American Airlines Cheap Flights from Panama City to Key West

Scoring cheap one-way American Airlines flights from ECP to EYW on Expedia is simple — just filter by "Price (lowest to highest)." Or check out our budget-friendly round-trip fares for your next break.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

Look for round-trip or one-way flights to Key West in September or August. You could find an affordable fare with American Airlines during these off-season months.

To find out if there's a direct trip from ECP to EYW with American Airlines or another carrier, select the "Nonstop" filter when looking for tickets.

Key West Intl. Airport (EYW) is the main Key West gateway for American Airlines flights from Northwest Florida Beaches Intl. Airport (ECP).

In most cases, you can cancel or modify your flight, although additional fees may apply if your booking was made over 24 hours ago. Need to keep your options open? Make use of our "Changes included" and "No cancel fee" filters to find flights that won't charge you extra if you need to revise your plans. To update your itinerary, go to "Trips," select your flight and click on "Manage Booking" for more details.