Cairo Hotels

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Check prices for these dates

Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Cairo hotels

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Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.
"Break fast was excellent "
United States
Uma
The price is €67
includes taxes & fees
17 Jan - 18 Jan 2026
Quality Inn Cairo I-57
Basic Double Room
La Center Motel

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
Just 15 minutes from Ohio River Valley, this La Centre hotel offers convenient amenities including complimentary WiFi and parking. Easy access to Paducah and Barkley Regional Airport makes exploration effortless.
"Quiet and convenient."
United States
Alma
La Center Motel
Front of property – evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (614)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.
"Staff was great! Room was nice. "
United States
Lana
The price is €59
includes taxes & fees
27 Dec - 28 Dec
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The on-site health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.
"Middle of nowhere hotel was ok"
United States
David
The price is €57
includes taxes & fees
27 Dec - 28 Dec
Eagle Inn Charleston
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is €246
includes taxes & fees
22 Jan - 23 Jan 2026
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Fort Defiance State Park

Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.
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Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artefacts from this once-thriving river port town.

See all hotels in Cairo
Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

10/10 Excellent
"We loved our stay in this country location. It was quiet and peaceful yet close enough to Paducah for shopping and restaurants. The home was spotless, and every amenity was available - basic kitchen supplies (mixer, oil, sugar, spices, and much more), lots of towels and blankets and pillows, wifi and TV, washer and dryer, and more I'm probably not thinking of.It was very cold and snowy during our visit, so we made the home a cozy place to watch movies and relax. We even had our three small dogs with us, and there was lots of yard space to walk them.If you visit here, don't miss the National Quilt Museum. It's not your grandmother's quilt - it's amazing fabric art! Oh, and we found a vegan restaurant we liked: Branch Out.Definitely recommend staying here!!!"
Lynne B. 6-night trip
Posted 3 weeks ago
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

More cheap stays in Cairo

Eagle Inn Charleston

Eagle Inn Charleston

2811 East Marshall Street Charleston MO
The price is €57 per night from 27 Dec to 28 Dec
€57
27 Dec - 28 Dec
includes taxes & fees
6.6/10 (104 reviews)

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveller data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Two other choices for your stay in the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.
What are some of the best holiday rentals that Cairo has to offer?
Quiet Country Stay: Modern Home Near Paducah: This holiday home rental outside of Cairo offers a garden, a selection of games and a BBQ to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a fridge, a stovetop and a microwave. See all vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes, the majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you might be able to cancel it and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer, including the restaurants, entertainment choices and riverfront. This city also attracts tourists with its small-town vibe. There are 25 hotels and other accommodation options in the surrounding area. Find out more about Cairo.
What should I do while I'm visiting Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Take a look at what more there is to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August, with an average temperature of 24°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cairo is 1540 mm.

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