Default HTG hotel image

Edisto Island Hotel Guide - Edisto Island Serpentarium hotels in Edisto Island, United States of America.

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
3 Oct - 4 Oct
Tomorrow
4 Oct - 5 Oct
Next weekend
9 Oct - 11 Oct
In two weeks
16 Oct - 18 Oct

Filter by

Star rating

Guest rating

Top Edisto Island Serpentarium Hotel Reviews

Ocean Front Home with Breath Taking Views!

Ocean Front Home with Breath Taking Views!

10/10 Excellent
"Overall great , elevator is a must-have,we will be staying again"
Robert S. 3-night trip
Posted 2 days ago
Ocean Front Home with Breath Taking Views!
Oceanfront Showplace - Island Manor

Oceanfront Showplace - Island Manor

8/10 Good
"Communication was great, they responded quickly when I had a question. View from the home was gorgeous, the beach was right there! Loved the outdoor shower and hose for cleaning sandy feet, beach items, and fishing gear. Kitchen was well stocked. Bathrooms were clean and spacious. There was a great deal of furniture though, lots of end tables and extra chairs, which made it a little crowded. But we were very thankful to have found a home that could accommodate our large group!"
Melissa B. 7-night trip
Posted 5 days ago
Oceanfront Showplace - Island Manor
Luxury 5BR Oceanview ~ Chiltren By the Sea

Luxury 5BR Oceanview ~ Chiltren By the Sea

10/10 Excellent
"Beautiful home, excellent location. Perfect for all ages. We will be back!"
Lauren G. 2-night trip
Posted 5 days ago
Luxury 5BR Oceanview ~ Chiltren By the Sea
Gorgeous Secluded Island W/Creek & Ocean View w/DOCK & swim!  Pet-friendly/Wi-Fi

Gorgeous Secluded Island W/Creek & Ocean View w/DOCK & swim! Pet-friendly/Wi-Fi

10/10 Excellent
"Amazing views!!"
Brooke C. 3-night trip
Posted 2 weeks ago
Gorgeous Secluded Island W/Creek & Ocean View w/DOCK & swim! Pet-friendly/Wi-Fi
3 bedroom elevated chic home tucked among the trees~ The Paper House

3 bedroom elevated chic home tucked among the trees~ The Paper House

10/10 Excellent
"We love this place! Second year in a row that we've booked, and it never disappoints. Clean, spacious, and quiet! See you next year!"
James R. 2-night trip
Posted 3 weeks ago
3 bedroom elevated chic home tucked among the trees~ The Paper House
Newly renovated beachfront house w/Patio, Free WiFi, Private W/D, AC

Newly renovated beachfront house w/Patio, Free WiFi, Private W/D, AC

8/10 Good
"It was a nice place and nice location. Had an issue with the stove not working properly and water pressure wasnt very good in the showers and had no propane in the grill. Outside of those issues. It was a nice place and a nice stay"
Jeremy B. 3-night trip
Posted 1 month ago
Newly renovated beachfront house w/Patio, Free WiFi, Private W/D, AC
Pink Bird Cottage

Pink Bird Cottage

10/10 Excellent
"A"
william w. 4-night trip
Posted 1 month ago
Pink Bird Cottage
Sulla Sabbia-Oceanfront Bungalow;Stunning Ocean/Sunrise Views;Walk to Shops/Restaurants

Sulla Sabbia-Oceanfront Bungalow;Stunning Ocean/Sunrise Views;Walk to Shops/Restaurants

8/10 Good
"It was a little pricey but a beautiful home. Loved the location! I wished they had a bigger deck instead of two small decks. I would definitely stay here again. Also, couldn't get cooler water in any if the showers."
Anonymous traveller 2-night trip
Posted 2 months ago
Sulla Sabbia-Oceanfront Bungalow;Stunning Ocean/Sunrise Views;Walk to Shops/Restaurants
Water Front Edisto with Private Dock 
On Deep Creek overlooking the Ocean

Water Front Edisto with Private Dock On Deep Creek overlooking the Ocean

10/10 Excellent
"This home was incredible. It was well appointed and easily accommodated 13 members of our family. The large screened in porch overlooking the water was a popular gathering place. We couldn’t have asked for a better, more welcoming experience."
RS5 6-night trip
Posted 3 months ago
Water Front Edisto with Private Dock On Deep Creek overlooking the Ocean

Other attractions near Edisto Island Serpentarium

Botany Bay Plantation

8.8/10 (25 reviews)
Explore the great outdoors at Botany Bay Plantation, a lovely green space in Edisto Island. Stroll along the beaches in this relaxing area or seek out the fishing spots.
See properties

With These Hands Gallery

8.0/10 (5 reviews)
You can spend time studying the exhibits at With These Hands Gallery during your travels in Edisto Island. Stroll along the beautiful beaches in this relaxing area or seek out the cycling trails.
See properties

Botany Bay Plantation Heritage Preserve and Wildlife Management Area

9.2/10 (13 reviews)
Explore the lovely green spaces of Botany Bay Plantation Heritage Preserve and Wildlife Management Area and enjoy the cycling trails in Edisto Island. Wander the beautiful beaches in this relaxing area.
See properties

Edisto Island Museum

8.4/10 (6 reviews)
You can spend time studying the exhibits at Edisto Island Museum during your trip to Edisto Island. Wander the beautiful beaches in this relaxing area.
See properties

Edisto Beach State Park

9.0/10 (75 reviews)
You can take time to visit Edisto Beach State Park during your travels to Edisto Island. Wander the beautiful beaches in this relaxing area.
See properties

Bay Creek Park

Explore the great outdoors at Bay Creek Park, a lovely green space in Edisto Island. Wander the beaches and seaside while you're in the area.
See properties

beach near Spinnaker Beachhouses

Why not spend a lazy afternoon at beach near Spinnaker Beachhouses during your trip to Seabrook Island? Stroll along the marina or discover the sunsets in this relaxing area.
See properties

Plantation Course at Edisto

8.6/10 (7 reviews)
Enjoy a round of golf in Edisto Island at Plantation Course at Edisto. Wander the beautiful beaches in this relaxing area.
See properties

Frequently asked questions

What's the area like around Edisto Island Serpentarium?
Edisto Island Serpentarium is located in an area of Edisto Island known for its beautiful beaches. You'll find 192 hotels and other accommodations within a few miles for a convenient home base.
How many hotels are there near Edisto Island Serpentarium?
Expedia has 192 hotels and other accommodation options a few miles from Edisto Island Serpentarium.
If I need to cancel the hotel reservation for my stay near Edisto Island Serpentarium, will I receive a refund?
Yes! You'll find that most room reservations are refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If you have a reservation that's non-refundable, you might still have the option to cancel and receive a refund within 24 hours of booking. Enter your dates, click on "Search", then filter by "fully refundable" to get the best deals available near Edisto Island Serpentarium.
What can I see and do near Edisto Island Serpentarium?
Attractions like With These Hands Gallery and Edisto Island Museum highlight the local culture. You might plan a visit to Edisto Beach State Park or Botany Bay Plantation Heritage Preserve and Wildlife Management Area while you're in the area. You might also stop by Bohicket Marina, located 7.9 mi from Edisto Island Serpentarium, or Freshfields Village which is 8.3 mi away.