A steel bridge with a sunset in the background.

Cairo Hotels

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Tonight
7 Oct - 8 Oct
Tomorrow
8 Oct - 9 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

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Our top choices for Cairo hotels

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
€68
includes taxes & fees
6 Nov - 7 Nov
Quality Inn Cairo I-57

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
€59
includes taxes & fees
11 Oct - 12 Oct
Super 8 by Wyndham Charleston/Sikeston East MO

3. La Center Motel

La Center Motel
La Center
United States
Carrie
€51
includes taxes & fees
9 Oct - 10 Oct
La Center Motel

4. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
€66
includes taxes & fees
9 Oct - 10 Oct
Eagle Inn Charleston

5. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Kathleen
€66
includes taxes & fees
10 Oct - 11 Oct
The Riverstone Hotel Charleston-Sikeston

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
€258
includes taxes & fees
13 Oct - 14 Oct
Quiet Country Stay: Modern Home Near Paducah
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Stay near popular Cairo attractions

Fort Defiance State Park

7.4/10 (15 reviews)
Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo
A steel bridge with a sunset in the background.

Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

8/10 Good
"The tub in the shower was very slippery. Extremely dangerous for older people like myself"
Alvaro 1-night trip
Posted 15 hours ago
Super 8 by Wyndham Charleston/Sikeston East MO
Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake

8/10 Good
"I booked this cabin for a getaway for two adults and two dogs who don't like other dogs, and it was the perfect location for that. There are no other cabins within sight or within earshot, the road that runs by the cabin is quiet, and there's a park that's similarly very quiet about a 5-minute drive away. Check in was smooth and the cabin is very cute. The facilities, especially the shower, are pretty basic, but everything worked. The cabin is small, but comfortable for two people. There's AC and heating, so the temperature was comfortable.My notes are less a critique of the cabin, and more things to know: The water smells like rotten eggs, to the point where the entire bathroom stank after a shower. My dogs happily drank the tap water, so it seems safe - the area is marshy, so I suspect that explains the smell. If you're sensitive to smells, this might be a challenge. This is woods in the southern Midwest, so mosquitoes were out in force, and my dogs were covered in sticky pricklies the second they left the (nicely!) mowed area of the cabin - again, nothing to do with the cabin, just the reality of the area, and it meant we didn't spend a ton of time outside near the cabin. I might be interested in revisiting during a colder time of year when bugs and plants are dormant. I recommend bringing your own dry firewood because it's humid so any wood at the site might not burn very easily."
Elina S. 2-night trip
Posted 2 days ago
Peaceful secluded cabin located near Horseshoe Lake
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

10/10 Excellent
"nice property would stay there again"
Brian F. 1-night trip
Posted 3 days ago
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"This was one of the most amazing stays at any rental property we have ever had. First let me say the kitchen has every utensil and pot and pan you need. Muffin pans. Baking pans, stainers mugs, plates bowls, cups. Condiments, butter, farm fresh eggs were in the fridge. Snack bars were provided. Charcoal grill was available for use. Everything was clean and orderly. The house has so much heart and soul in it. You can feel the love that has persisted in this house for decades. The yard is shady & spacious for walking your dogs. Jane was a wonderful host and took great care of us. It was a pleasure meeting her. The farm is across from the red house and is home to 20 something horses. It was an all out wonderful and relaxing stay. Don't hesitate to stay with Jane in the redhouse on the farm. It was truly amazing!!"
Chris P. 5-night trip
Posted 7 days ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent
"Super communication! . Accommodating. Nice people"
JASEN 2-night trip
Posted 3 weeks ago
Cozy cabins on beautiful Horseshoe Lake
Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall

10/10 Excellent
"The house was clean & well stocked. Close to town in a quiet neighborhood. Host was responsive. Will stay again if in the area."
Kerry N. 3-night trip
Posted 3 weeks ago
Charming Home just minutes from Interstate and Mall
Wandering the wineries or hitting the hills? We got you! Come stay!

Wandering the wineries or hitting the hills? We got you! Come stay!

10/10 Excellent
"This is the 2nd time staying here and location is perfect for exploring Cache River. Brent and Wendy are amazing hosts and excellent at communicating. Already booked in November to come back for a week of relaxing with friends and doing some hunting. I highly recommend staying here if you want something clean, good communication and great location."
David P. 3-night trip
Posted 1 month ago
Wandering the wineries or hitting the hills? We got you! Come stay!
Quality Inn Cairo I-57

Quality Inn Cairo I-57

8/10 Good
"Good service,nice stuff and no complaints"
Santiago 1-night trip
Posted 1 month ago
Quality Inn Cairo I-57
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

10/10 Excellent
"My bridal party and I stayed here for the days leading up to the wedding, we thought the place was so cute and cozy! You can tell the host takes pride in what they do and wants to make sure their guests are taken care of. The girls appreciated the gas station that’s not even a minute away for their morning snacks and refreshments."
Stephanie H. 3-night trip
Posted 1 month ago
Quiet Country Stay: Modern Home Near Paducah

More cheap stays in Cairo

La Center Motel

La Center Motel

474 W Kentucky Dr La Center KY
€51
9 Oct - 10 Oct
includes taxes & fees
7.6/10 Good! (22 reviews)
La Center Motel
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
€59
11 Oct - 12 Oct
includes taxes & fees
6.8/10 (675 reviews)
Super 8 by Wyndham Charleston/Sikeston East MO
Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
€66
9 Oct - 10 Oct
includes taxes & fees
6.6/10 (107 reviews)
Eagle Inn Charleston
The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO
€66
10 Oct - 11 Oct
includes taxes & fees
The Riverstone Hotel Charleston-Sikeston
Quality Inn Cairo I-57

Quality Inn Cairo I-57

13201 Kessler Road Cairo IL
€68
6 Nov - 7 Nov
includes taxes & fees
6.4/10 (295 reviews)
Quality Inn Cairo I-57

Find out more about Cairo

Top reasons to visit Cairo

  • Scenic Outdoor Adventures: Cairo, Illinois, is a haven for outdoor enthusiasts, offering activities such as camping and exploring picturesque national and state parks.
  • Unique Riverboat Tours: Experience the stunning landscapes along the waterways with a memorable riverboat tour.
  • Rich Historical Significance: Discover the charming streets of Cairo, where history and family-friendly vibes seamlessly blend.
  • Diverse Accommodation Options: Choose from a range of lodgings, including pet-friendly and family-oriented options, ensuring a comfortable stay.
  • Welcoming Local Atmosphere: Engage with the friendly residents and enjoy the unique local culture throughout your visit.

Find great hotels in and around Cairo

Cairo, Illinois offers a delightful selection of accommodations to cater to various preferences, including motels and hotels. Whether you're seeking a pet-friendly retreat, a family-friendly environment, or an LGBTQIA welcoming experience, you'll find options that meet your needs. From charming inns to convenient hotels in the heart of Cairo, your stay promises to be comfortable and enjoyable.

  • Super 8 by Wyndham Charleston/Sikeston East MO: A budget-friendly motel located 16.1km from Cairo, this accommodation is ideal for families seeking a pet-friendly getaway. The hotel features amenities tailored for children, including complimentary cribs upon request. Travellers can enjoy the comfort of their pets with a flexible pet policy that permits certain animals and waives fees for service animals. Its welcoming atmosphere and family-oriented services make it a solid choice for those looking to blend adventure and relaxation.
  • The Riverstone Hotel Charleston-Sikeston: Situated 19.3km from Cairo, The Riverstone Hotel offers a budget-friendly option for business travellers and pet owners alike. The hotel embraces a professional yet comfortable environment, ensuring guests can attend to work commitments while feeling at home. The pet policy accommodates dogs with specific restrictions, and service animals are welcomed without fees. The setting is designed for convenience, making it a practical choice for those balancing work and leisure during their stay.
  • Quality Inn Cairo I-57: Located conveniently within Cairo, Quality Inn offers a budget-friendly experience that caters to families and pet enthusiasts. The hotel provides essential amenities for children, including complimentary cribs and a first aid kit. Pets are also welcome, with a structured policy that includes cleaning fees and deposits. This accommodation balances comfort and accessibility, making it a sensible option for those wishing to explore the surrounding area while enjoying a family-friendly atmosphere.

Where to stay near Cairo

Cairo, Illinois, offers a unique blend of outdoor adventures and rich history, making it an ideal destination for various travellers. Explore the charming streets of Cairo, where family-friendly vibes meet historical significance. Nearby, you'll find delightful campgrounds perfect for a relaxing getaway. Embrace the local atmosphere, whether it's a serene holiday or engaging with the welcoming residents. With its picturesque scenery and diverse experiences, Cairo promises a memorable vacation for everyone.

  • Wickliffe: Situated a mere 9.7km from Cairo, Wickliffe is a charming city that offers a delightful escape into nature. Visitors are drawn to its picturesque scenery and romantic spots, particularly during the peak seasons of March to April and August. Wickliffe is perfect for outdoor enthusiasts, featuring recreational areas and a golf course that cater to both relaxation and activity. Nearby landmarks such as a stunning lake and a national state park provide ample opportunities for exploration and adventure, making Wickliffe a serene haven for those seeking a tranquil getaway.
  • Mound City: Also located 9.7km from Cairo, Mound City is an adventurous destination that appeals to couples and thrill-seekers alike. With peak visitor numbers in March, July, and October, this city offers a range of outdoor experiences, including scenic parks and challenging golf courses. The surrounding area is rich with natural beauty, featuring lush forests and a lovely lake ideal for picnicking or leisurely strolls. Mound City’s urban parks present further recreational opportunities, ensuring a memorable visit for those looking to blend romance and adventure.
  • Wyatt: Just 11.3km away from Cairo, Wyatt is a family-friendly city that provides a vibrant urban atmosphere alongside ample outdoor activities. This locale sees an influx of visitors during the summer months from June to August, making it an excellent choice for those seeking a lively atmosphere. Wyatt boasts golf courses and a dog park, perfect for a day out with the family, while its urban parks and event conference venues cater to various interests. With its blend of city life and family-oriented attractions, Wyatt is a delightful spot for a fun-filled vacation.

Things to do in Cairo

Shopping

Cairo offers quaint shops along its Main Street, perfect for unique gifts and local crafts. If you're up for a drive, head to the nearby West Park Mall, where you'll find a variety of retail outlets and dining options to enhance your shopping experience.

Recreation

Experience tranquillity at the Cairo Community Wellness Centre, where you can enjoy yoga classes and meditation sessions. For outdoor activities, the nearby Mississippi River offers scenic walking trails, ideal for a leisurely stroll or a peaceful nature escape.

Adventure

Cairo, Illinois, offers thrilling outdoor activities at the nearby Mississippi River, where you can enjoy kayaking or fishing. Explore the scenic trails in the local parks for hiking and wildlife observation, or take a leisurely bike ride along the riverfront to soak in the picturesque views.

Nightlife

Experience the relaxed atmosphere at the Riverfront Grill, where you can enjoy a casual dining experience with views of the Mississippi. For a lively evening, visit the Cairo VFW Post for local music and friendly chatter, immersing yourself in the community vibe.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions in and around Cairo

Cairo, Illinois, is a delightful destination for outdoor enthusiasts and those seeking scenic adventures. Visitors can explore various attractions, including national and state parks, nature reserves, and historic forts. These points of interest provide rich cultural experiences and opportunities to immerse oneself in the beauty of the area, making Cairo an ideal spot for a memorable holiday.

  • Columbus-Belmont State Park: Located 27.4km from Cairo, this park offers stunning outdoor scenery and adventurous activities. Enjoy hiking trails, picnicking spots, and beautiful views of the Mississippi River, making it a great place for nature enthusiasts and those seeking a bit of excitement.
  • Ballard Wildlife Management Area: Just 8.0km away, this wildlife reserve presents a unique opportunity to observe local flora and fauna. With its historical significance, it's an ideal spot for budget-conscious travellers who appreciate nature and want to immerse themselves in the area's rich ecological history.
  • Fort Defiance State Park: Nestled within Cairo, this historic fort offers cultural insights into the region's past. Explore the fortifications and enjoy picturesque views where the Mississippi and Ohio Rivers converge, perfect for history buffs and casual visitors alike.

Best time to go to Cairo

The best time to visit Cairo is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendar iconCalendar Monthtemperature iconTemperaturerain iconPrecipitationmostly cloudy iconCloudinessoccupation rate iconOccupancyprice iconPricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighSlightly High
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighAverage
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Reaching Cairo, Illinois, is accessible via several major airports. Cape Girardeau Municipal Airport (CGI) is approximately 41.8km away, with nearby hotels such as Drury Plaza Hotel Cape Girardeau Conference Center and Courtyard by Marriott Cape Girardeau Downtown, both situated about 9.7km from the airport. Barkley Regional Airport (PAH) in Paducah, KY, is about 37.0km away, offering hotel options like the Courtyard by Marriott Paducah, just 8.0km from the airport. Veterans Airport of Southern Illinois (MWA), located 83.7km from Cairo, features accommodations including Drury Inn & Suites Marion, which is a mere 3.2km from the airport.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best holiday rentals that Cairo has to offer?
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286: This holiday home rental outside of Cairo is located in a rural location, and has a patio, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a fridge, a stovetop and a microwave, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 29 hotels and other accommodation options in the surrounding area. Find out more about Cairo.
What should I do while I'm visiting Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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