4 Star Hotels in Southeastern Indiana, United States of America

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Southeastern Indiana 4 Star Hotels

This weekend
Next weekend

Our top choices for Southeastern Indiana 4-star hotels

Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (4,086 reviews)
"Rooms were clean and staff were friendly! "
United States
Amy
The price is €126
includes taxes & fees
30 Mar - 31 Mar
Galt House Hotel Trademark Collection by Wyndham

Omni Louisville Hotel

Omni Louisville Hotel
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,782 reviews)
"Amazing stay! "
United States
Erin
The price is €183
includes taxes & fees
29 Mar - 30 Mar
Omni Louisville Hotel

Embassy Suites Louisville Downtown

Embassy Suites Louisville Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,158 reviews)
"Great room and breakfast. Close to several nice restaurants."
United States
Crystal
The price is €114
includes taxes & fees
8 Mar - 9 Mar
Embassy Suites Louisville Downtown

The Brown Hotel

The Brown Hotel
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,186 reviews)
"Beautiful old hotel with a fantastic bar in the lobby"
United States
Karen
The Brown Hotel

Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (1,046 reviews)
"Spotless room and courteous staff "
United States
Mary
The price is €134
includes taxes & fees
8 Mar - 9 Mar
Hotel Genevieve part of JdV by Hyatt

21c Museum Hotel Louisville

21c Museum Hotel Louisville
4.5 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,004 reviews)
"Great room, super kind staff"
United States
Rachel
The price is €183
includes taxes & fees
22 Mar - 23 Mar
21c Museum Hotel Louisville

Hyatt Regency Louisville

Hyatt Regency Louisville
4.0 star property
Downtown Louisville
8.8 out of 10, Excellent, (1,002 reviews)
"Everything was just excellent on the day I stayed."
United States
Peggy
The price is €143
includes taxes & fees
30 Mar - 31 Mar
Hyatt Regency Louisville

The Grady

The Grady
4.0 star property
Downtown Louisville
9.4 out of 10, Exceptional, (1,001 reviews)
"Such an amazing hotel...restaurant is delicious! "
United States
Craig
The price is €322
includes taxes & fees
26 Mar - 27 Mar
The Grady

Louisville Marriott Downtown

Louisville Marriott Downtown
4.0 star property
Downtown Louisville
9.0 out of 10, Wonderful, (1,002 reviews)
"Very nice hotel. Great stay!"
United States
Brad
The price is €179
includes taxes & fees
21 Mar - 22 Mar
Louisville Marriott Downtown

Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
4.0 star property
Downtown Louisville
9.6 out of 10, Exceptional, (451 reviews)
"Great hotel & location"
United States
Ana
The price is €174
includes taxes & fees
29 Mar - 30 Mar
Hotel Distil, Autograph Collection

Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
4.0 star property
Downtown Louisville
9.2 out of 10, Wonderful, (77 reviews)
"i love this place"
United States
THANH
The price is €171
includes taxes & fees
29 Mar - 30 Mar
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
4.0 star property
Downtown Louisville
8.6 out of 10, Excellent, (1,003 reviews)
"The area was congested but the motel was good. "
United States
Byrd
The price is €148
includes taxes & fees
15 Mar - 16 Mar
Seelbach Hilton Louisville Downtown

Stellar Suites

Stellar Suites
4.5 star property
Downtown Louisville
9.6 out of 10, Exceptional, (123 reviews)
"The check-in process was simple and easy, the room was spotless and had so many amenities. "
United States
Grace
The price is €160
includes taxes & fees
16 Mar - 17 Mar
Stellar Suites

The Pepin Mansion Historic B&B

The Pepin Mansion Historic B&B
4.0 star property
New Albany
9.8 out of 10, Exceptional, (668 reviews)
"The room was fantastic. Great location. Breakfast was excellent!! Mimi, the innkeeper, was gracious and very helpful with restaurant recommendations. Truly enjoyed my stay. "
United States
Kimberly
The price is €81
includes taxes & fees
3 Mar - 4 Mar
The Pepin Mansion Historic B&B

CozySuites at Nulu

CozySuites at Nulu
4.0 star property
Downtown Louisville
8.0 out of 10, Very good, (27 reviews)
"Wonderful stay - great spot and lots of great dining options and bars nearby "
United States
Roy
The price is €166
includes taxes & fees
9 Mar - 10 Mar
CozySuites at Nulu

stayAPT Suites Louisville North-Clarksville

stayAPT Suites Louisville North-Clarksville
4.0 star property
Clarksville
9.8 out of 10, Exceptional, (46 reviews)
"room very good i love hotel ❤️"
United States
Kartar
stayAPT Suites Louisville North-Clarksville

The Reserve on Main

The Reserve on Main
4.0 star property
Downtown Louisville
10.0 out of 10, Exceptional, (1 review)
"Incredible stay. This stay was clean and inspiring for anyone wishing to take a break and recharge. We highly recommend this stay to everyone staying in the city. "
Canada
georgios
The price is €204
includes taxes & fees
4 Mar - 5 Mar
The Reserve on Main

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb
4.0 star property
Sellersburg
9.4 out of 10, Exceptional, (10 reviews)
"Very nice house in a nice neighborhood, spacious home environmental, felt more that at home there,"
United States
Tammy
Spacious 3 BR Ranch House W Patio Yard in a Quiet Suburb

TWO Stunning Nulu CozySuites

TWO Stunning Nulu CozySuites
4.0 star property
Downtown Louisville
TWO Stunning Nulu CozySuites

Hawthorn Suites by Wyndham Louisville North

Hawthorn Suites by Wyndham Louisville North
4.5 star property
Jeffersonville
7.4 out of 10, Good, (944 reviews)
"I would say that the hotel is in pretty good shape. The rooms are very nice. The parking lot however had a ton of people just hanging out. It made it a bit uncomfortable"
United States
alexis
Hawthorn Suites by Wyndham Louisville North
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Southeastern Indiana

Explore lots to see and do in Southeastern Indiana—live music, sports teams and sights from Deam Lake State Recreation Area to Huber’s Orchard, Winery & Vineyards.

Belle of Louisville featuring a bay or harbour and a ferry as well as a small group of people

Top Southeastern Indiana Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Southeastern Indiana?
You'll find an array of 4-star hotels in Southeastern Indiana, including in Louisville. Galt House Hotel Trademark Collection by Wyndham is a guest favourite in this city that offers concierge services and massage services. Another property that gets excellent reviews from travellers is Hyatt Regency Louisville. A swimming pool and concierge services help make it a top choice.
How much does it cost to stay in a 4-star hotel in Southeastern Indiana?
Expedia can help you easily track down the ideal 4-star hotel for your holiday in Southeastern Indiana. Use our filter tool to fine-tune your search by things like price, amenities and hotel star rating and get access to fantastic deals in a few clicks.

  • Search for the lowest price from €81

What's the difference between 5-star and 4-star hotels in Southeastern Indiana?
If you decide to book a stay at a 4-star hotel in Southeastern Indiana, you'll usually find plenty of conveniences to make sure you're relaxed, such as a gym, restaurant and pool. You can look forward to excellent service and upmarket surroundings. Choose a 5-star hotel and you'll have access to a few more perks — think on-site spas, around-the-clock concierge and indulgent turndown services. You're likely to get additional amenities and first-rate services at a 5-star stay, but both are terrific options for luxury guests.