Cairo Hotels from €54 - Fully Refundable Options

Our top choices for Cairo hotels

Quality Inn Cairo I-57

Cairo

Maurice

includes taxes & fees

13 Jun - 14 Jun

The Riverstone Hotel Charleston-Sikeston

Charleston

Sherry

includes taxes & fees

24 May - 25 May

Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

Annette

includes taxes & fees

3 Jun - 4 Jun

La Center Motel

La Center

Carrie

includes taxes & fees

23 May - 24 May

Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Charleston

Jackson

includes taxes & fees

2 Jun - 3 Jun

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Stay near popular Cairo attractions

Fort Defiance State Park

3.7/5 (15 reviews)

Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.

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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

2/10 Terrible

"DON'T STAY HERE-- KEEP GOING SOMEWHERE ELSE, & couldn't get a refund--Property is older property being renovated. The workers stay on property. The men congregate outside their rooms drinking, smoking, & some smoking weed. To each his own, but my daughter & I are allergic to cigarette smoke & get headaches really bad. Anything stronger, like weed, gets us to migraine level. It's a "pet friendly" property but NO convenient place for dogs to go out to potty. We were assigned room 116, the very last room far end of the property. No grass anywhere near. We were told to come to the front of the property in front of the office. That's a long walk at 2-3:00 AM to take the dogs out, especially w/men in & out drinking & smoking. We were uneasy w/ that. We asked for a room closer to grass for our dogs but they didn't have any available. The property still is in run down looking stage. Someone's HAIR was still in the shower and their bottle of hair conditioner. The room looked clean but bathroom floor wasn't. The beds were comfortable but weed smells coming from the corridor & outside caused migraines. We had a horrible night's sleep. On top of this terrible experience, a $100 deposit was required. I've stayed at many much nicer places & NEVER had to pay a deposit. We also had to pay per pet fee not one fee for pets per stay. It was awful, no breakfast, packs of jnstant grits and oatmeal, & coffee. We checked in about 9 & left at 5:30 AM. NEVER AGAIN"

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent

"We came to Cape Girardeau for graduation and stayed here for the weekend. The beds were comfy, the outdoor space was lovely and the kitchen was spacious. They have a dart board, plenty of games and movies and have a pool table you can actually use because it’s not crammed in a corner! The hosts are wonderful people who respond quickly. My family all wished we had time to stay another night."

Welcoming 4-bedroom house with AC in charming La Center

10/10 Excellent

"We stayed here while working on a project, and it was honestly one of the best stays I’ve had. The house was super clean, the beds were very comfortable, and the air conditioning worked great. The neighborhood felt safe, the neighbors were friendly, and the location was very convenient with a grocery store just a couple blocks away and a great pizza place nearby.I would definitely stay here again. Highly recommend!"

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent

"This has been one of the best bed and breakfast places I have stayed. The hostess was kind and helpful. There were fresh eggs on the refrigerator and English Muffins in the freezer when we arrived. The fridge had some basics. The dishes and pots and pans were there for basic cooking. There were spices and olive oil spray available. It is a rural location. Wonderful for a peaceful and quiet get away. If you want to ve in the bustle of a city, this is not your place. If you want to wake up to the singing of the birds and beauty of trees and grass, this is a wonderful place to stay. We enjoyed a country stroll down the lane each evening and were greated by the few neighbors as we walked by. It was a wonderful respit from the rush of everyday life. "

More cheap stays in Cairo

La Center Motel

474 W Kentucky Dr La Center KY

€54

23 May - 24 May

includes taxes & fees

7.6/10 Good! (19 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?

Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.

What are some of the best holiday rentals that Cairo has to offer?

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This holiday home rental outside of Cairo is located in a rural location, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in Cairo.

If I need to cancel my hotel reservation in Cairo, will I receive a refund?

Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.

What is staying in Cairo like?

Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 27 hotels and other accommodation options in the surrounding area. Find out more about Cairo.

What should I do while I'm visiting Cairo?

The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.

What's the seasonal weather like in Cairo?

The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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Our top choices for Cairo hotels

Quality Inn Cairo I-57

The Riverstone Hotel Charleston-Sikeston

Super 8 by Wyndham Charleston/Sikeston East MO

La Center Motel

Eagle Inn Charleston

Stay near popular Cairo attractions

Fort Defiance State Park

Learn more about Cairo

Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Wandering the wineries or hitting the hills? We got you! Come stay!

Quality Inn Cairo I-57

Welcoming 4-bedroom house with AC in charming La Center

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

The Riverstone Hotel Charleston-Sikeston

Cozy cabins on beautiful Horseshoe Lake

The Rested Duck Mallard Room

Eagle Inn Charleston

More cheap stays in Cairo

La Center Motel

Super 8 by Wyndham Charleston/Sikeston East MO

The Riverstone Hotel Charleston-Sikeston

Eagle Inn Charleston

Quality Inn Cairo I-57

Frequently asked questions

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