A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Hotel Guide - Luxury Hotels in Santa Cruz, Santa Cruz

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Santa Cruz Luxury Hotels

Tonight
13 Oct - 14 Oct
Tomorrow
14 Oct - 15 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

Our top choices for Santa Cruz luxury hotels

A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.
A spacious lobby with high ceilings, large windows, and a modern chandelier.
A hot tub with a wooden deck and stone walls, surrounded by a pool.
A restaurant with a long counter, dark chairs, and hanging lights.

1. Camino Real Hotel

Camino Real Hotel
Santa Cruz
  • Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
€156
30 Oct - 31 Oct
Camino Real Hotel
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.
A modern lobby with a curved staircase, seating area, and a large wooden bookshelf.
A restaurant with a high ceiling, large windows, and a view of the cityscape. Tables are set with plates, glasses, and cutlery.
A modern lobby with a dining area, sofas, and a decorative wall.

2. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
  • Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
€94
1 Nov - 2 Nov
Marriott Santa Cruz de la Sierra Hotel
A spacious room with a wooden floor and large windows offering a city view.
A modern lobby with marble reception desks, a staircase, and decorative hanging lights.
A hotel room with two beds, a nightstand, and a wall-mounted lamp.
A buffet table with various food items and a wine bottle.

3. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in spa treatments, outdoor pool relaxation, and friendly concierge service at this entertainment district luxury retreat.
€117
1 Nov - 2 Nov
Swissôtel Santa Cruz De La Sierra
A spacious lobby with large windows, modern chandeliers, and a seating area with sofas and chairs.
A hotel room with two beds, a nightstand, a lamp, and a view of the city.
A spacious lobby with a high ceiling, modern furniture, and a central seating area.
A window seat with a view of a cityscape at dusk.

4. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in art deco elegance at this Santa Cruz hotel with luxurious pools and concierge service.
€115
25 Oct - 26 Oct
Novotel Santa Cruz De La Sierra
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.
A hotel room with a large bed, a desk, a chair, a telephone, and a view of the city through large windows.
A hotel with a prominent 'Hampton' sign, large windows, and a modern facade.
A modern hotel lobby with a bar area, seating arrangements, and a television.

5. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
  • Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
€66
15 Oct - 16 Oct
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A hotel room with a bed, a desk with a chair, a television, and a window with a city view.
A lobby with a marble floor, an elevator, and a view of the outdoor seating area.
A gym with various exercise equipment, including a treadmill, weight machines, and a bench.
A corridor with tiled flooring, potted plants, and a view of a building with a thatched roof.

6. Gran Hotel Santa Cruz

Gran Hotel Santa Cruz
Centro Histórico
€52
14 Oct - 15 Oct
Gran Hotel Santa Cruz
View all properties

Top Santa Cruz Hotel Reviews

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 7 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Blacutt Square, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are two other upscale options for your trip.
How many luxury hotels are there in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 7 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Blacutt Square and Ramon Tahuichi Aguilera Stadium. If you have a little extra time during your trip, you might want to make a stop at Santa Cruz Zoo and Ventura Mall.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To venture out into the surrounding area, hop aboard a train at Santa Cruz de la Sierra Station.