A colonial-style building with a bell tower, palm trees, and a paved walkway.

Santa Cruz Hotel Guide - Luxury Hotels in Santa Cruz, Santa Cruz

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Check availability on Santa Cruz Luxury Hotels

Tonight
29 Aug - 30 Aug
Tomorrow
30 Aug - 31 Aug
Next weekend
4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

Our top choices for Santa Cruz luxury hotels

A high-rise hotel room with a large bathtub, two massage tables, and a city view.
A spacious room with a wooden floor and large windows offering a city view.
A modern restaurant with large windows, a central dining area with tables and chairs, and a view of the outdoors.
A rooftop pool with a city view, a red lounge chair, and a potted plant.

1. Swissôtel Santa Cruz De La Sierra

Swissôtel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in spa treatments, outdoor pool relaxation, and friendly concierge service at this entertainment district luxury retreat.
€141
12 Sept - 13 Sept
Swissôtel Santa Cruz De La Sierra
A spacious lobby with high ceilings, modern furniture, and large windows allowing natural light.
A hot tub with a wooden deck and stone walls, surrounded by a pool.
A large, illuminated swimming pool surrounded by palm trees and pathways.
A spacious lobby with high ceilings, large windows, and a modern chandelier.

2. Camino Real Hotel

Camino Real Hotel
Santa Cruz
  • Waterside luxury retreat with full-service spa offers poolside cocktails, garden-view dining, and indoor-outdoor swimming pools.
€124
14 Sept - 15 Sept
Camino Real Hotel
A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.
A modern lobby with a dining area, sofas, and a decorative wall.
A luxurious banquet hall with ornate chandeliers, floral arrangements, and elegant table settings.
A restaurant with a high ceiling, large windows, and a view of the cityscape. Tables are set with plates, glasses, and cutlery.

3. Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel
Santa Cruz
  • Luxury escape in Santa Cruz's business district offers full-service spa treatments, outdoor pool relaxation, and upscale dining.
€91
4 Sept - 5 Sept
Marriott Santa Cruz de la Sierra Hotel
A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.
A hotel with a prominent 'Hampton' sign, large windows, and a modern facade.
A modern hotel lobby with a bar area, seating arrangements, and a television.
A small, enclosed garden area with various potted plants and a gravel path.

4. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Santa Cruz
  • Indulge in luxury and convenience at this 4.5-star Bolivia hotel offering fine dining, fitness amenities, and garden views.
€65
31 Aug - 1 Sept
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
A spacious hotel lobby with modern furnishings, large windows offering city views, and unique hanging light fixtures.
A modern hotel pool area with a hot tub, lounge chairs, and a covered seating area.
A spacious lobby with a high ceiling, modern furniture, and a central seating area.

5. Novotel Santa Cruz De La Sierra

Novotel Santa Cruz De La Sierra
Santa Cruz
  • Indulge in art deco elegance at this Santa Cruz hotel with luxurious pools and concierge service.
€111
2 Sept - 3 Sept
Novotel Santa Cruz De La Sierra
A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.
A modern lounge area with leather sofas, a coffee table, and a view of a green wall with plants.
A reception area with a marble counter, a large chandelier, and a digital display.
A rooftop pool area with a view of the city skyline at dusk.

6. TRYP by Wyndham Santa Cruz

TRYP by Wyndham Santa Cruz
Santa Cruz
€84
30 Aug - 31 Aug
TRYP by Wyndham Santa Cruz
View all properties

Top Santa Cruz Hotel Reviews

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

10/10 Excellent
"Las piscinas son buenazas, la comida también, súper bien ubicado. Pero hay una zona que no tiene ascensor si te toca cuarto ahí y tienes silla de ruedas avisar"
DANIELA 2-night trip
Posted 1 day ago
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Frequently asked questions

Are you looking for a luxury hotel for your Santa Cruz holiday?
Travel to Santa Cruz (SRZ-El Trompillo) Airport or Santa Cruz (VVI-Viru Viru Intl.) Airport, and then treat yourself to a stay at one of 6 Santa Cruz luxury hotels. Santa Cruz has some interesting things to see and do including Plaza 24 de Septiembre and Cine Center, so you might want to take in the local sights during your visit.
What's the best high-end hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travellers looking for an elegant place to stay. Camino Real Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia are two other upscale options for your trip.
How many luxury hotels are there in Santa Cruz?
Lie in the lap of luxury during your getaway to Santa Cruz in one of Expedia's 6 luxury hotels.
When can I expect good weather in Santa Cruz?
Planning for the weather is a good way to make your trip to Santa Cruz relaxing and enjoyable, especially when you're splurging. The hottest months are usually October and November, with an average temperature of 26°C, while the coldest months are June and July, with an average of 21°C. Average annual precipitation for Santa Cruz is 1208 mm.
What's there to see and do in Santa Cruz?
Enjoy all that Santa Cruz has to offer when you visit Plaza 24 de Septiembre, Cine Center and Santa Cruz Zoo. If you have a little extra time during your trip, you might want to make a stop at Ventura Mall and Guembe Biocenter.
How can I get around Santa Cruz?
It's easier to get around town comfortably when you know your options. To venture out into the surrounding area, hop aboard a train at Santa Cruz de la Sierra Station.