A densely packed urban area with numerous buildings and a prominent tower on a hill.

Guayaquil Hotel Guide. Hotels in Puerto Santa Ana, Guayaquil, Ecuador

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Check prices for these dates

This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Puerto Santa Ana hotels

A modern bar area with a bar counter, seating, and a large window.

1. Wyndham Guayaquil Puerto Santa Ana

Wyndham Guayaquil Puerto Santa Ana
4.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (1,003 reviews)
"Love staying at this hotel!"
United States
Isabel
The price is €100
8 Nov - 9 Nov
Wyndham Guayaquil Puerto Santa Ana
A rooftop pool with a view of the city skyline.

2. Luxury Suites Riverfront GYE

Luxury Suites Riverfront GYE
3.5 star property
Puerto Santa Ana
9.4 out of 10, Exceptional, (111 reviews)
"So clean and very nice people. I really recommend this facility, nice environment. My next trip lm booking in this apartment"
United States
Pedro
The price is €77
24 Oct - 25 Oct
Luxury Suites Riverfront GYE
A rooftop terrace with outdoor seating, a pool, and a city view at sunset.

3. River View suites Puerto Santa Ana gye

River View suites Puerto Santa Ana gye
3.0 star property
Puerto Santa Ana
9.0 out of 10, Wonderful, (66 reviews)
"Nice place to stay!"
United States
Aaliyah
The price is €79
1 Nov - 2 Nov
River View suites Puerto Santa Ana gye
A grand room with ornate chandeliers, a large sofa, a round armchair, and a fireplace.

4. Mansión del Río

Mansión del Río
3.5 star property
Las Peñas, 0.6 km from Puerto Santa Ana
8.8 out of 10, Excellent, (151 reviews)
"The facility is very unique. Staff are very friendly. We have an early flight so did not get a chance to have breakfast."
United States
Shuyi
The price is €59
31 Oct - 1 Nov
Mansión del Río
A bathroom with a bathtub, a stone wall, a window with a view, and a table with chairs.

5. Hotel Río Guayas by Art Hotels Ecuador

Hotel Río Guayas by Art Hotels Ecuador
4.0 star property
Las Peñas, 0.6 km from Puerto Santa Ana
10.0 out of 10, Exceptional, (5 reviews)
"Outstanding staff - great property"
United States
septimiu
The price is €359
21 Oct - 22 Oct
Hotel Río Guayas by Art Hotels Ecuador
An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

6. Hotel Ramada

Hotel Ramada
3.0 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
8.0 out of 10, Very good, (418 reviews)
"👍"
United States
Washington
The price is €57
2 Nov - 3 Nov
Hotel Ramada
An outdoor cafe with tables and chairs, surrounded by trees and buildings.

7. Fortune Hotel

Fortune Hotel
3.0 star property
River City, 1 km from Puerto Santa Ana
7.6 out of 10, Good, (10 reviews)
"Is a great place the only problem is the disco bars outside the hotel "
United States
MARIA
The price is €38
21 Oct - 22 Oct
Fortune Hotel
A buffet setup with various food items, a modern chandelier, and a patterned floor.

8. Ibis Styles El Malecon Guayaquil

Ibis Styles El Malecon Guayaquil
4.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.4 out of 10, Exceptional, (354 reviews)
"Nice restaurant. Great location. Room was a good place to rest."
United States
Hector
The price is €63
25 Oct - 26 Oct
Ibis Styles El Malecon Guayaquil
A breakfast table with various foods and a view of a park through a window.

9. Unipark by Oro Verde Hotels

Unipark by Oro Verde Hotels
4.0 star property
Rocafuerte, 2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,004 reviews)
"Great for a short stay"
United States
Maria
The price is €63
20 Nov - 21 Nov
Unipark by Oro Verde Hotels
An aerial view of a hotel with a swimming pool surrounded by lush greenery and a decorative garden.

10. Grand Hotel Guayaquil, Centro Histórico.

Grand Hotel Guayaquil, Centro Histórico.
4.0 star property
Rocafuerte, 2.2 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Great location, great breakfast buffet, adjacent to Iguana park, not far from airport."
Canada
Victor
The price is €76
25 Oct - 26 Oct
Grand Hotel Guayaquil, Centro Histórico.
A neatly made bed with a heart-shaped arrangement of red roses, a champagne bucket, and two wine glasses on a tray.

11. San Francisco Apart Hotel

San Francisco Apart Hotel
3.0 star property
La Atarazana, 1.4 km from Puerto Santa Ana
6.6 out of 10, (26 reviews)
"Nice place, nice amenities, nice staff, we'll back! "
United States
Giovanny
The price is €32
1 Nov - 2 Nov
San Francisco Apart Hotel
A modern hotel lobby with a reception desk, seating area, and a large decorative plant.

12. Courtyard by Marriott Guayaquil

Courtyard by Marriott Guayaquil
3.5 star property
Kennedy, 2.5 km from Puerto Santa Ana
9.0 out of 10, Wonderful, (1,003 reviews)
"Great locations and wonderful staff.!!"
Canada
Carlos
The price is €80
1 Nov - 2 Nov
Courtyard by Marriott Guayaquil
A modern bar area with a bar counter, stools, and a seating area with a table and chairs.

13. Wyndham Garden Guayaquil

Wyndham Garden Guayaquil
3.5 star property
Simón Bolívar, 2.8 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (1,001 reviews)
"Todo excelente"
United States
Cristhian
The price is €70
8 Nov - 9 Nov
Wyndham Garden Guayaquil
A cocktail on a marble table with a pool in the background.

14. Hotel Patrimonial by Greenfield

Hotel Patrimonial by Greenfield
3.5 star property
Downtown Guayaquil, 1.4 km from Puerto Santa Ana
8.4 out of 10, Very good, (166 reviews)
"Excellent location and close to the airport."
United States
Martin Gerardo
The price is €42
26 Oct - 27 Oct
Hotel Patrimonial by Greenfield
A modern hotel room with a large bed, a sofa, a glass coffee table, and a chair. There is a city view through large windows.

15. Doubletree By Hilton Guayaquil

Doubletree By Hilton Guayaquil
5.0 star property
Downtown Guayaquil, 1.7 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (131 reviews)
"Good staff...great location"
United States
ALBERTO
The price is €87
2 Nov - 3 Nov
Doubletree By Hilton Guayaquil
A spacious indoor area with a central open space surrounded by seating arrangements and a pool.

16. Radisson Hotel Guayaquil

Radisson Hotel Guayaquil
5.0 star property
Kennedy, 2.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (751 reviews)
"Very helpful and accommodating airport shuttle service."
United States
Jerry
The price is €85
25 Oct - 26 Oct
Radisson Hotel Guayaquil
A bedroom with a large bed, a desk, a chair, and a mural on the wall.

17. HOTEL PERLA CENTRAL MALECON

HOTEL PERLA CENTRAL MALECON
2.5 star property
Downtown Guayaquil, 1.3 km from Puerto Santa Ana
7.2 out of 10, Good, (30 reviews)
"Great location and friendly staff. We had a great stay."
Australia
Ashleigh
The price is €28
21 Oct - 22 Oct
HOTEL PERLA CENTRAL MALECON
A room with a hammock, striped sofas, a stone floor, and a ceiling fan.

18. NCG SUITE ATARAZANA

NCG SUITE ATARAZANA
2.0 star property
La Atarazana, 0.8 km from Puerto Santa Ana
The price is €36
21 Oct - 22 Oct
NCG SUITE ATARAZANA
A person in a swimsuit and red hat sitting on a green inflatable ring in a pool.

19. Oro Verde Guayaquil

Oro Verde Guayaquil
5.0 star property
Downtown Guayaquil, 2.1 km from Puerto Santa Ana
9.6 out of 10, Exceptional, (1,003 reviews)
"Easy check in and staff very friendly"
United States
Michael
The price is €86
13 Nov - 14 Nov
Oro Verde Guayaquil
A hotel lobby with a modern design, featuring a reception desk, seating area, and decorative columns.

20. Hotel Palace Guayaquil

Hotel Palace Guayaquil
4.0 star property
Rocafuerte, 1.9 km from Puerto Santa Ana
9.2 out of 10, Wonderful, (961 reviews)
"We have stayed at this hotel several times and it is consistently a good experience. Comfortable bed, good air conditioning, restaurant on site, farmacia nearby. The breakfast buffet is especially good."
United States
Bethany
The price is €58
15 Nov - 16 Nov
Hotel Palace Guayaquil
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Puerto Santa Ana

Find the best Puerto Santa Ana areas for the activities you enjoy most.
A row of colorful colonial buildings with balconies and wooden shutters.

Ecuador

Ecuador might not have many top sights, but C.C. Riocentro Sur and Mall del Sur are two attractions nearby that you can check out.

A colorful outdoor installation with large letters spelling out a word.
Photo by Botak Jon
Open Photo by Botak Jon

Downtown Guayaquil

Travellers come to Downtown Guayaquil for its abundant dining options, and you can see top attractions like Sports Federation of Guayas and Artisan Market while you're in town.

A lizard on a metal fence.

Kennedy

Unique features of Kennedy include the shopping and restaurants. Make a stop by San Marino Mall or World Trade Center while you're exploring the area.

A cityscape with a prominent skyscraper, a river, and a bridge.

Simón Bolívar

When in Simón Bolívar, you can plan a visit to Mall del Sol Shopping Center and San Marino Mall, some noteworthy sights in the nearby area.

A densely packed hillside cityscape with colorful buildings and a prominent tower against a sunset sky.

Urdesa

Urdesa is well liked for its restaurants. If you'd like to do some sightseeing in the greater Guayaquil area, you might plan a trip to San Marino Mall or Alban Borja Commercial Center.

Top Puerto Santa Ana Hotel Reviews

Hilton Colon Guayaquil

Hilton Colon Guayaquil

10/10 Excellent
"La mejor opción todo limpio e impecable"
Hilda Yulianny 1-night trip
Posted 18 hours ago
Hilton Colon Guayaquil

Frequently asked questions

What's it like in Puerto Santa Ana?
Puerto Santa Ana is a welcoming neighbourhood that travellers like for its restaurants and sporting events.
Where is the best hotel for a stay in Puerto Santa Ana?
Based on our traveller data, Wyndham Guayaquil Puerto Santa Ana is one of the top choices for your stay in Puerto Santa Ana. This hotel offers a full-service spa and 2 restaurants. Another good choice for your stay in the area is Luxury Suites Riverfront GYE.
How many hotels should I expect to find in Puerto Santa Ana?
If you're searching for places to stay in Guayaquil, Expedia has something to meet your needs with 88 Puerto Santa Ana hotels and other accommodation options to choose from.
If I need to cancel my hotel reservation in Puerto Santa Ana, will I receive a refund?
Yes, most room reservations are fully refundable provided that you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and be given a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to view the best deals in Puerto Santa Ana.
What is there to do around this Guayaquil neighbourhood?
Emporium by The Point, Santa Ana Garden and Santa Ana Hill are just a few of the places to visit in and around Puerto Santa Ana. While you're out sightseeing, Numa Pompilio Llona Street and El Carmen Hill are a couple of additional sights to visit in Guayaquil.

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