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Cairo Hotel Guide - Fort Defiance State Park hotels in Cairo, United States of America.

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Check prices for these dates

Tonight
28 Sept - 29 Sept
Tomorrow
29 Sept - 30 Sept
This weekend
2 Oct - 4 Oct
Next weekend
9 Oct - 11 Oct

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Our top choices for Fort Defiance State Park hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
A reception desk with a computer, a framed picture on the wall, and a vase with flowers.
A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.
A motel with a red roof and beige walls, a parking lot, and a signboard.

1. La Center Motel

La Center Motel
17.5 km from Fort Defiance State Park
United States
Carrie
€50
includes taxes & fees
29 Sept - 30 Sept
La Center Motel
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
17.5 km from Fort Defiance State Park
United States
William
€58
includes taxes & fees
29 Sept - 30 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
20.2 km from Fort Defiance State Park
United States
France
€65
includes taxes & fees
1 Oct - 2 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel lobby with a reception desk, seating area, and a large window.
A hotel room with a desk, chair, television, and a lamp.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
7.8 km from Fort Defiance State Park
United States
Santiago
€67
includes taxes & fees
29 Oct - 30 Oct
Quality Inn Cairo I-57
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A bathroom with a sink, mirror, towel rack, shower, and toilet.
A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

5. Eagle Inn Charleston

Eagle Inn Charleston
16.2 km from Fort Defiance State Park
United States
Jackson
€64
includes taxes & fees
29 Sept - 30 Sept
Eagle Inn Charleston
View all properties

Compare popular hotels close to Fort Defiance State Park

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
La Center Motel
7.6
Good
22 reviews
View
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
Super 8 by Wyndham Charleston/Sikeston East MO
6.8
670 reviews
View
A building with a fountain and flower beds in front.
The Riverstone Hotel Charleston-Sikeston
6.8
437 reviews
View
A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57
6.4
295 reviews
View
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
Eagle Inn Charleston
6.6
107 reviews
View

Top Fort Defiance State Park Hotel Reviews

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent
"Everything was great clean helpful Everything friendly."
Kathleen 1-night trip
Posted 13 hours ago
The Riverstone Hotel Charleston-Sikeston
Drury Inn Paducah

Drury Inn Paducah

10/10 Excellent
"*"
Gary 1-night trip
Posted 13 hours ago
Drury Inn Paducah
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

10/10 Excellent
"not full and quiet for a casino environment."
Sophie 1-night trip
Posted 2 days ago
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"perfect"
Sandra D. 5-night trip
Posted 3 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and perfect stay. We have come to consistently appreciate Drury brand for a quality stay. We would definitely recommend this location for clean comfortable accommodations."
Hiram 1-night trip
Posted 5 days ago
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 7 days ago
Days Inn and Suites by Wyndham Sikeston
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 11 days ago
Cozy cabins on beautiful Horseshoe Lake
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

10/10 Excellent
"Great"
Stephanie S. 9-night trip
Posted 12 days ago
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"This is the 2nd time staying here and location is perfect for exploring Cache River. Brent and Wendy are amazing hosts and excellent at communicating. Already booked in November to come back for a week of relaxing with friends and doing some hunting. I highly recommend staying here if you want something clean, good communication and great location."
David P. 3-night trip
Posted 3 weeks ago
Wandering the wineries or hitting the hills? We got you! Come stay!

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

7.4/10 (23 reviews)
You can learn about the history of Columbus when you stop by Columbus-Belmont State Park.
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Ullin City Hall

6.6/10 (4 reviews)
After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums.
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Limekin Springs Trail Trailhead

You can take time to visit Limekin Springs Trail Trailhead during your travels to Ullin. Make some time to visit the shops while you're in the area.
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Front Street Studio & Art Gallery

8.6/10 (15 reviews)
You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savour the top-notch restaurants.
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Lower Cache River Access Area

You can take time to visit Lower Cache River Access Area during your travels to Cypress.
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City of Miner Convention Center

Learn about the events happening in City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savour the top-notch restaurants.
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Henry N Barkhausen Cache River Wetlands Center

8.0/10 (1 review)
You can spend time studying the exhibits at Henry N Barkhausen Cache River Wetlands Center during your travels in Cypress. Amble around the area's parks or experience its museums.
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Frequently asked questions

What's the area like around Fort Defiance State Park?
Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best place to stay close to Fort Defiance State Park?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.
If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If your reservation is non-refundable, you might be able to cancel it and get a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best deals available near Fort Defiance State Park.