5 Star Hotels in Florida Keys, United States of America

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Check availability on Florida Keys 5 Star Hotels

This weekend
5 Jun - 7 Jun
Next weekend
12 Jun - 14 Jun

Our top choices for Florida Keys 5-star hotels

On the beach, sun-loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,165 reviews)
"Beautiful hotel, grounds and wonderful staff."
United States
Anna
The price is €292
includes taxes & fees
9 Jun - 10 Jun
Isla Bella Beach Resort & Spa
Balcony

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,313 reviews)
"great place to be"
United States
oswaldo j
The price is €325
includes taxes & fees
18 Jun - 19 Jun
Cheeca Lodge & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
The price is €226 per night from 9 Jun to 10 Jun
€226
9 Jun - 10 Jun
includes taxes & fees
9.4/10 Exceptional! (1,463 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colourful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys

Top Florida Keys Hotel Reviews

Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent
"great place to be"
oswaldo j 1-night trip
Posted 1 day ago
Cheeca Lodge & Spa
Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"This property is top notch! We are in love and wish we'd found it earlier. Everyone was so nice and helpful. From registration to pool/food attendants, maintenance, . .... Everyone was so nice. The facilities are beautiful and everything you need is there! Highly recommend this resort and if we come to the Keys again, we will absolutely be staying here!!!!!"
Ginny 2-night trip
Posted 3 days ago
Isla Bella Beach Resort & Spa

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
You can find several pricing options for a 5-star hotel in Florida Keys on Expedia. The amount you pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodation for your chosen dates and make use of our pricing and other filters to score the ideal upscale stay.

  • Search for the lowest price per night from €226

What makes a hotel 5 stars in Florida Keys?
From gourmet restaurants and 24-hour gyms to pools and deluxe bedding, the 5-star experience in Florida Keys is all about comfort and indulgence. But it calls for more than just top-notch perks to earn a 5-star rating. Stays must also provide outstanding guest-focused services like in-room massage treatments, on-site laundry and dry cleaning and 24/7 room service.
Are there any 5-star all-inclusive resorts in Florida Keys?
Find an indulgent escape that includes your lodging, meals, drinks and entertainment in Florida Keys with Expedia's filters. Search for hotels rated 5 stars and click on the "All inclusive" filter. Double-check what's included in the upfront price. This way, you'll be ready to maximize all the premium perks from the moment you arrive.