5 Star Hotels in Florida Keys, United States of America
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Check availability on Florida Keys 5 Star Hotels
Top Florida Keys 5 Star Hotels

Cheeca Lodge & Spa
Cheeca Lodge & Spa
9.0 out of 10, Wonderful, (1149)
The price is €210
includes taxes & fees
19 Aug - 20 Aug

Isla Bella Beach Resort & Spa
Isla Bella Beach Resort & Spa
9.2 out of 10, Wonderful, (1020)
The price is €260
includes taxes & fees
14 Sept - 15 Sept
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.

Hawks Cay Resort
61 Hawks Cay Blvd, Marathon, FL
The price is €251 per night from 26 Aug to 27 Aug
€251
26 Aug - 27 Aug
includes taxes & fees
8/10 Very Good! (1,009 reviews)
Still don't see what you're looking for?
See all properties in Florida Keys.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Florida Keys
Snorkel crystal-clear waters teeming with colourful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

Top Florida Keys Hotel Reviews

Cheeca Lodge & Spa
10/10 Excellent

Isla Bella Beach Resort & Spa
10/10 Excellent
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Near an Attraction
- Hotels near Duval Street
- Hotels near Mallory Square
- Hotels near Smathers Beach
- Hotels near Sombrero Beach
- Hotels near Ernest Hemingway Home and Museum
- Hotels near Biscayne National Park
- Hotels near Key West Golf Club
- Hotels near Clarence S. Higgs Memorial Beach Park
- Hotels near Seven Mile Bridge
- Hotels near Key West Butterfly and Nature Conservatory
Hotel Theme
- Adventure Sport Hotels in Florida Keys
- All Inclusive Hotels in Florida Keys
- Beach Hotels in Florida Keys
- Boutique Hotels in Florida Keys
- Business Hotels in Florida Keys
- Casino Hotels in Florida Keys
- Cheap Hotels in Florida Keys
- Family Friendly Hotels in Florida Keys
- Golf Hotels in Florida Keys
- Green / Sustainable Hotels in Florida Keys
- Historic Hotels in Florida Keys
- Hotels with Air Conditioning in Florida Keys
- Hotels with Bar in Florida Keys
- Hotels with Breakfast in Florida Keys
- Hotels with Childcare in Florida Keys
- Hotels with Connecting Rooms in Florida Keys
- Hotels with Parking in Florida Keys
- Hotels with Pool in Florida Keys
- Hotels with Restaurant in Florida Keys
- Hotels with Spa in Florida Keys
- Hotels with WiFi in Florida Keys
- Hotels with Yoga in Florida Keys
- LGBT-Friendly Hotels in Florida Keys
- Luxury Hotels in Florida Keys
- Pet Friendly Hotels in Florida Keys
- Romantic Hotels in Florida Keys
- Ski Hotels in Florida Keys
- Wedding Hotels in Florida Keys
More accommodation types in Florida Keys
- Holiday Homes in Florida Keys
- Condo Rentals in Florida Keys
- Villas in Florida Keys
- Apartments in Florida Keys
- Cottages in Florida Keys
- Caravan Parks in Florida Keys
- Resorts in Florida Keys
- Aparthotels in Florida Keys
- Houseboats in Florida Keys
- Motels in Florida Keys
- Cabin Rentals in Florida Keys
- Guest Houses in Florida Keys
- Lodges in Florida Keys
- B&B in Florida Keys
More top Florida Keys Hotels
- Playa Largo Resort & Spa, Autograph Collection
- Delightful Aqualodge! Cabana Club Access!
- Lime Tree Bay Resort
- Bayside Inn Key Largo
- Fairfield Inn & Suites by Marriott Marathon Florida Keys
- Reefhouse Resort & Marina
- Rock Reef Resort
- Rainbow Bend Resort
- Courtyard by Marriott Faro Blanco Resort
- The Pelican Key Largo Cottages
- Drift Hotel
- Villas At Hawks Cay Resort
- Ocean Pointe Suites at Key Largo
- Coconut Cay Resort & Marina
- Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
- Yacht Haven Marina
- Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton
- La Siesta Resort & Villas
- Tranquility Bay Beachfront Hotel and Resort
- Parmer's Resort
Expedia's Latest Trends
Hotels
Flights
Cars
Packages
Holiday Rentals