Chamberlain Hotel Guide - Sanford Chamberlain Medical Center hotels in Chamberlain, United States of America.

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Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Sanford Chamberlain Medical Center hotels

Lobby
AmericInn by Wyndham Chamberlain - Conference Center

AmericInn by Wyndham Chamberlain - Conference Center

AmericInn by Wyndham Chamberlain - Conference Center
2.5 star property
1.6 km from Sanford Chamberlain Medical Center
8.6 out of 10, Excellent, (1001)
"Very clean, staff is great"
United States
Thomas
The price is €97
includes taxes & fees
10 Jan - 11 Jan 2026
AmericInn by Wyndham Chamberlain - Conference Center
Desk, laptop workspace, blackout curtains, free WiFi
Super 8 by Wyndham Chamberlain SD

Super 8 by Wyndham Chamberlain SD

Super 8 by Wyndham Chamberlain SD
2.0 star property
2.6 km from Sanford Chamberlain Medical Center
8.2 out of 10, Very good, (1001)
"Clean room and friendly staff."
United States
Deborah
The price is €71
includes taxes & fees
5 Jan - 6 Jan 2026
Super 8 by Wyndham Chamberlain SD
Exterior
Best Western Lee's Motor Inn

Best Western Lee's Motor Inn

Best Western Lee's Motor Inn
2.5 star property
2.8 km from Sanford Chamberlain Medical Center
8.2 out of 10, Very good, (996)
"Clean and big room! Friendly staff good breakfast "
United States
Anna
The price is €94
includes taxes & fees
5 Jan - 6 Jan 2026
Best Western Lee's Motor Inn
Single Room, 1 King Bed
A Bridge View Inn

A Bridge View Inn

A Bridge View Inn
2.0 star property
2.9 km from Sanford Chamberlain Medical Center
8.2 out of 10, Very good, (513)
"Good place to stay"
United States
Violeta
The price is €57
includes taxes & fees
26 Dec - 27 Dec
A Bridge View Inn
Room (2 Queen Bed & 1 Full Bed) | Room amenity
Hotel O Bel Aire Chamberlain SD I 90

Hotel O Bel Aire Chamberlain SD I 90

Hotel O Bel Aire Chamberlain SD I 90
2.0 star property
2.5 km from Sanford Chamberlain Medical Center
7.2 out of 10, Good, (112)
"Clean, warm, cozy."
United States
Dmitri
The price is €58
includes taxes & fees
28 Dec - 29 Dec
Hotel O Bel Aire Chamberlain SD I 90
Indoor pool, open 6 AM to 11 PM, pool loungers
Baymont by Wyndham Oacoma

Baymont by Wyndham Oacoma

Baymont by Wyndham Oacoma
2.5 star property
4.9 km from Sanford Chamberlain Medical Center
8.8 out of 10, Excellent, (1000)
"We had a great stay at the Baymont: clean rooms and facilities, comfortable beds, quiet and everything we needed."
United States
Dan
The price is €97
includes taxes & fees
26 Dec - 27 Dec
Baymont by Wyndham Oacoma
Exterior
Howard Johnson Hotel & Suites by Wyndham Oacoma

Howard Johnson Hotel & Suites by Wyndham Oacoma

Howard Johnson Hotel & Suites by Wyndham Oacoma
2.0 star property
5.8 km from Sanford Chamberlain Medical Center
8.6 out of 10, Excellent, (1001)
"Very clean rooms and pool areas. Staff was very friendly, price was great. Just overall a wonderful stay"
United States
Marin
The price is €87
includes taxes & fees
5 Jan - 6 Jan 2026
Howard Johnson Hotel & Suites by Wyndham Oacoma
Marina
Cedar Shore Resort

Cedar Shore Resort

Cedar Shore Resort
3.0 star property
5 km from Sanford Chamberlain Medical Center
8.2 out of 10, Very good, (1000)
"Felt like home"
United States
Janine
The price is €108
includes taxes & fees
5 Jan - 6 Jan 2026
Cedar Shore Resort
Exterior
Quality Inn Oacoma - Chamberlain

Quality Inn Oacoma - Chamberlain

Quality Inn Oacoma - Chamberlain
2.5 star property
6 km from Sanford Chamberlain Medical Center
8.2 out of 10, Very good, (540)
"Very nice quaint hotel"
United States
Amber
The price is €76
includes taxes & fees
27 Dec - 28 Dec
Quality Inn Oacoma - Chamberlain
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sanford Chamberlain Medical Center Hotel Reviews

Hotel O Bel Aire Chamberlain SD I 90

Hotel O Bel Aire Chamberlain SD I 90

10/10 Excellent
"Clean, comfortable room"
Heidi 1-night trip
Posted 11 days ago
Hotel O Bel Aire Chamberlain SD I 90

Hotels near other Sanford Chamberlain Medical Center attractions

Dignity Statue

4.7/5 (19 reviews)
You can find out about the history of Chamberlain with a trip to Dignity Statue. Stroll along this family-friendly area's riverfront or simply enjoy its bars.
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Lewis and Clark Interpretive and Keelboat Center

4.6/5 (34 reviews)
You can spend an afternoon exploring the galleries in Lewis and Clark Interpretive and Keelboat Center during your trip to Chamberlain. Stroll along this family-friendly area's riverfront or simply enjoy its bars.
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Frequently asked questions

What's the area like around Sanford Chamberlain Medical Center?
Sanford Chamberlain Medical Center is located in Chamberlain. Travellers like this family-friendly area for its riverfront and bars. You'll find 29 hotels and other accommodations within a few miles for a convenient home base.
What's the best hotel to stay close to Sanford Chamberlain Medical Center?
AmericInn by Wyndham Chamberlain - Conference Center is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. It's located 1 mi (1.6 km) from Sanford Chamberlain Medical Center. Other good choices within a few miles include Super 8 by Wyndham Chamberlain SD and Howard Johnson Hotel & Suites by Wyndham Oacoma.
How many hotels will I find close to Sanford Chamberlain Medical Center?
Expedia has 29 hotels and other accommodation options a few miles from Sanford Chamberlain Medical Center.
If I need to cancel the hotel reservation for my stay near Sanford Chamberlain Medical Center, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best deals available near Sanford Chamberlain Medical Center.
What can I see and do near Sanford Chamberlain Medical Center?
You'll want to browse the exhibits at Akta Lakota Museum And Cultural Center and South Dakota Hall Fame. You might spend a leisurely day outdoors at South Dakota Veterans Park and Roam Free Park. Dignity Statue and Chamberlain Marina are both worth a visit while you're out exploring.