A coastal town with a pier, boats, and a hillside with buildings.

Pythagorio Hotel Guide - Hotels with Spa in Pythagorio, Samos

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Check availability on Pythagorio Hotels with Spa

Tonight
4 Oct - 5 Oct
Tomorrow
5 Oct - 6 Oct
Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Our top choices for Pythagorio hotels with a spa

A modern interior with a central seating area, a kitchen in the background, and large windows.
A modern living room with a sofa, wooden side tables, a round ottoman, and a dining area with chairs and a kitchen in the background.
An outdoor cafe with tables, chairs, potted plants, and a tree with ripe oranges.
A modern bathroom with a glass-enclosed shower, a marble-tiled wall, a sink with a mirror, and neatly stacked towels.

1. Doryssa Theorem Hotel

Doryssa Theorem Hotel
Samos
  • Serene massages await at this eco-certified urban retreat with a steam room and rainfall showers for ultimate relaxation.
€116
includes taxes & fees
5 Oct - 6 Oct
Doryssa Theorem Hotel
A massage therapy session in an outdoor setting with a scenic view of the sea and mountains.
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A beach with rows of sunbeds and thatched umbrellas, a clear blue sea, and mountains in the background.
A modern hotel room with a white sofa, a glass coffee table with cups, a blue desk, and a view of the sea through large windows.

2. Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
  • Seaside retreat offers rejuvenating spa treatments, private beach access, and indoor-outdoor pools.
€177
includes taxes & fees
5 Oct - 6 Oct
Proteas Blu Resort - Adults Only
A person in a colorful swimsuit standing on a balcony overlooking the ocean.
A coastal residential area with multi-story buildings, a swimming pool, and a view of the sea and a mountain in the distance.
A modern living room with a sofa, armchair, and a TV mounted on the wall.
A balcony with a table set for breakfast, including a basket, a plate of pastries, a cup, and a potted plant.

3. Hydrele Beach Hotel

Hydrele Beach Hotel
Samos
  • Revitalise with beachside spa services and seasonal pool at this coastal retreat with Turkish hammam and sauna.
€106
includes taxes & fees
6 Oct - 7 Oct
Hydrele Beach Hotel
A modern bathroom with a stone-patterned wall, a glass bathtub, and a small seating area with a kettle and cups.
A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A hotel room with a bed, a sofa, a dining table, and a view of the sea.

4. Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
  • Rejuvenate at this beachfront hotel with a full-service spa and seaside yoga classes for total relaxation.
€197
includes taxes & fees
5 Oct - 6 Oct
Doryssa Seaside Resort
A pool area with steps leading into the water, a bench, and a stone wall.
A room with a view of the sea through sheer curtains, a wooden bed, and a balcony with a chair and a table.
A beachside resort with outdoor seating areas, umbrellas, and a view of the sea.
A bar area with a wooden counter and stools.

5. Casa Cook Samos

Casa Cook Samos
Samos
  • Immerse in a beachfront boutique escape with 4 specialised treatment rooms and daily aromatherapy spa services for complete renewal.
€221
includes taxes & fees
21 Oct - 22 Oct
Casa Cook Samos
A poolside lounge area with wooden pergolas and stone walls.
A wooden deck with lounge chairs and a pool.
A pool area with lounge chairs and umbrellas, surrounded by stone walls and greenery.
A bedroom with a wooden wall, a hanging textured light fixture, and a bed with pillows.

6. Doryssa Boutique Hotel

Doryssa Boutique Hotel
Samos
  • Indulge in rejuvenating spa treatments at this boutique hotel with seasonal pool and garden oasis.
€135
includes taxes & fees
5 Oct - 6 Oct
Doryssa Boutique Hotel
A modern outdoor terrace with a pool, seating, and a view of a coastal town.
A bar area with stools, a counter, and bottles.
A modern multi-story house with a flat roof, large windows, and a landscaped terrace with water features.
A modern interior with a dark wood reception desk, a sofa, a large abstract painting, and a potted plant.

7. Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)

Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
Samos
€168
includes taxes & fees
23 Oct - 24 Oct
Nirema Hotel & Spa Samos - MGallery Collection (opening Q3 2026)
A poolside area with lounge chairs and an umbrella, overlooking a clear blue sea and distant mountains.
A bedroom with a bed, a large mirror, and an open door leading to a balcony with a view of the sea.
A balcony with a view of a coastal area, including a beach and a mountainous backdrop.
A terrace with a view of the sea and a mountainous landscape.

8. Armonia Bay Hotel

Armonia Bay Hotel
Samos
  • Mediterranean retreat offers rejuvenating seaside escapes with massages, infinity pools, and garden serenity.
€134
includes taxes & fees
14 Oct - 15 Oct
Armonia Bay Hotel
A circular seating area with mosaic tile walls and a central pillar.
A reception area with a wooden reception desk, a clock, and a reception sign.
A buffet setup with various food items and serving utensils.
A pool area with lounge chairs and umbrellas, surrounded by buildings with balconies and a clear sky.

9. Aegeon

Aegeon
Samos
  • Unwind at this island hotel with tranquil spa treatments, including massage services in 2 treatment rooms and a relaxing Turkish bath.
€67
includes taxes & fees
5 Oct - 6 Oct
Aegeon
A spacious lobby with a marble floor, white sofas, and potted plants.
A wooden deck with lounge chairs and a thatched umbrella.
A pool area with a wooden pergola structure, a clear night sky, and a mountain backdrop.
An outdoor dining area with wicker furniture, a bar with shelves of bottles, and a view of trees and mountains in the background.

10. Samian Mare Hotel Suites & Spa

Samian Mare Hotel Suites & Spa
Samos
  • Serene beachfront escape with two outdoor pools and an on-site spa offering rejuvenating treatments in scenic surroundings.
€88
includes taxes & fees
7 Oct - 8 Oct
Samian Mare Hotel Suites & Spa
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Choose what matters most at spa hotels in Pythagorio

Pool
Breakfast included
Hot tub
4 stars
5 stars

Spa hotels with pools in Pythagorio

A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A poolside table with a meal, a drink, and a view of a pool and mountains.
A coastal hotel with a swimming pool, surrounded by greenery and overlooking the sea.

Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
€197
includes taxes & fees
5 Oct - 6 Oct
Doryssa Seaside Resort
A modern resort with a central pool, lounge areas, and mountain views.
A bar area with a wooden counter and stools.
A beachside resort with outdoor seating areas, umbrellas, and a view of the sea.
A spa area with two massage tables, a stone floor, and a bamboo partition.

Casa Cook Samos

Casa Cook Samos
Samos
€221
includes taxes & fees
21 Oct - 22 Oct
Casa Cook Samos
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A serene outdoor setting with a pool, a person in a white dress, and a view of the sea.
A covered outdoor seating area with wooden flooring, white cushioned chairs, and tables.
A modern bedroom with a bed, bedside tables, a desk, and a view of the sea.

Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
€177
includes taxes & fees
5 Oct - 6 Oct
Proteas Blu Resort - Adults Only
A person in a colorful swimsuit standing on a balcony overlooking the ocean.
A coastal residential area with multi-story buildings, a swimming pool, and a view of the sea and a mountain in the distance.
A buffet area with a variety of food options, including a section labeled "Pastry" and another labeled "Bacon."
A beach with clear blue water, a sandy shore, and a few boats. There are buildings with colorful roofs in the background.

Hydrele Beach Hotel

Hydrele Beach Hotel
Samos
€106
includes taxes & fees
6 Oct - 7 Oct
Hydrele Beach Hotel
A pool area with lounge chairs and umbrellas, surrounded by stone walls and greenery.
A bedroom with a wooden wall, a hanging textured light fixture, and a bed with pillows.
A wooden deck with lounge chairs and a pool.
A modern reception desk with a wooden surface, a computer, and a vase with flowers. There are chairs and a staircase in the background.

Doryssa Boutique Hotel

Doryssa Boutique Hotel
Samos
€135
includes taxes & fees
5 Oct - 6 Oct
Doryssa Boutique Hotel
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Spa hotels with free breakfast in Pythagorio

An outdoor cafe with tables, chairs, potted plants, and a tree with ripe oranges.
A modern living room with a sofa, wooden side tables, a round ottoman, and a dining area with chairs and a kitchen in the background.
A spa area with a hot tub, two bean bag chairs, and several potted plants.
A modern kitchen with dark cabinetry, a central island, and two chairs.

Doryssa Theorem Hotel

Doryssa Theorem Hotel
Samos
€116
includes taxes & fees
5 Oct - 6 Oct
Doryssa Theorem Hotel
A beach with rows of beige lounge chairs and umbrellas, a clear sky, and a calm sea with a distant mountain.
A beachside lounge with white umbrellas and beige lounge chairs, a wooden deck, and a view of the sea and a pier in the background.
A poolside table with a meal, a drink, and a view of a pool and mountains.
A coastal hotel with a swimming pool, surrounded by greenery and overlooking the sea.

Doryssa Seaside Resort

Doryssa Seaside Resort
Samos
€197
includes taxes & fees
5 Oct - 6 Oct
Doryssa Seaside Resort
A row of wooden beach umbrellas with white cushions on a sandy beach, overlooking the sea.
A serene outdoor setting with a pool, a person in a white dress, and a view of the sea.
A covered outdoor seating area with wooden flooring, white cushioned chairs, and tables.
A modern bedroom with a bed, bedside tables, a desk, and a view of the sea.

Proteas Blu Resort - Adults Only

Proteas Blu Resort - Adults Only
Samos
€177
includes taxes & fees
5 Oct - 6 Oct
Proteas Blu Resort - Adults Only
A person in a colorful swimsuit standing on a balcony overlooking the ocean.
A coastal residential area with multi-story buildings, a swimming pool, and a view of the sea and a mountain in the distance.
A buffet area with a variety of food options, including a section labeled "Pastry" and another labeled "Bacon."
A beach with clear blue water, a sandy shore, and a few boats. There are buildings with colorful roofs in the background.

Hydrele Beach Hotel

Hydrele Beach Hotel
Samos
€106
includes taxes & fees
6 Oct - 7 Oct
Hydrele Beach Hotel
A modern resort with a central pool, lounge areas, and mountain views.
A bar area with a wooden counter and stools.
A beachside resort with outdoor seating areas, umbrellas, and a view of the sea.
A spa area with two massage tables, a stone floor, and a bamboo partition.

Casa Cook Samos

Casa Cook Samos
Samos
€221
includes taxes & fees
21 Oct - 22 Oct
Casa Cook Samos
A pool area with lounge chairs and umbrellas, surrounded by stone walls and greenery.
A bedroom with a wooden wall, a hanging textured light fixture, and a bed with pillows.
A wooden deck with lounge chairs and a pool.
A modern reception desk with a wooden surface, a computer, and a vase with flowers. There are chairs and a staircase in the background.

Doryssa Boutique Hotel

Doryssa Boutique Hotel
Samos
€135
includes taxes & fees
5 Oct - 6 Oct
Doryssa Boutique Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Pythagorio Hotel Reviews

Doryssa Seaside Resort

Doryssa Seaside Resort

10/10 Excellent
"A gorgeous property, great location, courteous staff… would def stay there again!! Perfect room!!😊"
Athanasios 2-night trip
Posted 8 days ago
Doryssa Seaside Resort

Frequently asked questions

Looking for a spa hotel in Pythagorio?
Treat yourself to some pampering and book a hotel with a spa. Discover the historical sites and museums in Pythagorio—your cultural tour starts here. Make sure you pay a visit to the monuments during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Pythagorio?
Casa Cook Samos is a top beach spa hotel featuring a fitness centre, a hair salon, a beach bar and a restaurant. Treat yourself to a facial, body scrub or Swedish massage at the on-site spa. In-room massages are also available. Other popular spa hotels in Pythagorio include Proteas Blu Resort - Adults Only and Doryssa Seaside Resort.
How many spa hotels are there in Pythagorio?
Among Expedia's 74 accommodation options in Pythagorio, there are 5 spa hotels.
What's there to see and do in Pythagorio?
Take in the sights and attractions that Pythagorio offers with a visit to Samos Pythagorion Archaeological Museum, Pythagoreion and Glicorisa Beach. If you have extra time while you're in the area, you might want to stop by Tunnel of Eupalinos and Potakaki beach.
What is a Pythagorio spa hotel?
Spa hotels in Pythagorio feature on-site spas and offer services including couples massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation and relaxation.