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Key West Hotel Guide - Florida Keys National Marine Sanctuary hotels in Key West, United States of America.

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Check prices for these dates

This weekend
19 Jun - 21 Jun
Next weekend
26 Jun - 28 Jun

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Our top choices for Florida Keys National Marine Sanctuary hotels

Queen Deluxe ADA

Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
10.0 out of 10, Exceptional, (1,017 reviews)
"Excellent accommodations"
United States
Jimmy
The price is €218
includes taxes & fees
22 Jun - 23 Jun
Almond Tree Inn Hotel - Adults Only
Property grounds

Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
3.5 star property
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,014 reviews)
"Great boutique hotel in the perfect location !! "
United States
Michael
The price is €212
includes taxes & fees
21 Jun - 22 Jun
Orchid Key Inn - Adults Only
Queen with Pool View

Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
2.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (983 reviews)
"Perfcet location and walk to everything , we very much enjoyed our stay!"
United States
Rita
The price is €145
includes taxes & fees
17 Jun - 18 Jun
Simonton Court Historic Inn & Cottages
Exterior detail

The Gardens Hotel

The Gardens Hotel
4.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,007 reviews)
"Whole place is great"
United States
Joseph
The price is €232
includes taxes & fees
28 Jun - 29 Jun
The Gardens Hotel
Front of property

Key West Villas

Key West Villas
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (262 reviews)
"This was the best place we have stayed at in Key West! It was super quiet but only a block from Duval. The owners really put a lot of care into the place and are super nice! Definitely would stay there again! "
United States
Jennifer
The price is €200
includes taxes & fees
18 Jun - 19 Jun
Key West Villas
Restaurant

Artist House Key West

Artist House Key West
3.5 star property
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (441 reviews)
"Great atmosphere and location."
United States
NATHAN
The price is €152
includes taxes & fees
23 Jun - 24 Jun
Artist House Key West
Exterior

The Marquesa Hotel

The Marquesa Hotel
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (1,003 reviews)
"Friendly and helpful staff, and the rooms were exceptionally clean and comfortable. Everything was well-maintained, and the overall experience was wonderful. I will definitely be coming back again!"
United States
Helia
The price is €271
includes taxes & fees
30 Jun - 1 Jul
The Marquesa Hotel
11 Gecko's Garden - Adults Only

Tropical Inn

Tropical Inn
3.5 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (410 reviews)
"Very friendly staff and a prime location."
United States
Akhenaton
The price is €175
includes taxes & fees
17 Jun - 18 Jun
Tropical Inn
Veranda Room | Terrace/patio

The Conch House Heritage Inn

The Conch House Heritage Inn
3.5 star property
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (177 reviews)
"Great location "
United Kingdom
Lucy
The price is €231
includes taxes & fees
18 Jun - 19 Jun
The Conch House Heritage Inn
Premium bedding, iron/ironing board, free WiFi, bed sheets

Weatherstation Inn

Weatherstation Inn
2.5 star property
Truman Annex, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,003 reviews)
"Quaint place to stay with access to there other more resort style property made for an amazing experience."
United States
Bret
The price is €174
includes taxes & fees
28 Jun - 29 Jun
Weatherstation Inn
Exterior

Douglas House - Adults Only

Douglas House - Adults Only
3.0 star property
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (422 reviews)
"Great stay"
United States
Matthew
The price is €133
includes taxes & fees
23 Jun - 24 Jun
Douglas House - Adults Only
Deluxe Suite, 1 King Bed, Private Pool | View from room

H2O Suites - Adults Only

H2O Suites - Adults Only
3.5 star property
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
9.8 out of 10, Exceptional, (613 reviews)
"Excellent stay. Very quiet and great location. Staff was excellent and so was housekeeping. We will definitely return."
United States
Rosa
The price is €378
includes taxes & fees
6 Jul - 7 Jul
H2O Suites - Adults Only
Exterior

Coco Plum Inn

Coco Plum Inn
3.0 star property
Downtown Key West, 0.6 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (536 reviews)
"Loved the property and staff was super friendly."
United States
Brinkley
The price is €174
includes taxes & fees
12 Jul - 13 Jul
Coco Plum Inn
Front of property

L'Habitation Guest House

L'Habitation Guest House
2.5 star property
Historic Seaport, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (994 reviews)
"Loved the location, breakfast and clean room. Staff, Drew, very friendly and helpful. Will definitely stay here again."
United States
Richard
The price is €116
includes taxes & fees
18 Jun - 19 Jun
L'Habitation Guest House
Cigar House King Suite w/ Poolside porch | Balcony view

Island City House Hotel

Island City House Hotel
3.0 star property
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,007 reviews)
"I love this Hotel. Great location, safe m, convenient. The staff is very accommodating."
United States
Paul
The price is €168
includes taxes & fees
17 Jun - 18 Jun
Island City House Hotel
Property grounds

Duval House

Duval House
3.0 star property
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,046 reviews)
"Great location and clean rooms. Breakfast staff is so sweet! Will stay here again for sure!!"
United States
Wendy S
The price is €153
includes taxes & fees
23 Jun - 24 Jun
Duval House
Terrace/patio

Marrero's Guest Mansion

Marrero's Guest Mansion
3.5 star property
Downtown Key West, 0.7 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (337 reviews)
"It was nice. Get a smart tv 😂"
United States
Robert
The price is €194
includes taxes & fees
13 Jul - 14 Jul
Marrero's Guest Mansion
3 outdoor pools, a heated pool, pool loungers

Ambrosia Key West

Ambrosia Key West
3.5 star property
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
9.4 out of 10, Exceptional, (1,009 reviews)
"Great location and breakfast"
United States
Lori
The price is €174
includes taxes & fees
17 Jun - 18 Jun
Ambrosia Key West
2 outdoor pools, pool loungers

Santa Maria Suites

Santa Maria Suites
4.0 star property
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
9.6 out of 10, Exceptional, (1,003 reviews)
"Great stay"
United States
Steven
The price is €358
includes taxes & fees
21 Jun - 22 Jun
Santa Maria Suites
Porch

Heron House - Adult Only

Heron House - Adult Only
3.5 star property
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
9.2 out of 10, Wonderful, (1,169 reviews)
"Hotel was amazing and breakfast was delicious!"
United States
Cameron
The price is €144
includes taxes & fees
17 Jun - 18 Jun
Heron House - Adult Only
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Queen Deluxe ADA
Almond Tree Inn Hotel - Adults Only
3.5 star property
10.0
Exceptional
1,017 reviews
View
Property grounds
Orchid Key Inn - Adults Only
3.5 star property
9.8
Exceptional
1,014 reviews
View
Queen with Pool View
Simonton Court Historic Inn & Cottages
2.5 star property
9.8
Exceptional
983 reviews
View
Exterior detail
The Gardens Hotel
4.0 star property
9.8
Exceptional
1,007 reviews
View
Front of property
Key West Villas
3.5 star property
9.8
Exceptional
262 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

10/10 Excellent
"This hotel was excellent. The staff was phenomenal. We stayed in a lot of hotels and I think this staff was the best group of people ever, they helped with everything and were sincerely nice with great attitudes. The rooms were clean and the water view was fabulous. The entire property was neat and clean. Breakfast was really good. Our week here was such a delight. I would stay here again in a heartbeat."
Tempsie 6-night trip
Posted 1 hour ago
Opal Key Resort & Marina, Key West

Hotels near other Florida Keys National Marine Sanctuary attractions

Florida Keys Eco - Discovery Center

8.8/5 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
See properties

Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1542 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Caribbean House is one of the top choices for your stay based on our traveller data, and this B&B offers free breakfast and private balconies. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1542 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Audubon House and Tropical Gardens are some of the notable landmarks to see in the area. You can watch performances at Waterfront Playhouse, Key West Film Society and Red Barn Theater if you're interested in local theatre.