A coastal town with a pier, boats, and a hillside with buildings.

Pythagorio Hotel Guide - Luxury Hotels in Pythagorio, Samos

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Check availability on Pythagorio Luxury Hotels

Tonight
20 Aug - 21 Aug
Tomorrow
21 Aug - 22 Aug
This weekend
21 Aug - 23 Aug
Next weekend
28 Aug - 30 Aug

Our top choices for Pythagorio luxury hotels

1. Casa Cook Samos

Casa Cook Samos
Samos
  • Beachfront luxury meets spa indulgence at Casa Cook Samos, where Mediterranean elegance awaits.
€344
includes taxes & fees
29 Aug - 30 Aug
Casa Cook Samos

2. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
  • Relish beachfront luxury at this Samos seaside resort where warm staff, 2 outdoor pools, and a private beach create an indulgent escape.
€245
includes taxes & fees
18 Sept - 19 Sept
Doryssa Seaside Resort

3. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
  • Private beachfront luxury meets seaside serenity at this adults-only Samos resort offering spa indulgences and ocean-view dining.
€226
includes taxes & fees
30 Aug - 31 Aug
Proteas Blu Resort - Adults Only

4. Hydrele Beach Hotel

Hydrele Beach Hotel
Samos
€163
includes taxes & fees
1 Sept - 2 Sept
Hydrele Beach Hotel

5. Doryssa Theorem Hotel

Doryssa Theorem Hotel
Samos
€206
includes taxes & fees
31 Aug - 1 Sept
Doryssa Theorem Hotel

6. Doryssa Boutique Hotel

Doryssa Boutique Hotel
Samos
€193
includes taxes & fees
28 Aug - 29 Aug
Doryssa Boutique Hotel

7. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
€347
includes taxes & fees
19 Sept - 20 Sept
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

8. Arion Hotel

Arion Hotel
Samos
€181
includes taxes & fees
18 Sept - 19 Sept
Arion Hotel

9. Samian Mare Hotel Suites & Spa

Samian Mare Hotel Suites & Spa
Samos
€155
includes taxes & fees
21 Aug - 22 Aug
Samian Mare Hotel Suites & Spa

10. Erato by Samian Mare

Erato by Samian Mare
Samos
€198
includes taxes & fees
22 Aug - 23 Aug
Erato by Samian Mare
View all properties

Top Pythagorio Hotel Reviews

Doryssa Seaside Resort

Doryssa Seaside Resort

10/10 Excellent
"Loved this place so much. The pool was excellent, breakfast delicious, restaurants real good and plenty of them for choices. The property is very beautiful. We had the deluxe garden view which I recommend. We only stood 3 nights but I would stay longer next time and one day we took a ferry to Turkey for a day trip to Ephesus which was fantastic. You would need to rent a car if you want to sightsee the island as well."
Christine 3-night trip
Posted 5 days ago
Doryssa Seaside Resort
Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only

8/10 Good
"Inner architecture is not good, rooms are good and clean, staff are really nice and helpful. I bought sea view room but it was not that much sea view it was more like concrete view, Beach and pool side are quite nice Breakfast was very good"
ercan 1-night trip
Posted 7 days ago
Proteas Blu Resort - Adults Only

Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Pythagorio?
During your visit, you might want to enjoy the port which Pythagorio is known for.
What's the best luxury hotel in Pythagorio?
Casa Cook Samos is a luxury hotel with a beachfront restaurant and 2 bars, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Proteas Blu Resort - Adults Only and Doryssa Seaside Resort are other upscale choices for your trip.
When can I expect good weather in Pythagorio?
Planning for the weather is an important factor for making your trip to Pythagorio a success, especially when you're splurging. The hottest months are usually August and July, with an average temperature of 25°C, while the coldest months are January and February, with an average of 13°C. Average annual precipitation for Pythagorio is 837 mm.
What's there to see and do in Pythagorio?
Experience Pythagorio with a stop at Samos Pythagorion Archaeological Museum, Pythagoreion and Castle of Lycurgus. If you have spare time during your trip, you might want to make a stop at Tunnel of Eupalinos and Glicorisa Beach.