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Our top choices for Eastern Iowa hotels

A living room with a stone fireplace, a black leather sofa, patterned armchairs, and a coffee table with decorative items.

1. Cornerstone Inn & Suites

Oelwein

Chelsey Rae

includes taxes & fees

8 Nov - 9 Nov

A restaurant with multiple tables and chairs, a stone fireplace, and framed artwork on the walls.

2. Cobblestone Inn & Suites – Manchester

Manchester

Paula

includes taxes & fees

1 Dec - 2 Dec

An indoor dining area with tables and chairs, wooden planters with plants, and hanging light fixtures.

3. Waterfront Hotel

Prairie Du Chien

Joe

includes taxes & fees

8 Nov - 9 Nov

A covered outdoor area with wooden benches and picnic tables, overlooking a river and bridge.

4. Comfort Inn & Suites Marquette - Prairie du Chien

Marquette

Mary

includes taxes & fees

22 Nov - 23 Nov

A water feature with a bear statue and a blue fish sculpture in a pool area.

5. Country Inn & Suites by Radisson, Prairie du Chien

Prairie Du Chien

Craig

includes taxes & fees

2 Dec - 3 Dec

A spacious kitchen with wooden cabinets, a dining area with wooden chairs, and a breakfast bar.

6. American Inn and Suites

Peosta

Gary

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a large bed, a desk with a computer, a TV, and a microwave.

7. Days Inn by Wyndham Evansdale Waterloo

Evansdale

Jerry

includes taxes & fees

15 Nov - 16 Nov

A spacious living area with leather sofas, a patterned rug, and a bar area with a stone backsplash.

8. Wild Rose Casino & Hotel Clinton

Clinton

Jolene

includes taxes & fees

15 Nov - 16 Nov

A modern hotel room with a kitchenette, a bed, a sofa, and a TV.

9. Microtel Inn & Suites by Wyndham Prairie du Chien

Southside

woody

includes taxes & fees

1 Dec - 2 Dec

A hotel room with two beds, a desk, a chair, a television, and artwork on the walls.

10. The Trail Inn - Amana IA

Amana

Ross

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a sofa, a small table, a desk with a chair, a television, and a window with curtains.

11. Quality Inn & Suites Decorah

Decorah

Rachelle

includes taxes & fees

29 Nov - 30 Nov

A hotel room with a large bed, a separate bathroom with a bathtub, a flat-screen TV, and a desk with a chair.

12. Cobblestone Inn & Suites - Monticello

Monticello

Julie

includes taxes & fees

5 Dec - 6 Dec

A historic building with a classic architectural style, featuring a prominent entrance with a large door and columns.

13. Hotel Winneshiek

Downtown Decorah

Joyce

includes taxes & fees

9 Nov - 10 Nov

A historic hotel with a classic brick facade, multiple storefronts including a bar and a barber shop, and a fire escape on the right.

14. The Black Hawk Hotel

Cedar Falls

Jennifer

includes taxes & fees

8 Nov - 9 Nov

A Country Inn & Suites building with a covered front porch, outdoor seating, and hanging flower baskets.

15. Country Inn & Suites by Radisson, Decorah, IA

Decorah

mary

includes taxes & fees

15 Nov - 16 Nov

A grand staircase with a red carpet leading to a second-floor area featuring a piano, a red armchair, and a chandelier.

16. Decker Hotel & Bar

Maquoketa

James

includes taxes & fees

8 Nov - 9 Nov

An outdoor patio with wicker furniture, a fire feature, and string lights.

17. Holiday Inn Express Bettendorf Davenport NE by IHG

Bettendorf

Paula

includes taxes & fees

22 Nov - 23 Nov

A spacious lobby with a central carpet design, a red sports car, and a sports lounge area.

18. Rhythm City Casino Resort

Davenport

Frances

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a bed, a desk, a television, a sofa, and a bathroom visible through an open door.

19. Days Inn by Wyndham Dubuque

Dubuque

KEVIN

includes taxes & fees

6 Dec - 7 Dec

A hotel room with two beds, a nightstand, a lamp, and a painting of windmills.

20. Super 8 by Wyndham Cresco IA

Cresco

Ryan

includes taxes & fees

15 Nov - 16 Nov

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Holiday Rentals in Eastern Iowa

Condo

A row of single-family homes with a well-maintained lawn and a tree in the foreground.

Nauvoo Vacation Villas & Condos

Nauvoo

"A great place to stay!"

Apartment

A cabin interior with wooden walls, a staircase, a bench, and a welcome sign.

Bellevue Log Cabin w/ Gas Grill & Creek Access

Bellevue

"Great hosts. This is a perfect little spot to be out of the way and have some simplicity. "

Holiday Home

A modern kitchen with white cabinets, a granite island, and pendant lighting.

New Modern Townhome With Rooftop Patio 2 Bedroom Townhouse by RedAwning

Iowa City

"Loved the rooftop deck and the extra blankets for snuggling on the coach or bed."

Apartment

A wooden cabin with a covered porch, a grill, and a chair outside.

'the Burgundy Cabin' Iowa Retreat: Pond & Fire Pit

Bellevue

"We had a great stay. The property is beautiful and fun to explore. It was perfect for our small family and we would love to rent all the space for a family get together in the future. We were there during the holidays and the cabin was decorated perfectly. "

Cottage

A two-story house with a front porch, a staircase, and a well-maintained lawn.

Cozy Iowa Getaway w/ Patio & Fenced-in Yard!

Dyersville

"We had a wonderful stay! The home was very clean, welcoming, and had everything we needed. We especially loved how well-stocked the kitchen was, making it easy to prepare meals and feel right at home. The beds were incredibly comfortable, which made for a great night’s sleep. We also loved the convenience of the keypad check-in—it made arriving and getting settled so easy! Overall, it was a fantastic experience, and we would definitely stay here again. Highly recommend!"

Cottage

A dining room with a marble table, wooden chairs, a vase with flowers, and a chandelier.

1 Mi to Downtown Dubuque! Spacious Home

Dubuque

"Great location close to several schools and no more than a 10 minute drive to most places around town. House was very comfortable and well stocked with everything we needed. Beds were also very comfy."

Cottage

A modern kitchen with a central island, bar stools, a chandelier, and a dining area with chairs.

Walk Downtown: Inviting Historic Home in Dubuque!

Downtown Dubuque

"This is a wonderful property in a perfect location! Easily walk to restaurants, attractions and the farmer’s market when it’s running. The hosts were very responsive and accommodating."

Cottage

A two-story brick building with a central entrance, a gabled roof, and a symmetrical facade.

< 1 Mi to Downtown: Historic Dubuque Gem!

Dubuque

"Little warm in back room, little nervous about neighborhood but differently diamond in rough"

Apartment

A kitchen with wooden cabinets, stainless steel appliances, a window with a blue valance, and a built-in oven.

Welcoming Condo in Davenport: Central Location!

Davenport

"Great stay. Clean with plenty of room for multiple travelers. Host was quick to respond with answers to questions we had. Would definitely stay again if available!"

Cottage

A house with a patio area featuring a wicker sofa, a barbecue grill, and a stone fire pit.

Steps to Mississippi River: Cozy Hot Tub Haven!

Le Claire

"We had such a wonderful stay at this cozy Mississippi River retreat! The location was perfect — just steps from the river with peaceful views and a relaxing atmosphere. The hot tub was the perfect touch after a long day, and the home itself was spotless, comfortable, and beautifully welcoming. Everything felt thoughtfully prepared, making it easy to relax and enjoy every moment. We would absolutely stay here again!"

Holiday Home

A modern kitchen with white cabinetry, a granite island, and pendant lighting.

New Modern Townhome With Rooftop Patio 2 Bedroom Townhouse by RedAwning

Iowa City

"This townhome was absolutely perfect for UofI graduation in May! The location was 2 blocks from commencement making it ideal for every type of event associated with the university. The accommodations included every detail possible - tastefully decorated, a roomy main level kitchen/living area for entertaining (including serving pieces of perfection!). The rooftop included a grill and fire table to allow us to enjoy the outdoors and an awesome view of the area. Thank you for making graduation...

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Stay near popular Eastern Iowa attractions

A large white house with a grey roof, surrounded by a white picket fence and green bushes.

Field of Dreams

9.4/10 (162 reviews)

You can spend time exploring the galleries in Field of Dreams in Dyersville. Experience the area's entertainment choices and live music.

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Learn more about Eastern Iowa

Explore the banks of the great Mississippi River and discover the life that has erupted from it. Museums, panoramas and plenty of fresh air await you.

See all hotels in Eastern Iowa

The National Mississippi River Museum & Aquarium entrance with a large blue sign, a brick building, and a covered entrance area.

Top Eastern Iowa Hotel Reviews

Wyndham Moline on John Deere Commons

10/10 Excellent

"Spacious, comfortable, quiet, reasonable....close to everything"

Grand Harbor Resort

10/10 Excellent

"This was a deal! Got much more than room-breakfast and access to water park. Lots of families but it seems like adult travelers they put on top floor so a little quiet. Was right next to event center where we were attending a show and right next to Tony Roma restaurant so very convenient. We didn't go to casino but that was right across the parking lot (walking distance). Would definitely stay here again!"