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21C Museum Hotel St Louis

4.5 star property
Contemporary art meets comfort at this downtown St. Louis hotel where travelers can unwind after exploring nearby Busch Stadium and other iconic attractions

Choose dates to view prices

21C Museum Hotel St Louis stands in the heart of the city, offering travelers a refined experience with its indoor pool and fitness center. Guests can book a massage at the spa, play billiards at the bar, or start their day with a cooked-to-order breakfast at the coffee shop.

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Pet-friendly
  • Free Wi-Fi
  • Air-conditioning
The current price is €155
includes taxes & fees
5 Apr - 6 Apr

Room options

Available filters for rooms
Showing 10 of 10 rooms

View all photos for Deluxe Room, 1 King Bed

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, 1 King Bed

9.0 out of 10
Wonderful
(92 reviews)
  • 29 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

Luxury Double Room, 2 Queen Beds

9.4 out of 10
Exceptional
(29 reviews)
  • 39 sq m
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Room (Bunk Bed)

Room (Bunk Bed)

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 22 sq m
  • Sleeps 2
  • 1 Single Bunk Bed

View all photos for Loft, 2 Queen Beds

Loft, 2 Queen Beds

Loft, 2 Queen Beds

8.0 out of 10
Very good
(1 review)
  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, Accessible (Accessible)

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Room, Accessible (Accessible)

  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

Suite, 1 King Bed (Library)

  • City view
  • 68 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

Luxury Suite, 1 King Bed

10.0 out of 10
Exceptional
(1 review)
  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

In-room safe, desk, laptop workspace, blackout curtains

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

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About the area

Located in St. Louis, 21C Museum Hotel St Louis is in the city centre. St. Louis Union Station and Gateway Arch are notable landmarks, and the area's natural beauty can be seen at Mississippi River and Forest Park. Check out an event or a game at Enterprise Center, and consider making time for St. Louis Zoo, a top attraction not to be missed. Visit our St. Louis travel guide
Map
1528 Locust street, St. Louis, MO, 63103

What's nearby

  • Washington Avenue Historic District
    Washington Avenue Historic District
    2 min walk - 0.2 km
  • City Museum as well as a small group of people
    City Museum
    5 min walk - 0.4 km
  • Union Station, St. Louis, MO
    St. Louis Union Station
    8 min walk - 0.7 km
  • Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.
    Enterprise Center
    8 min walk - 0.7 km
  • St. Louis Aquarium at Union Station
    11 min walk - 1.0 km

Getting around

  • 8th and Pine Station
    13 min walk
  • St. Louis Gateway Station
    14 min walk
  • Lambert-St. Louis International Airport (STL)
    24 min drive

Restaurants

  • Imo's Pizza Headquarters & Retail Store
    7 min walk
  • Budweiser Kiel Club
    6 min walk
  • Rosalita's Cantina
    6 min walk
  • White Knight Diner
    4 min walk
  • Blood & Sand
    2 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel near Enterprise Center
Located close to St. Louis Union Station and Busch Stadium, 21C Museum Hotel St Louis provides a coffee shop/cafe, dry cleaning/laundry services and a bar. Treat yourself to a massage or other spa services. In addition to a gym and a business centre, guests can connect to free in-room WiFi.
You'll also enjoy the following perks during your stay:
  • An indoor pool
  • Cooked-to-order breakfast (surcharge), valet parking (surcharge) and a lift
  • A vending machine, concierge services and a banquet hall
  • ATM/banking services, a 24-hour front desk and meeting rooms
  • Guest reviews say great things about the dining options, pool and helpful staff
Room features
All 104 rooms include comforts such as laptop-friendly workspaces and air conditioning, as well as perks such as free WiFi and desk chairs. Guest reviews highly rate the cleanliness rooms at the property.
More amenities include:
  • Free toiletries and hairdryers
  • Flat-screen TVs with premium channels
  • Wardrobes/cupboards, heating and daily housekeeping

Awards and affiliations

Eco-certified property
This property participates in Green Key Global – a program that measures the property's impact on one or more of the following: environment, community, cultural-heritage, the local economy.

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Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)
  • Limited on-site valet parking

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age - 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property
Information provided by the property may be translated using automated translation tools

Access methods

Staffed front desk

Pets

Pets are allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available.
Cots (infant beds) are not available

Payment types at the property

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

This property is managed by a professional host. The provision of housing is linked to their trade, business or profession.
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a fire extinguisher, a smoke detector and outdoor lighting
If you cancel your booking, you'll be subject to the host's cancellation policy. In accordance with EU regulations about consumer rights, property booking services are not subject to the right of withdrawal.

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

Frequently asked questions

Does 21C Museum Hotel St Louis have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at 21C Museum Hotel St Louis ?

As of 26 Mar 2026, prices found for a 1-night stay for 2 adults at 21C Museum Hotel St Louis on 5 Apr 2026 start from €155, including taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is 21C Museum Hotel St Louis pet-friendly?

Yes, dogs are allowed at this property. There's a fee of USD 100 per accommodation, per stay. Service animals are exempt from fees.

How much is parking at 21C Museum Hotel St Louis ?

Valet parking is available for USD 50 per day.

What time is check-in at 21C Museum Hotel St Louis ?

Check-in start time: 4:00 PM; check-in end time: 11:00 AM. Late check-in is available during limited hours.

What time is check-out at 21C Museum Hotel St Louis ?

Checkout is at 11:00 AM.

Where is 21C Museum Hotel St Louis located?

Located in Downtown West, this luxury hotel is within a 10-minute walk of Campbell House Museum, Enterprise Center, and St. Louis Union Station. City Museum and America's Center Convention Complex are also within 15 minutes. 8th and Pine Station is 13 minutes by foot and Convention Center Station is 15 minutes.

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Reviews

21C Museum Hotel St Louis Reviews

9.0

Wonderful

9.2

Cleanliness

9.2

Amenities

9.0

Staff & service

9.4

Property conditions & facilities
Rating 10 - Excellent. 1202 out of 1689 reviews
Rating 8 - Good. 260 out of 1689 reviews
Rating 6 - Okay. 116 out of 1689 reviews
Rating 4 - Poor. 51 out of 1689 reviews
Rating 2 - Terrible. 60 out of 1689 reviews

Reviews

Verified

10/10 Excellent

Amanda

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Absolutely beautiful, amazing breakfast, comfy bed!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Chad

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
A fantastic stay. Great breakfast and excellent pool area. Would stay again
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Mike

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Beautiful place, friendly staff! Enjoyed our stay and will definitely come back!!!
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Kelly

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a great stay at the Museum hotel! Place was gorgeous, room very clean & the staff was wonderful! Highly recommend!
Stayed 3 nights in Mar 2026
Verified

10/10 Excellent

Robert

Liked: Cleanliness, amenities, property conditions & facilities
Great service. Would definitely stay again
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

steven h

Liked: Cleanliness, staff & service, property conditions & facilities
Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

ashley

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Amazing hotel to stay in. Customer service like none other - art museum amazing. Don’t wait to take a look around. Food delicious! Gym has everything you want!
Stayed 4 nights in Mar 2026
Verified

10/10 Excellent

Marjorie D

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
great staff, very clean-but surprised that there was no art in the hall ways or rooms. everything was really good. its a beautiful space, do not skip the gallery museum, or the bar cocktails
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Christopher

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great service and vibe. The art exhibit on the second floor is worth the time and free!
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Elizabeth

Liked: Cleanliness, amenities, property conditions & facilities
Beautiful space. Clean room. Friendly staff.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Dimitre

Liked: Cleanliness, amenities, property conditions & facilities
Great hotel! Art, food and drinks were fantastic
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

Sarah

Liked: Cleanliness, amenities, property conditions & facilities
Pleasant staff
Stayed 3 nights in Feb 2026
Verified

8/10 Good

Corie Elizabeth

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Staff was very friendly and helpful. Loved receiving the tour of the current art show! A must in my opinion. Loved Idol Wolf and Good Press for breakfast or happy hour. Wish they offered more than massage services in the spa though. If you prefer getting around town on foot or public transportation, I probably wouldn’t choose this location.
Stayed 3 nights in Mar 2026
Verified

10/10 Excellent

Diana

Liked: Cleanliness, property conditions & facilities
Room was clean stuff was friendly and everyone was super nice
Stayed 2 nights in Feb 2026
Verified

10/10 Excellent

Juanita

Liked: Cleanliness, amenities, property conditions & facilities
The rooms were nice and clean. Staff was friendly.
Stayed 1 night in Jan 2026
Verified

6/10 Okay

Ebony

Liked: Staff & service
Disliked: Amenities, property conditions & facilities
The staff was good but the room looked like the bathroom needed to be mopped no amenities like normal hotels and the ceiling looked like it was patched together and was about to fall in
Stayed 1 night in Mar 2026
Verified

8/10 Good

Mikel

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great Location, great atmosphere. Drinks and food on the floor level, beautiful artwork is on display.
Stayed 1 night in Jan 2026
Verified

10/10 Excellent

shelby

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
it was very pretty inside, its was very clean overall but there was some loose hairs around the room lol. It was close to downtown, food, fun attractions like the union station! this was my first time to st.louis and i will definitely be back and staying at the 21c hotel! Also forgot to mention when we checked in we were given a free shot of bourbon at bar which was nice! Bar staff was also so kind to us.
Stayed 1 night in Mar 2026
Verified

8/10 Good

Allison

Liked: Staff & service, amenities, property conditions & facilities
The staff were excellent and very friendly, however the bedding in our room had stains on the pillow cases and looked like they hadn’t been changed. I feel the room could’ve been cleaned better.
Stayed 1 night in Mar 2026
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Cool hotel to stay at near enterprise center. Had fun with the penguins and liked the activities in the hotel (museum, pool table, shuffleboard)
Stayed 1 night in Jan 2026
Verified

8/10 Good

Cody

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room was quite smile even for 1. Hot water took awhile to heat up. No ice maker on floor. Great location for enterprise center.
Stayed 1 night in Feb 2026
Verified

10/10 Excellent

Meredith

Liked: Cleanliness, amenities, property conditions & facilities
Hotel was very quiet and staff helpful and courteous. The coffee shop was great for coffee and breakfast and the rooms were clean with hot water and great water pressure. The only thing I would change was the mattress - bed was very firm, kind of felt like lying on a table. Gallery was a fun feature and next time I'm in STL I will be back!
Stayed 1 night in Jan 2026
Verified

8/10 Good

Nicole

Liked: Staff & service, amenities, property conditions & facilities
Staff was great. Lobby area was great. As far as my room there could have been some improvements. Looking at it briefly it’s looked nice however after actually staying in it there were def some issues. The shower door didn’t close all the way. There was lots of stains throughout the room on the rug, curtains, and the wall as if something splattered in numerous spots.
Stayed 2 nights in Mar 2026
Verified

10/10 Excellent

Jennifer

Liked: Cleanliness, staff & service, amenities
Clean room, nice linens, great view!
Stayed 1 night in Dec 2025
Verified

10/10 Excellent

Sharon

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was comfortable, clean and unique. All staff was wonderful
Stayed 3 nights in Dec 2025