An abandoned, dilapidated wooden house surrounded by overgrown vegetation and leafless trees.

4 Star Hotels in Central United States, United States of America

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Central United States 4 Star Hotels

Next weekend
In two weeks

Our top choices for Central United States 4-star hotels

Hilton Chicago O'Hare Airport

Hilton Chicago O'Hare Airport
4.0 star property
O'Hare
8.4 out of 10, Very good, (2,320 reviews)
"The staff was excellent and you can’t beat the proximity to the airport."
United States
Hannah
The price is €263
includes taxes & fees
3 Jul - 4 Jul
Hilton Chicago O'Hare Airport

Gaylord Opryland Resort & Convention Center

Gaylord Opryland Resort & Convention Center
4.0 star property
Opryland
8.8 out of 10, Excellent, (1,776 reviews)
"So beautiful and has so much to do right there at the resort!"
United States
Pamela
The price is €370
includes taxes & fees
12 Jul - 13 Jul
Gaylord Opryland Resort & Convention Center

Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,002 reviews)
"Great place to stay"
United States
Gayathry
The price is €279
includes taxes & fees
6 Jul - 7 Jul
Hotel Zaza Houston Museum District

Moody Gardens Hotel, Spa and Convention Center

Moody Gardens Hotel, Spa and Convention Center
4.0 star property
Near West End
9.0 out of 10, Wonderful, (2,115 reviews)
"Excellent resort hotel - highly recommended!"
United States
Richard
The price is €189
includes taxes & fees
5 Jul - 6 Jul
Moody Gardens Hotel, Spa and Convention Center

Hyatt Regency O'Hare Chicago

Hyatt Regency O'Hare Chicago
4.0 star property
Rosemont
8.8 out of 10, Excellent, (2,736 reviews)
"Hotel was clean, very friendly staff and conveniently located from the airport"
United States
Jason
The price is €127
includes taxes & fees
1 Jul - 2 Jul
Hyatt Regency O'Hare Chicago

InterContinental New Orleans by IHG

InterContinental New Orleans by IHG
4.0 star property
New Orleans Central Business District
9.0 out of 10, Wonderful, (2,101 reviews)
"Awesome stay."
United States
Michael
The price is €99
includes taxes & fees
6 Jul - 7 Jul
InterContinental New Orleans by IHG

Margaritaville Beach Resort South Padre Island

Margaritaville Beach Resort South Padre Island
4.0 star property
South Padre Island
8.6 out of 10, Excellent, (2,327 reviews)
"Clean room, great staff and nice restaurants"
United States
Perry
The price is €223
includes taxes & fees
19 Jul - 20 Jul
Margaritaville Beach Resort South Padre Island

Hilton Cincinnati Netherland Plaza

Hilton Cincinnati Netherland Plaza
4.0 star property
Downtown Cincinnati
8.0 out of 10, Very good, (1,574 reviews)
"Great historical property close to many restaurants and sites."
United States
Katharine
The price is €134
includes taxes & fees
5 Jul - 6 Jul
Hilton Cincinnati Netherland Plaza

The Chicago Hotel Collection Ambassador Gold Coast

The Chicago Hotel Collection Ambassador Gold Coast
4.0 star property
Downtown Chicago
8.2 out of 10, Very good, (1,650 reviews)
"Very good location, breakfast is fantastic, dinner and bar are great."
United States
Zhiwen
The price is €120
includes taxes & fees
1 Jul - 2 Jul
The Chicago Hotel Collection Ambassador Gold Coast

Palmer House a Hilton Hotel

Palmer House a Hilton Hotel
4.0 star property
Downtown Chicago
8.6 out of 10, Excellent, (2,499 reviews)
"Beautiful place to stay."
United States
Charles Otto
The price is €260
includes taxes & fees
2 Jul - 3 Jul
Palmer House a Hilton Hotel

Omni Chicago Hotel

Omni Chicago Hotel
4.5 star property
Downtown Chicago
9.2 out of 10, Wonderful, (1,830 reviews)
"All around great property and a wonderful location"
United States
Bruce
The price is €189
includes taxes & fees
5 Jul - 6 Jul
Omni Chicago Hotel

InterContinental Chicago Magnificent Mile by IHG

InterContinental Chicago Magnificent Mile by IHG
4.5 star property
Downtown Chicago
9.2 out of 10, Wonderful, (3,116 reviews)
"Clean and spacious room, staff was great. Great location easy to walk to other activities and restaurants."
United States
Sabrina
The price is €256
includes taxes & fees
6 Jul - 7 Jul
InterContinental Chicago Magnificent Mile by IHG

Loews Arlington

Loews Arlington
4.5 star property
East Arlington
9.6 out of 10, Exceptional, (2,260 reviews)
"Great place to stay We had a great experience the location is perfect for our weekend getaway."
United States
Martin
The price is €227
includes taxes & fees
17 Jul - 18 Jul
Loews Arlington

THE MIDLAND HOTEL, Chicago, a Tribute Portfolio Hotel

THE MIDLAND HOTEL, Chicago, a Tribute Portfolio Hotel
4.0 star property
Downtown Chicago
8.4 out of 10, Very good, (1,007 reviews)
"Great stay!"
United States
Alondra
The price is €158
includes taxes & fees
5 Jul - 6 Jul
THE MIDLAND HOTEL, Chicago, a Tribute Portfolio Hotel

Hyatt Regency Chicago

Hyatt Regency Chicago
4.0 star property
Downtown Chicago
9.4 out of 10, Exceptional, (3,443 reviews)
"Staff was great."
United States
Marianne
The price is €284
includes taxes & fees
1 Jul - 2 Jul
Hyatt Regency Chicago

Magnolia Hotel Dallas Downtown

Magnolia Hotel Dallas Downtown
4.0 star property
Downtown Dallas
8.0 out of 10, Very good, (3,987 reviews)
"Very nice stay will come back again"
United States
Jimmy
The price is €109
includes taxes & fees
19 Jul - 20 Jul
Magnolia Hotel Dallas Downtown

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (4,280 reviews)
"Great stay, close to Daikin park!"
United States
Anthony
The price is €100
includes taxes & fees
6 Jul - 7 Jul
Club Quarters Hotel Downtown, Houston

Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk
4.0 star property
Downtown San Antonio
9.4 out of 10, Exceptional, (4,810 reviews)
"Beautiful hotel excellent location"
United States
Melisa
The price is €156
includes taxes & fees
6 Jul - 7 Jul
Drury Plaza Hotel San Antonio Riverwalk

The San Luis Resort, Spa & Conference Center

The San Luis Resort, Spa & Conference Center
4.0 star property
Midtown
9.0 out of 10, Wonderful, (1,344 reviews)
"Always a great stay!!"
United States
Sandra
The price is €358
includes taxes & fees
1 Jul - 2 Jul
The San Luis Resort, Spa & Conference Center

Grand Galvez Resort, Autograph Collection

Grand Galvez Resort, Autograph Collection
4.0 star property
San Jacinto
9.0 out of 10, Wonderful, (1,244 reviews)
"We had an amazing stay."
United States
Rose
The price is €208
includes taxes & fees
27 Jul - 28 Jul
Grand Galvez Resort, Autograph Collection
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Central United States.
Still don't see what you're looking for?
See all properties in Central United States.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Central United States

Enjoy access to sights and activities in the surrounding area during your stay in Central United States.

The Gateway Arch in St. Louis, Missouri, with a clear blue sky and surrounding buildings.
Photo by Michael Schuier
Open Photo by Michael Schuier

Top Central United States Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Central United States?
According to Expedia customer reviews, Casablanca Hotel by Library Hotel Collection is among the standout 4-star hotels in Central United States. Located in New York, it comes with premium bedding and concierge services. Hilton New York Times Square is another popular choice in this city. Also rated 4 stars and offering premium bedding and designer toiletries, it promises an enjoyable stay.
How much does it cost to stay in a 4-star hotel in Central United States?
To lock in a 4-star hotel in Central United States that matches your budget, use Expedia's filter tool. Browse the available options during your chosen dates and use our pricing filter to set your maximum rate. You can also list your results by the most affordable escape first.

  • Search for the lowest price from €191

What's the difference between 5-star and 4-star hotels in Central United States?
Offering an inviting guest experience and upscale surroundings, 4-star hotels are a terrific option for your Central United States holiday. These types of accommodation generally come with lots of useful amenities that make it easy to unpack and unwind — think complimentary bathrobes, gyms and restaurants. Or get a taste of the high life at a 5-star hotel designed to indulge you in high-end perks and amenities. 24-hour front desk, oversized bathrooms and gourmet dining are typically included at these plush properties.