelona Airport Hotel

Plaza de la Volateria, 3 El Prat de Llobregat
Fully refundableReserve now, pay when you stay
€176
1 Nov - 2 Nov
includes taxes & fees
8.6/10 Excellent! (5,189 reviews)
"I travel a lot and have stayed in many hotels worldwide. I rarely write reviews for anything. However, on this occasion I am compelled to warn others to give this hotel a very wide berth. The front desk staff were rude and aggressive, irritated that I didn't produce a passport immediately upon arrival, ..."

Reviewed on 7 Oct 2026

Barcelona Airport Hotel
Regnum The Crown - All inclusive

Regnum The Crown - All inclusive

Tasliburun Mevkii Serik Antalya
€1,235
13 Oct - 14 Oct
includes taxes & fees
Regnum The Crown - All inclusive
See all 807,302 properties in Mediterranean Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Mediterranean Region attractions

The Colosseum in Rome with tourists around.

Colosseum

9.4/10 (44,408 reviews)
A true architectural heavyweight, the 2,000-year-old Colosseum is often considered one of the seven “modern” wonders of the world.
See properties
A cityscape at dusk with historic buildings, a prominent Rolex store, and a busy street.
Photo by National Tourist Office of Spain

Gran Via

9.4/10 (23,455 reviews)
Madrid’s famous shopping strip has boutiques and international brands, an exciting nightlife and an impressive display of early 20th-century architecture.
See properties
The Sagrada Familia with a construction crane in the foreground.

Sagrada Familia

9.4/10 (32,723 reviews)
Gaudí’s basilica in the center of Barcelona is an architectural marvel and offers views across the city from eight towering spires.
See properties
The Trevi Fountain with sculptures and a large archway.

Trevi Fountain

9.2/10 (43,482 reviews)
Rome is a city abundant in world-class water features, but none more stunning, or more famous, than the Trevi Fountain.
See properties
A coastal cityscape at dusk with illuminated buildings, a marina, and a prominent fortress-like structure.

Port of Civitavecchia

8.6/10 (754 reviews)
Explore the waterfront in Civitavecchia with a trip to Port of Civitavecchia. Wander the area's seaside or simply enjoy one of its top-notch restaurants.
See properties
A cityscape with autumn foliage, a prominent building with a clock tower, and a distant mountain range.

La Rambla

8.8/10 (31,278 reviews)
These lively pedestrian streets in the heart of Barcelona are filled with flower stalls, tapas restaurants and street performers.
See properties
A large neoclassical building with columns and the inscription "MAGRIPPA COSTERTIVI".

Pantheon

9.4/10 (37,189 reviews)
One of ancient Rome’s greatest achievements combines momentous history and inspired architecture.
See properties
A historic church with twin bell towers and a central obelisk, surrounded by a crowd of people on the steps.

Spanish Steps

9.2/10 (37,743 reviews)
A monumental stairway with a monumental past, the Spanish Steps are literally and figuratively at the heart of Rome.
See properties
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.