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Key West Hotel Guide - Florida Keys National Marine Sanctuary hotels in Key West, United States of America.

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Tonight
21 Sept - 22 Sept
Tomorrow
22 Sept - 23 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

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Our top choices for Florida Keys National Marine Sanctuary hotels

A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
A building with a sign reading "ALMOND Frog & Toad Inn" and a "VACANCY" sign below it.
A reception area with a wooden herringbone wall, teal chairs, a wooden bench, and two framed sunset paintings.
A swimming pool with lounge chairs, surrounded by palm trees and greenery.

1. Almond Tree Inn Hotel - Adults Only

Almond Tree Inn Hotel - Adults Only
Downtown Key West, 0.9 km from Florida Keys National Marine Sanctuary
United States
John
€165
includes taxes & fees
27 Sept - 28 Sept
Almond Tree Inn Hotel - Adults Only
A modern interior with a staircase, a sofa set, a wooden table, and a television.
A pool area with a clear view of a house in the background, surrounded by palm trees and greenery.
A spacious room with a large bed, a sofa, a chair, a small table, and a television.
A pathway flanked by lush green foliage leading to a gated entrance.

2. Simonton Court Historic Inn & Cottages

Simonton Court Historic Inn & Cottages
Historic Seaport, 1 km from Florida Keys National Marine Sanctuary
United States
Robin
€175
includes taxes & fees
23 Sept - 24 Sept
Simonton Court Historic Inn & Cottages
A porch with a white railing, a bench, and a flag.
A living room with a sofa, a glass coffee table, a TV, and a painting on the wall.
A pool area with lounge chairs and a dining table, surrounded by palm trees and a house with a porch.
A spacious bedroom with a large bed, a sitting area with a sofa and armchairs, and a dining area with a table and chairs.

3. The Conch House Heritage Inn

The Conch House Heritage Inn
Old Town Key West, 1.1 km from Florida Keys National Marine Sanctuary
United States
John
€136
includes taxes & fees
29 Sept - 30 Sept
The Conch House Heritage Inn
A pool area with lounge chairs and a table, surrounded by palm trees.
A neon sign for Orchid Key Inn with a 'VACANCY' sign below it.
A building with a neon sign that reads "Orchid Key Inn."
A patio with a white wicker lounge chair, a wooden table with a book and a potted plant, surrounded by lush tropical foliage and palm trees.

4. Orchid Key Inn - Adults Only

Orchid Key Inn - Adults Only
Uptown - Upper Duval, 0.8 km from Florida Keys National Marine Sanctuary
United States
Nicholas
€157
includes taxes & fees
27 Sept - 28 Sept
Orchid Key Inn - Adults Only
A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.
A bar area with a counter, chairs, and a clock.
A bedroom with a large bed, a television on a dresser, and a view of the outdoors through a sliding door.
A couple walking along a poolside pathway surrounded by lush greenery.

5. The Gardens Hotel

The Gardens Hotel
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Robert
€219
includes taxes & fees
30 Sept - 1 Oct
The Gardens Hotel
A two-story house with a covered porch, a brick pathway, and a large tree.
A poolside area with a swimming pool, a staircase leading to a deck, and a building with multiple windows and balconies.
A restaurant with multiple tables set for dining, a wine bottle, and a glass of wine on the table.
A hotel room with two beds, a ceiling fan, a large window with a view of palm trees, and a painting on the wall.

6. The Marquesa Hotel

The Marquesa Hotel
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
Darrell
€273
includes taxes & fees
23 Sept - 24 Sept
The Marquesa Hotel
A modern hotel room with a white sofa, a zebra-patterned rug, and a large mirror above the sofa.
A pool area with lounge chairs, a pool, and a building with a balcony and outdoor seating.
A spacious living room with a wooden ceiling, white sofas, a patterned armchair, a glass coffee table, and a large painting on the wall.
A narrow room with a bed, a potted plant, and a window with blinds.

7. Alexander's Guesthouse - Adult Exclusive

Alexander's Guesthouse - Adult Exclusive
Old Town Key West, 1.7 km from Florida Keys National Marine Sanctuary
United States
Nestor
€249
includes taxes & fees
27 Sept - 28 Sept
Alexander's Guesthouse - Adult Exclusive
A gated entrance to Villas Key West with a brick pathway leading to the gate.
A swimming pool with a hot tub, surrounded by a wooden deck and lush greenery.
A house with a porch, a table, and a door with a number '6'.
A covered porch with wicker furniture, a large potted plant, and a sign for Villas Key West.

8. Key West Villas

Key West Villas
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Margaret
€255
includes taxes & fees
15 Oct - 16 Oct
Key West Villas
A tropical outdoor area with palm trees, hanging plants, and string lights.
A wooden deck with lush greenery and a pool area.
A large, two-story building with a balcony, surrounded by dense tropical foliage.
A hotel room with a bed, a wooden floor, a seating area with a table and chairs, and a view of greenery outside.

9. Douglas House - Adults Only

Douglas House - Adults Only
Uptown - Upper Duval, 0.9 km from Florida Keys National Marine Sanctuary
United States
michael
€110
includes taxes & fees
24 Sept - 25 Sept
Douglas House - Adults Only
A modern outdoor area with a pool, lounge chairs, and a bar area.
A bar area with a modern design, featuring a flat-screen TV mounted on a textured wall, two stools, and a bar stocked with various bottles.
A modern hotel room with a bed, sofa, coffee table, and artwork.
An outdoor seating area with a modern fire feature, surrounded by lush greenery and palm trees.

10. H2O Suites - Adults Only

H2O Suites - Adults Only
Uptown - Upper Duval, 1.1 km from Florida Keys National Marine Sanctuary
United States
Kourosh
€332
includes taxes & fees
27 Sept - 28 Sept
H2O Suites - Adults Only
A wooden deck with white railings, surrounded by lush greenery and a staircase leading to a building.
A two-story building with a white picket fence, a mailbox, and a small tree in front.
A swimming pool with a mural of a dolphin and a butterfly, surrounded by lounge chairs and palm trees.
A hallway with a white door, a wooden bench, a blue sofa, and a staircase with a white railing.

11. Duval House

Duval House
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Anne
€116
includes taxes & fees
27 Sept - 28 Sept
Duval House
A bedroom with a four-poster bed, a wooden desk, wicker chairs, and a view of the outdoors.
A pool area with lounge chairs and candles, surrounded by palm trees and a building in the background.
A cozy room with a wicker chair, a small table with a bottle and glasses, and a view of a yellow room through an open door.
A wooden door with glass panels, leading to an interior space with furniture and plants.

12. Tropical Inn

Tropical Inn
Downtown Key West, 0.8 km from Florida Keys National Marine Sanctuary
United States
Molly
€116
includes taxes & fees
27 Sept - 28 Sept
Tropical Inn
A wooden deck with a hammock, pool, and lounge chairs overlooking a tropical garden.
A covered walkway with a wooden ceiling, white railings, and a brick path.
A compact kitchen with wooden cabinets, a microwave, stove, and refrigerator. There is a dining area with a table and chairs, and a sofa.
A garden with a pond, rocks, and various plants.

13. Island City House Hotel

Island City House Hotel
Historic Seaport, 1.2 km from Florida Keys National Marine Sanctuary
United States
Osvaldo
€151
includes taxes & fees
23 Sept - 24 Sept
Island City House Hotel
A narrow outdoor pathway flanked by potted plants and a wooden staircase leading to a white door with shutters.
A bedroom with a bed, nightstand, lamp, air conditioning unit, and a no smoking sign.
A two-story building with a porch, a sign reading "The Grand Guesthouse," and a purple flag.
A row of blue bicycles parked under a tree, with a white fence and a building in the background.

14. The Grand Guesthouse

The Grand Guesthouse
Old Town Key West, 1.6 km from Florida Keys National Marine Sanctuary
United States
Alissa
€132
includes taxes & fees
23 Sept - 24 Sept
The Grand Guesthouse
A room with a bed, a ceiling fan, and a window with blinds.
A cozy outdoor seating area with a wooden bench and a table, surrounded by potted plants and a coffee and tea sign.
A poolside area with lounge chairs, a covered seating area, and a small pool.
A spacious kitchen with wooden cabinets, a granite countertop, and a ceiling fan.

15. The Mermaid & Alligator

The Mermaid & Alligator
Old Town Key West, 1.2 km from Florida Keys National Marine Sanctuary
United States
Brian
€176
includes taxes & fees
28 Sept - 29 Sept
The Mermaid & Alligator
A pool area with lounge chairs and palm trees.
A sign for Santa Maria Resort surrounded by lush greenery and palm trees.
A hotel named "Santa Maria" with a prominent illuminated sign, a glass entrance, and a view of the ocean.
A reception area with a modern design, featuring a reception desk, a sofa, and a potted plant.

16. Santa Maria Suites

Santa Maria Suites
Uptown - Upper Duval, 1.3 km from Florida Keys National Marine Sanctuary
United States
Anthony
€332
includes taxes & fees
23 Sept - 24 Sept
Santa Maria Suites
A reception area with a curved marble counter, ceiling fans, large windows, and a staircase.
A two-story house with a white exterior, a green roof, and a staircase leading to the upper floor.
A bedroom with a bed, two bedside lamps, a ceiling fan, and a view of a balcony with plants.
A breakfast table with a variety of food items, including fruits, pastries, and a coffee mug.

17. Westwinds Inn

Westwinds Inn
Historic Seaport, 1.4 km from Florida Keys National Marine Sanctuary
United States
Tricia
€114
includes taxes & fees
23 Sept - 24 Sept
Westwinds Inn
A room with a door featuring horizontal blinds, a visible outdoor view through the window, and a patterned carpet.
A yellow building with a door marked '7'.
A garden with a stone pathway, a wooden fence, and various tropical plants.
A pool area with a covered seating area, palm trees, and a small pavilion.

18. Alexander Palms Court

Alexander Palms Court
Casa Marina, 1.4 km from Florida Keys National Marine Sanctuary
United States
Andrew
€117
includes taxes & fees
23 Sept - 24 Sept
Alexander Palms Court
A swimming pool with water splashing, surrounded by palm trees and a building in the background.
A two-story yellow house with a porch, white railings, and green shutters.
The exterior of the Silver Palms Inn with a two-story structure, a green awning over the entrance, and a palm tree to the right.
A hotel with a pool, bicycles, and lush greenery.

19. Silver Palms Inn & Historic Homes

Silver Palms Inn & Historic Homes
Old Town Key West, 1.3 km from Florida Keys National Marine Sanctuary
United States
sam
€137
includes taxes & fees
23 Sept - 24 Sept
Silver Palms Inn & Historic Homes
A rectangular pool with a white deck, surrounded by lush greenery and a gazebo.
A wicker outdoor seating area with two chairs and a table, surrounded by lush tropical foliage.
A hotel room with a bed, a nightstand, a chair, a small table, and a ceiling fan.
A cozy living room with a wooden ceiling, a sofa set, two side tables with lamps, and framed artwork on the wall.

20. Ambrosia Key West

Ambrosia Key West
Old Town Key West, 1 km from Florida Keys National Marine Sanctuary
United States
Tricia
€132
includes taxes & fees
27 Sept - 28 Sept
Ambrosia Key West
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Compare popular hotels close to Florida Keys National Marine Sanctuary

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A modern hotel room with a large bed, a nightstand, a bedside table, and a bathroom visible through an open door.
Almond Tree Inn Hotel - Adults Only
10.0
Exceptional
1,006 reviews
View
A modern interior with a staircase, a sofa set, a wooden table, and a television.
Simonton Court Historic Inn & Cottages
9.8
Exceptional
1,000 reviews
View
A porch with a white railing, a bench, and a flag.
The Conch House Heritage Inn
9.8
Exceptional
189 reviews
View
A pool area with lounge chairs and a table, surrounded by palm trees.
Orchid Key Inn - Adults Only
9.8
Exceptional
1,001 reviews
View
A garden pathway leading to a white gazebo with pink flowers, surrounded by lush greenery and a white fence.
The Gardens Hotel
9.8
Exceptional
1,004 reviews
View

Top Florida Keys National Marine Sanctuary Hotel Reviews

The Cabana Inn Key West - Adults Only

The Cabana Inn Key West - Adults Only

10/10 Excellent
"Great stay. Clean and well Maintained. Friendly staff."
ALEASE 3-night trip
Posted 5 hours ago
The Cabana Inn Key West - Adults Only
Douglas House - Adults Only

Douglas House - Adults Only

10/10 Excellent
"We spent a weekend at Douglas House. Very convenient. The staff was amazing and very knowledgeable. We will stay there again"
Penny 1-night trip
Posted 5 hours ago
Douglas House - Adults Only
Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses

10/10 Excellent
"A little annoyed at the gate that got locked (leading us to our room), and that the gate was not repaired during our stay, but that was the only real issue out of the entire stay."
Nicholas James 6-night trip
Posted 8 hours ago
Southernmost Beach Resort and Guesthouses
Winslow's Bungalows - Key West Historic Inns

Winslow's Bungalows - Key West Historic Inns

10/10 Excellent
"The room was clean and decorated for the keys. Breakfast was amazing. Take advantage of that. The location is great for getting to so many hotspots."
Michael 2-night trip
Posted 10 hours ago
Winslow's Bungalows - Key West Historic Inns
Southwinds Motel

Southwinds Motel

8/10 Good
"The room was clean and the staff very helpful"
Tony 2-night trip
Posted 12 hours ago
Southwinds Motel
Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West

10/10 Excellent
"Always love staying at the Opal."
SHANNON 6-night trip
Posted 14 hours ago
Opal Key Resort & Marina, Key West
The Southernmost Inn - Adults Only

The Southernmost Inn - Adults Only

10/10 Excellent
"Nos gustó todo en general muy bueno , Lo único para agregar es que en el desayuno no había ni queso ni jamón cocido algo que estaría muy bueno agregar Saludos Cordiales"
Jorge 2-night trip
Posted 2 days ago
The Southernmost Inn - Adults Only
Steps from Duval, Pool on Site & Bikes Included!

Steps from Duval, Pool on Site & Bikes Included!

8/10 Good
"Clean room-great location and the bikes were a plus!"
Jonna J. 4-night trip
Posted 3 days ago
Steps from Duval, Pool on Site & Bikes Included!
Weatherstation Inn

Weatherstation Inn

10/10 Excellent
"The staff and the location are perfect"
Robert 1-night trip
Posted 6 days ago
Weatherstation Inn

Other attractions near Florida Keys National Marine Sanctuary

An aquarium exhibit with fish tanks and informational displays.

Florida Keys Eco - Discovery Center

8.8/10 (128 reviews)
Learn about the area’s important marine ecology at this comprehensive attraction that addresses global environmental concerns, interesting for visitors of all ages.
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A coastal fortification with a staircase leading to a higher platform, overlooking the sea.

Fort Zachary Taylor Historic State Park

9.0/10 (4,544 reviews)
The displays of old weapons and interpretive panels in a fort at the heart of the southernmost state park in the continental U.S. provide information about the Civil War.
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A wooden signpost with directional arrows pointing to various cities and their distances.
Photo by Martin Pettersson

Truman Beach

Why not spend a lazy afternoon at Truman Beach during your trip to Key West? Stroll along the seaside or discover the area's beautiful sunsets.
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The Monroe County Courthouse with a clock tower, surrounded by trees and a clear blue sky.

Jackson Square

8.8/10 (110 reviews)
You can learn about the history of Key West with a trip to Jackson Square. Stroll along the seaside or discover the area's beautiful sunsets.
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Coffee Butler Amphitheater

You can make plans for a show at Coffee Butler Amphitheater during your trip to Key West. Discover the area's lively bars and its entertainment choices.
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USCGC Ingham Maritime Museum

You can spend an afternoon browsing the exhibits at USCGC Ingham Maritime Museum during your trip to Key West.
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Truman Waterfront Park

You can take time to visit Truman Waterfront Park during your travels to Key West. Discover the area's lively bars and its entertainment choices.
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We Cycle Key West

You can do some window-shopping at We Cycle Key West during your stay in Key West.
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Frequently asked questions

What's the area like around Florida Keys National Marine Sanctuary?
Florida Keys National Marine Sanctuary is located in an area of Key West known for its beautiful ocean views, cycling and lively festivals. If you're looking for a convenient place to stay, take a look at the 1501 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Florida Keys National Marine Sanctuary?
Adjacent to Florida Keys National Marine Sanctuary, Tranquility Guest House is one of the top choices for your stay based on our traveller data, and this hotel offers an outdoor pool and free WiFi. Other good choices close by include Southernmost Beach Resort and Guesthouses and La Concha Key West, Autograph Collection.
How many hotels will I find near Florida Keys National Marine Sanctuary?
Expedia has 1501 hotels and other accommodation options within a mile from Florida Keys National Marine Sanctuary.
If I need to cancel the hotel reservation for my stay near Florida Keys National Marine Sanctuary, will I receive a refund?
Yes, most hotel reservations are fully refundable if cancelled before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If you have a non-refundable reservation, you may still be able to cancel and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then use the filter option "fully refundable" to get the best deals near Florida Keys National Marine Sanctuary.
What can I see and do near Florida Keys National Marine Sanctuary?
Florida Keys Eco - Discovery Center, Harry S. Truman Little White House and Key West Lighthouse and Keeper's Quarters Museum feature captivating exhibits. Fort Zachary Taylor Historic State Park, Ernest Hemingway Home and Museum and Fort East Martello Museum and Gallery are some of the notable landmarks to see in the area. You can watch performances at Red Barn Theater, Waterfront Playhouse and Coffee Butler Amphitheater if you're interested in local theatre.