Palmdale Hotel Guide - Palmdale Regional Medical Center hotels in Palmdale, United States of America.

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Tonight
19 Dec - 20 Dec
Tomorrow
20 Dec - 21 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Palmdale Regional Medical Center hotels

Terrace/patio
DoubleTree by Hilton Palmdale, CA

DoubleTree by Hilton Palmdale, CA

DoubleTree by Hilton Palmdale, CA
4.0 star property
1.1 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (764)
"Great Service and staff."
United States
leticia
The price is €75
includes taxes & fees
28 Dec - 29 Dec
DoubleTree by Hilton Palmdale, CA
Lobby
Element Palmdale

Element Palmdale

Element Palmdale
3.0 star property
1.5 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (631)
"Staff was really friendly and accommodating! "
United States
Jose L
The price is €91
includes taxes & fees
2 Jan - 3 Jan 2026
Element Palmdale
Lobby
Fairfield Inn & Suites by Marriott Palmdale West

Fairfield Inn & Suites by Marriott Palmdale West

Fairfield Inn & Suites by Marriott Palmdale West
2.5 star property
3 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (485)
"Rooms are great. Beds are comfortable!"
United States
Lori
The price is €100
includes taxes & fees
21 Dec - 22 Dec
Fairfield Inn & Suites by Marriott Palmdale West
Individually furnished, desk, laptop workspace, blackout curtains
Home2 Suites by Hilton Palmdale, CA

Home2 Suites by Hilton Palmdale, CA

Home2 Suites by Hilton Palmdale, CA
3.0 star property
0.8 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (390)
"Very friendly staff, clean spacious rooms, and close to everything may need."
United States
Greg
The price is €85
includes taxes & fees
9 Jan - 10 Jan 2026
Home2 Suites by Hilton Palmdale, CA
Reception
Embassy Suites Palmdale

Embassy Suites Palmdale

Embassy Suites Palmdale
3.5 star property
1.6 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (1111)
"Great location"
United States
Juan
The price is €103
includes taxes & fees
30 Dec - 31 Dec
Embassy Suites Palmdale
Lobby
Residence Inn Palmdale Lancaster

Residence Inn Palmdale Lancaster

Residence Inn Palmdale Lancaster
3.0 star property
2.3 km from Palmdale Regional Medical Center
9.0 out of 10, Wonderful, (381)
"Great staff, clean rooms, restaurants are very close by !"
United States
Greg
The price is €115
includes taxes & fees
23 Dec - 24 Dec
Residence Inn Palmdale Lancaster
Exterior
Holiday Inn Palmdale-Lancaster by IHG

Holiday Inn Palmdale-Lancaster by IHG

Holiday Inn Palmdale-Lancaster by IHG
3.0 star property
0.8 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1001)
"Enjoyed my stay…very clean and spacious, staff was attentive…and location was great and safe."
United States
Roxana
The price is €89
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Palmdale-Lancaster by IHG
Lobby
Courtyard Palmdale

Courtyard Palmdale

Courtyard Palmdale
3.0 star property
2.3 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (929)
"Spotless room , great staff! "
United States
Sandra
The price is €96
includes taxes & fees
22 Dec - 23 Dec
Courtyard Palmdale
Bar (on property)
Hilton Garden Inn Palmdale

Hilton Garden Inn Palmdale

Hilton Garden Inn Palmdale
3.0 star property
2.3 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1000)
"Room was clean, staff was great!!"
United States
Cecilia
The price is €91
includes taxes & fees
28 Dec - 29 Dec
Hilton Garden Inn Palmdale
Exterior
Best Western Plus John Jay Inn & Suites

Best Western Plus John Jay Inn & Suites

Best Western Plus John Jay Inn & Suites
2.5 star property
0.5 km from Palmdale Regional Medical Center
8.6 out of 10, Excellent, (1002)
"Always a great place to stay. "
United States
Julio
The price is €94
includes taxes & fees
26 Dec - 27 Dec
Best Western Plus John Jay Inn & Suites
Exterior
Staybridge Suites Palmdale by IHG

Staybridge Suites Palmdale by IHG

Staybridge Suites Palmdale by IHG
3.0 star property
0.8 km from Palmdale Regional Medical Center
8.4 out of 10, Very good, (586)
"The staff is very friendly the room was cozy and the breakfast was delicious "
United States
Julio
The price is €109
includes taxes & fees
30 Dec - 31 Dec
Staybridge Suites Palmdale by IHG
Free daily continental breakfast
Hampton Inn & Suites Palmdale

Hampton Inn & Suites Palmdale

Hampton Inn & Suites Palmdale
2.5 star property
2 km from Palmdale Regional Medical Center
8.4 out of 10, Very good, (1000)
"Good place "
United States
Julio
The price is €75
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Palmdale
Front of property
Woodspring Suites Palmdale - Lancaster

Woodspring Suites Palmdale - Lancaster

Woodspring Suites Palmdale - Lancaster
2.5 star property
3 km from Palmdale Regional Medical Center
8.4 out of 10, Very good, (174)
"This is one of the best places to stay away from home."
United States
Terenia
The price is €80
includes taxes & fees
21 Dec - 22 Dec
Woodspring Suites Palmdale - Lancaster
Desk, free WiFi, bed sheets
Palms Inn & Suites

Palms Inn & Suites

Palms Inn & Suites
2.5 star property
0.8 km from Palmdale Regional Medical Center
6.8 out of 10, (1123)
"I really enjoyed my stay."
United States
Anna
Palms Inn & Suites
Lobby
Red Roof Inn Palmdale - Lancaster

Red Roof Inn Palmdale - Lancaster

Red Roof Inn Palmdale - Lancaster
2.0 star property
1.4 km from Palmdale Regional Medical Center
5.0 out of 10, (1000)
"Very nice at check in"
United States
Christina
The price is €63
includes taxes & fees
21 Dec - 22 Dec
Red Roof Inn Palmdale - Lancaster
Room, 1 King Bed
OYO Hotel Palmdale - Antelope Valley

OYO Hotel Palmdale - Antelope Valley

OYO Hotel Palmdale - Antelope Valley
2.0 star property
1.8 km from Palmdale Regional Medical Center
5.0 out of 10, (310)
"It was a good stay for a 24-hour period"
United States
Paul
The price is €67
includes taxes & fees
1 Jan - 2 Jan 2026
OYO Hotel Palmdale - Antelope Valley
Property amenity
Fairfield Inn & Suites by Marriott Lancaster Palmdale

Fairfield Inn & Suites by Marriott Lancaster Palmdale

Fairfield Inn & Suites by Marriott Lancaster Palmdale
2.5 star property
11.1 km from Palmdale Regional Medical Center
9.4 out of 10, Exceptional, (668)
"Have stayed here for the 2nd time and it has been great! "
United States
Maria
The price is €101
includes taxes & fees
23 Dec - 24 Dec
Fairfield Inn & Suites by Marriott Lancaster Palmdale
Property amenity
Residence Inn by Marriott Lancaster Palmdale

Residence Inn by Marriott Lancaster Palmdale

Residence Inn by Marriott Lancaster Palmdale
3.0 star property
12.8 km from Palmdale Regional Medical Center
9.4 out of 10, Exceptional, (279)
"Clean room, great staff! "
United States
Janet
The price is €135
includes taxes & fees
25 Dec - 26 Dec
Residence Inn by Marriott Lancaster Palmdale
Terrace/patio
TownePlace Suites by Marriott Lancaster, CA

TownePlace Suites by Marriott Lancaster, CA

TownePlace Suites by Marriott Lancaster, CA
3.0 star property
11.3 km from Palmdale Regional Medical Center
9.2 out of 10, Wonderful, (349)
"Wonderful hotel."
United States
david
The price is €118
includes taxes & fees
27 Dec - 28 Dec
TownePlace Suites by Marriott Lancaster, CA
Front of property
Oxnard Inn Lancaster

Oxnard Inn Lancaster

Oxnard Inn Lancaster
3.0 star property
10.4 km from Palmdale Regional Medical Center
8.8 out of 10, Excellent, (1002)
"Always a nice and affordable stay."
United States
Amanda
The price is €85
includes taxes & fees
27 Dec - 28 Dec
Oxnard Inn Lancaster
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Palmdale Regional Medical Center Hotel Reviews

Triplodge of Santa Clarita

Triplodge of Santa Clarita

10/10 Excellent
"Not bad for 1 night."
Dexter 1-night trip
Posted 2 days ago
Triplodge of Santa Clarita

Hotels near other Palmdale Regional Medical Center attractions

I <3 this place! I hope I can find w place like this back in WA!
Photo by Christine Buggs
Open Photo by Christine Buggs

Antelope Valley Mall

4.1/5 (133 reviews)
You can find the perfect gifts to bring home at Antelope Valley Mall during your stay in Palmdale. Visit the shops and top-notch restaurants in this family-friendly area.
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Panoramic image looking east of Palmdale in Los Angeles county showing the California aqueduct in the foreground.

Lake Palmdale

4.1/5 (36 reviews)
Commune with nature and explore the great outdoors at Lake Palmdale during your travels in Palmdale. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
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Frequently asked questions

What's the area like around Palmdale Regional Medical Center?
Palmdale Regional Medical Center is located in a welcoming area of Palmdale known for its array of dining options. If you're looking for a convenient place to stay, take a look at the 28 hotels and other accommodation options you'll find within a mile.
What's the best place to stay near Palmdale Regional Medical Center?
DoubleTree by Hilton Palmdale, CA is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. It's located just a short 0.7 mi (1.1 km) from Palmdale Regional Medical Center. Another good choice is Embassy Suites Palmdale, located 1 mi (1.6 km) away.
How many hotels should I expect to find close to Palmdale Regional Medical Center?
Expedia has 28 hotels and other accommodation options within a mile from Palmdale Regional Medical Center.
If I need to cancel the hotel reservation for my stay near Palmdale Regional Medical Center, will I receive a refund?
Yes! The majority of room reservations are refundable provided that you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to get the best deals near Palmdale Regional Medical Center.
What can I see and do near Palmdale Regional Medical Center?
You can enjoy live performances at Palmdale Playhouse and Palmdale Amphitheater. If you have some time to wander around the area, you might stop by Antelope Valley Country Club, Rancho Vista Golf Club or Cinemark Antelope Valley Mall. If you want to see more of the surrounding area, you can plan a visit to Antelope Valley Mall and Palmdale City Hall.