Antofagasta Region Holidays

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Top destinations in Antofagasta Region

A narrow dirt road lined with buildings and trees, with people walking and a stroller visible.
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San Pedro de Atacama

San Pedro de Atacama

Top hotels in Antofagasta Region

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is €112 per night from 30 Oct to 31 Oct
€112
30 Oct - 31 Oct
8.2/10 Very good! (409 reviews)
"El único punto bajo, es el desayuno que uno lleva al tour de madrugada , es muy malo, 1 jugo en caja, 1 magdalena, 1 fruta, 1queque y sería, pésimo"

Reviewed on 20 Oct 2026

Diego de Almagro San Pedro de Atacama
Geotel Calama

Geotel Calama

3.5 out of 5
Cobija 2273 Calama Antofagasta
Fully refundableReserve now, pay when you stay
The price is €66 per night from 14 Nov to 15 Nov
€66
14 Nov - 15 Nov
8.8/10 Excellent! (242 reviews)
"Great stay, lovely breakfast. Nice and quiet and easy walk to town square. Highly recommend"

Reviewed on 16 Sept 2026

Geotel Calama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
9.2/10 Wonderful! (461 reviews)
"Great facility, friendly and very helpful staff. Good location and the views, amazing"

Reviewed on 27 Oct 2026

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Hotel La Casa de Don Tomas
See all 304 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Antofagasta Region holiday package cost?
From as low as . Yes, you read that right. Our Antofagasta Region packages are the best way to stretch your budget. Combine your hotels, flights and car rentals and discover this lively destination.
How do I get a cheap travel package to Antofagasta Region?
Our Antofagasta Region holiday packages promise plenty of savings for the savvy traveller. For the best deals, simply bundle your hotel, flights and activities into an affordable package. But impressive bargains are only the start of your next unforgettable adventure. Book with Expedia and you'll have more than 550 airlines and 1,000,000 properties throughout the world to pick from. Whatever your budget, there's a package that's perfect for you.
What are the top hotels in Antofagasta Region?
Have a look at ibis Antofagasta and NH Antofagasta. They're the first choice for lots of travellers to Antofagasta. If San Pedro de Atacama is on your travel itinerary, Park Hotel Calama and Noi Casa Atacama are cosy options.
How far in advance should I book my Antofagasta Region holiday?
It can be tricky to know when is the ideal time to book your trip to Antofagasta Region. But typically the earlier you book, the better the prices. Sometimes, you can reserve your flights and hotels up to a year before your departure date. If you're considering a last-minute getaway, no need to stress! There are fabulous deals featured on Expedia every single day.
What does an Expedia Antofagasta Region travel package include?
From hotels and airfares to rental cars, Expedia can help you shape an Antofagasta Region package that's perfect for you. Holidaying for a week or two? Consider a rental car, hotel and flight bundle. If you're taking a short break, a flight and hotel deal could be more your style. Activities can also be added once you've made your booking. Our holiday packages make it simple to save and plan.
What should I know before booking an Antofagasta Region travel package?
Tailor deals to suit your budget with an Expedia package. Airfares, hotels, rental cars — we're a one-stop shop for all of them. You'll save precious dollars just for bundling your bookings. Whether you're embarking on a skiing adventure or drinking cocktails on a beach, your perfect getaway is just clicks away.
Can I choose my airline with an Antofagasta Region Expedia holiday package?
Expedia has access to more than 550 airline partners worldwide, so you sure can! Simply select your preferred carrier and put together the perfect Antofagasta Region trip.
If I'm not able to travel, can I cancel my Antofagasta Region holiday package?
Whether it's your flight or hotel, you can cancel and rebook it. Locked in your Antofagasta Region holiday package in the last 24 hours? You may be able to make changes at no cost. For bookings older than that, you may be charged a fee by your hotel, airline or car rental company. For further information, visit our Customer Service Portal. We'll help you every step of the way.

Stay near popular Antofagasta Region attractions

Valley of the Moon

9.2/10 (244 reviews)
Treat your eyes to the variety of colors in a deserted valley that looks like a scene from a science fiction movie.
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What to do in Antofagasta Region

San Pedro de Atacama: Stargazing Experience with Transfer

San Pedro de Atacama: Stargazing Experience

€34
per adult
100% of travellers recommend
San Pedro de Atacama: Stargazing Experience
Full-Day Excursion to the El Tatio Geysers

Full-Day Excursion to the El Tatio Geysers

€55
per adult
86% of travellers recommend
Full-Day Excursion to the El Tatio Geysers
Red Stones and Altiplanica Lagoons Salar de Atacama

Red Stones and Altiplanica Lagoons Salar de Atacama

€85
per adult
Red Stones and Altiplanica Lagoons Salar de Atacama
See all activities in Antofagasta Region
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.