Santa Cruz Hotels

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santa Cruz hotels

Little Italy B&B

Little Italy B&B
3.0 star property
Tijeras
9.4 out of 10, Exceptional, (52 reviews)
"We had a great time at Little Italy bed and breakfast, the room was large and clean, the beds were comfortable, and there was plenty of room to move around. It was close to the bus stop and it was a very nice and safe area. We enjoyed walking around the block. And the breakfast was always fresh and delicious!"
Canada
Karine
The price is €38
includes taxes & fees
29 Apr - 30 Apr
Little Italy B&B

Linda Vista Cabins

Linda Vista Cabins
3.0 star property
Alto Boquete
9.2 out of 10, Wonderful, (18 reviews)
"Property was the best local accommodation I have had in Panama. The host was outstanding. "
United States
Don
The price is €46
includes taxes & fees
4 May - 5 May
Linda Vista Cabins

Los Brezos Boutique Hotel

Los Brezos Boutique Hotel
3.5 star property
Volcan
9.4 out of 10, Exceptional, (30 reviews)
"Los Brezos is the best hotel in the area. The restaurant is amazing, the food at all times is delicious and high standard"
United States
Damaris
The price is €111
includes taxes & fees
29 Apr - 30 Apr
Los Brezos Boutique Hotel

Los Quetzales Ecolodge & Spa

Los Quetzales Ecolodge & Spa
3.0 star property
Cerro Punta
8.8 out of 10, Excellent, (36 reviews)
"Staff were friendly and helpful. Room was okay."
Australia
Michael
The price is €101
includes taxes & fees
29 Apr - 30 Apr
Los Quetzales Ecolodge & Spa

Hotel Las Canarias

Hotel Las Canarias
3.0 star property
Paso Canoas
The price is €43
includes taxes & fees
29 Apr - 30 Apr
Hotel Las Canarias

Hotel Dos Rios

Hotel Dos Rios
3.0 star property
Nueva California
8.6 out of 10, Excellent, (82 reviews)
"Beautiful garden "
Canada
Kevin
The price is €80
includes taxes & fees
3 May - 4 May
Hotel Dos Rios

Casa Little Italy

Casa Little Italy
3.0 star property
Tijeras
6.0 out of 10, (1 review)
"Didn't accept credit card payment "
Mexico
ANGELO
The price is €65
includes taxes & fees
29 Apr - 30 Apr
Casa Little Italy

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals
3.0 star property
Volcan
8.2 out of 10, Very good, (256 reviews)
"nice classy place. with beautiful grounds.."
Canada
Gordon J
The price is €104
includes taxes & fees
28 May - 29 May
Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals

Luxury Canyon Suites

Luxury Canyon Suites
2.0 star property
Alto Boquete
7.0 out of 10, Good, (6 reviews)
"New place, still developing "
United States
Amanda
The price is €79
includes taxes & fees
3 May - 4 May
Luxury Canyon Suites

Hotel Finca Lerida

Hotel Finca Lerida
3.0 star property
Los Naranjos
8.8 out of 10, Excellent, (198 reviews)
"Great place"
United States
Roberto
The price is €163
includes taxes & fees
3 May - 4 May
Hotel Finca Lerida

Hostal Victoria Volcán Chiriquí S. A.

Hostal Victoria Volcán Chiriquí S. A.
2.0 star property
Nueva California
9.0 out of 10, Wonderful, (10 reviews)
"Hostal Victoria was a simple and down-to-earth Hostal. The entire staff were friendly, kind, and helpful. Good value for a budget place to stay. "
United States
John
The price is €42
includes taxes & fees
29 Apr - 30 Apr
Hostal Victoria Volcán Chiriquí S. A.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

Frequently asked questions

Where is the best place to stay in Santa Cruz?
Located 12.3 mi (19.8 km) from the heart of Santa Cruz, Hotel Faranda Bambito Chiriquí, a member of Radisson Individuals is a top choice for your stay, based on our traveller data. Other good options for your visit to the area are Hotel Dos Rios and Los Quetzales Ecolodge & Spa. See all available top hotels, or vacation rentals in Santa Cruz.
What are some of the best holiday rentals that Santa Cruz has to offer?
King bed & hot tub in cloud forest mountains: This holiday home rental outside of Santa Cruz is located on a river, and has a garden, 1 hot tub and laundry facilities to put you at ease in your new surroundings. It has 4 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as table football. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! The majority of room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a non-refundable reservation, it may still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
What's it like to stay in Santa Cruz?
Visitors to Santa Cruz will definitely find plenty to explore and enjoy. There are 54 hotels and other accommodation options in the surrounding area. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Places to visit in the wider area include Las Cavernas de Corredores, Barriles and Sitio Barriles Museum. You'll also find Paradise Tropical Garden and Canyon Macho de Monte in the area. Take a look at what more there is to see and do in Expedia's Santa Cruz guide.
What's the seasonal weather in Santa Cruz?
The hottest months are usually March and February, with an average temperature of 26°C, while the coldest months are January and December, with an average of 25°C. The rainiest months in Santa Cruz are October, November, August and July, with each month seeing an average of 752 mm of rainfall.