Holiday Rentals in Perry County

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Our top choices for Perry County holiday rentals

55-inch Smart TV with digital channels, TV, streaming services
Urban Lofts

Aparthotel in Perryville

Urban Lofts
3.0 star property
9.2 out of 10, Wonderful, (17)
"Great place to stay! "
United States
Eric
Urban Lofts
Interior
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

Apartment in Perryville

Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
10.0 out of 10, Exceptional, (1)
"Everything was perfect!"
United States
Thor L.
The price is €277
includes taxes & fees
21 Dec - 22 Dec
Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant
Interior
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques

Apartment in Perryville

Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques
2.0 star property
The price is €186
includes taxes & fees
21 Dec - 22 Dec
Urban Loft #8 METALL · Downtown Urban Loft above Restaurants & Boutiques
Outdoor spa tub
Retreat Air - King Bed, Hot Tub & No cleaning fee

Holiday Home in Perryville

Retreat Air - King Bed, Hot Tub & No cleaning fee
2.0 star property
Retreat Air - King Bed, Hot Tub & No cleaning fee
Interior
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques

Apartment in Perryville

Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques
Urban Loft #5 GRAY · Downtown Urban Loft above Restaurants & Boutiques
Fridge, microwave, oven, stovetop
Downtown Urban Loft above Restaurants

Apartment in Perryville

Downtown Urban Loft above Restaurants
2.0 star property
The price is €273
includes taxes & fees
24 Dec - 25 Dec
Downtown Urban Loft above Restaurants
Outdoor spa tub
New! Luxury Meets Nature - TreeRise at BaseCamp

Cabin in Perryville

New! Luxury Meets Nature - TreeRise at BaseCamp
2.0 star property
10.0 out of 10, Exceptional, (1)
"Our visit was short but so special. Waylon and Kaci have created a sweet haven of rest in the woods of Missouri. We so appreciated the chance to unplug for a bit. Can’t recommend enough! "
United States
Amber S.
The price is €434
includes taxes & fees
23 Dec - 24 Dec
New! Luxury Meets Nature - TreeRise at BaseCamp
Interior
Gorgeous, downtown house!

Apartment in Perryville

Gorgeous, downtown house!
10.0 out of 10, Exceptional, (1)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
The price is €766
includes taxes & fees
22 Dec - 23 Dec
Gorgeous, downtown house!
Interior
Downtown Urban Loft above Restaurants

Apartment in Perryville

Downtown Urban Loft above Restaurants
2.0 star property
The price is €273
includes taxes & fees
21 Dec - 22 Dec
Downtown Urban Loft above Restaurants
TV, fireplace
The Cottage, Rusted Route Farms

Mobile Home in Jackson

The Cottage, Rusted Route Farms
10.0 out of 10, Exceptional, (2)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The Cottage, Rusted Route Farms
Fridge, microwave, oven, stovetop
Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress

Mobile Home in Oraville

Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress
9.0 out of 10, Wonderful, (2)
"If used for hunting, maybe have a set up for cleaning of game ."
United States
john l.
The price is €172
includes taxes & fees
31 Dec - 1 Jan 2026
Kinkaid Kamper with AC in Oraville - 2 bedrooms for a cozy stay. house mattress
House (1 Bedroom) | Front of property
Lakefront, Pet-friendly 1BR w/ Porch & Fire Pit

Cottage in Murphysboro

Lakefront, Pet-friendly 1BR w/ Porch & Fire Pit
2.5 star property
Lakefront, Pet-friendly 1BR w/ Porch & Fire Pit
Fridge, microwave, oven, stovetop
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4

Cottage in Ste. Genevieve

⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
2.0 star property
10.0 out of 10, Exceptional, (18)
"Great historic property!"
United States
Rhonda R.
The price is €181
includes taxes & fees
21 Dec - 22 Dec
⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4
Outdoor dining
Beautiful location in the secluded woods

Holiday Home in Pomona

Beautiful location in the secluded woods
10.0 out of 10, Exceptional, (61)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is €143
includes taxes & fees
25 Dec - 26 Dec
Beautiful location in the secluded woods
Private kitchen
Cozy 1-bedroom house with AC and WiFi in charming Farmington

Holiday Home in Farmington

Cozy 1-bedroom house with AC and WiFi in charming Farmington
10.0 out of 10, Exceptional, (6)
"Absolutely LOVED it here! Hope to return in 2026. Karli made my first Vrbo experience just plain splendid!"
United States
Tru L.
The price is €160
includes taxes & fees
21 Dec - 22 Dec
Cozy 1-bedroom house with AC and WiFi in charming Farmington
Exterior
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Cabin in Makanda

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
9.8 out of 10, Exceptional, (60)
"The property was extremely clean and well cared for.would definitely stay again. "
United States
Dan H.
The price is €159
includes taxes & fees
31 Dec - 1 Jan 2026
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Exterior
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Cabin in Makanda

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
9.6 out of 10, Exceptional, (39)
"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."
United States
Victoria H.
The price is €187
includes taxes & fees
22 Dec - 23 Dec
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Fridge, microwave, oven, stovetop
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Holiday Home in Farmington

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
8.6 out of 10, Excellent, (4)
"Great place. "
United States
Diana
The price is €128
includes taxes & fees
5 Jan - 6 Jan 2026
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
1 bedroom, iron/ironing board, bed sheets
Beautiful Modern Loft In Wine Country!

Apartment in Ste. Genevieve

Beautiful Modern Loft In Wine Country!
10.0 out of 10, Exceptional, (271)
"Loved our stay here! Thoughtful amenities on a beautiful property. Great communication with host. "
United States
Elsie H.
The price is €158
includes taxes & fees
22 Dec - 23 Dec
Beautiful Modern Loft In Wine Country!
Fridge, microwave, oven, stovetop
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

Apartment in Cape Girardeau

Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
9.4 out of 10, Exceptional, (45)
"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"
United States
Jordan S.
The price is €122
includes taxes & fees
21 Dec - 22 Dec
Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Perry County Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Didn’t eat the breakfast but I’m sure it is wonderful. Everything from the Check in process to the condition of the rooms to the comfort of the stay was worth the money "
Corrie 1-night trip
Posted 3 days ago
Drury Plaza Hotel Cape Girardeau Conference Center

Find out more about Perry County

Holiday Homes in Perry County

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