Weslaco Hotel Guide - Knapp Medical Center hotels in Weslaco, United States of America.

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Tonight
16 Dec - 17 Dec
Tomorrow
17 Dec - 18 Dec
This weekend
19 Dec - 21 Dec
Next weekend
26 Dec - 28 Dec

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Our top choices for Knapp Medical Center hotels

In-room safe, desk, iron/ironing board, free cots/infant beds
Holiday Inn Express Hotel & Suites Weslaco by IHG

Holiday Inn Express Hotel & Suites Weslaco by IHG

Holiday Inn Express Hotel & Suites Weslaco by IHG
2.5 star property
2.2 km from Knapp Medical Center
9.0 out of 10, Wonderful, (884)
"It was a nice experience "
United States
Matthew
The price is €76
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn Express Hotel & Suites Weslaco by IHG
Room, Multiple Beds, Non Smoking
Super 8 by Wyndham Weslaco

Super 8 by Wyndham Weslaco

Super 8 by Wyndham Weslaco
2.0 star property
2 km from Knapp Medical Center
8.4 out of 10, Very good, (1004)
"Was a great stay."
United States
Rafael
The price is €74
includes taxes & fees
16 Jan - 17 Jan 2026
Super 8 by Wyndham Weslaco
Lobby
Vali Ho Motel By OYO Weslaco Mercedes

Vali Ho Motel By OYO Weslaco Mercedes

Vali Ho Motel By OYO Weslaco Mercedes
2.0 star property
1 km from Knapp Medical Center
8.2 out of 10, Very good, (160)
"The shower was great. Good water pressure and plenty of heat. It was quiet and comfortable."
United States
captain
The price is €54
includes taxes & fees
18 Dec - 19 Dec
Vali Ho Motel By OYO Weslaco Mercedes
Reception
Weslaco Inn by Capital O Near Mercedes

Weslaco Inn by Capital O Near Mercedes

Weslaco Inn by Capital O Near Mercedes
2.0 star property
1.4 km from Knapp Medical Center
8.2 out of 10, Very good, (576)
"Clean rooms, very nice staff. "
United States
Laura
The price is €68
includes taxes & fees
16 Jan - 17 Jan 2026
Weslaco Inn by Capital O Near Mercedes
Lobby sitting area
Express Inn

Express Inn

Express Inn
2.0 star property
2 km from Knapp Medical Center
6.2 out of 10, (394)
"It was an ok room but the restroom ceiling did had water damages and holes."
United States
Joanna
The price is €61
includes taxes & fees
17 Dec - 18 Dec
Express Inn
Apartment
Apartment With 3 Bedrooms 40 Minutes From South Padre

Apartment With 3 Bedrooms 40 Minutes From South Padre

Apartment With 3 Bedrooms 40 Minutes From South Padre
2.0 star property
2.4 km from Knapp Medical Center
10.0 out of 10, Exceptional, (1)
The price is €112
includes taxes & fees
14 Jan - 15 Jan 2026
Apartment With 3 Bedrooms 40 Minutes From South Padre
Apartment
Beautiful Apartment 9 min to Mercedes Outlets

Beautiful Apartment 9 min to Mercedes Outlets

Beautiful Apartment 9 min to Mercedes Outlets
2.0 star property
2.4 km from Knapp Medical Center
8.0 out of 10, Very good, (1)
"Beds were not comfortable. It would sink in the middle. Other than that, everything else was excellent."
United States
Jorge
The price is €178
includes taxes & fees
25 Dec - 26 Dec
Beautiful Apartment 9 min to Mercedes Outlets
Free daily buffet breakfast
Hampton Inn Weslaco

Hampton Inn Weslaco

Hampton Inn Weslaco
2.5 star property
4.1 km from Knapp Medical Center
9.2 out of 10, Wonderful, (600)
"Always nice to stay when visiting family"
United States
Jorge
The price is €94
includes taxes & fees
16 Jan - 17 Jan 2026
Hampton Inn Weslaco
Terrace/patio
Home2 Suites By Hilton San Juan

Home2 Suites By Hilton San Juan

Home2 Suites By Hilton San Juan
3.0 star property
16.7 km from Knapp Medical Center
9.6 out of 10, Exceptional, (454)
"Great hotel to stay when you’re in the Valley "
United States
Carlos
The price is €79
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites By Hilton San Juan
Lobby
La Quinta Inn & Suites by Wyndham Mercedes Outlet Mall

La Quinta Inn & Suites by Wyndham Mercedes Outlet Mall

La Quinta Inn & Suites by Wyndham Mercedes Outlet Mall
3.0 star property
9.8 km from Knapp Medical Center
9.2 out of 10, Wonderful, (1013)
"It has very good breakfast options and a spacious parking lot. The front desk clerk(evening) was very attractive. We were pleased with the hotel."
United States
Alma
The price is €84
includes taxes & fees
5 Jan - 6 Jan 2026
La Quinta Inn & Suites by Wyndham Mercedes Outlet Mall
Premium bedding, desk, laptop workspace, free WiFi
Texas Inn Donna

Texas Inn Donna

Texas Inn Donna
2.5 star property
6.9 km from Knapp Medical Center
8.8 out of 10, Excellent, (154)
"Clean had all we needed nice place to stay"
United States
Sandy
The price is €65
includes taxes & fees
29 Dec - 30 Dec
Texas Inn Donna
Suite, 2 Queen Beds, Accessible, Non Smoking
Comfort Inn & Suites Donna near I-2

Comfort Inn & Suites Donna near I-2

Comfort Inn & Suites Donna near I-2
2.5 star property
8.7 km from Knapp Medical Center
8.8 out of 10, Excellent, (600)
"We enjoyed our stay"
United States
Gloria
The price is €67
includes taxes & fees
11 Jan - 12 Jan 2026
Comfort Inn & Suites Donna near I-2
Lobby
Best Western Town Center Inn

Best Western Town Center Inn

Best Western Town Center Inn
2.5 star property
3.8 km from Knapp Medical Center
8.6 out of 10, Excellent, (958)
"The staff was great and my stay was very relaxing."
United States
Sheila
The price is €75
includes taxes & fees
16 Jan - 17 Jan 2026
Best Western Town Center Inn
Lobby
Motel 6 Weslaco, TX

Motel 6 Weslaco, TX

Motel 6 Weslaco, TX
2.0 star property
3.3 km from Knapp Medical Center
8.4 out of 10, Very good, (1008)
"Todo excelente "
Mexico
Joel
The price is €61
includes taxes & fees
16 Jan - 17 Jan 2026
Motel 6 Weslaco, TX
Exterior
Victoria Palms Inn & Suites

Victoria Palms Inn & Suites

Victoria Palms Inn & Suites
2.5 star property
5.3 km from Knapp Medical Center
8.4 out of 10, Very good, (1005)
"everything was excellent "
United States
Emma
The price is €65
includes taxes & fees
16 Jan - 17 Jan 2026
Victoria Palms Inn & Suites
Free daily continental breakfast
Quality Inn & Suites at The Outlets Mercedes/Weslaco

Quality Inn & Suites at The Outlets Mercedes/Weslaco

Quality Inn & Suites at The Outlets Mercedes/Weslaco
2.5 star property
8.7 km from Knapp Medical Center
8.2 out of 10, Very good, (1005)
"Good ppace tomstay and great location next to outlets for shopping "
United States
Gustavo
The price is €69
includes taxes & fees
30 Dec - 31 Dec
Quality Inn & Suites at The Outlets Mercedes/Weslaco
Exterior
Rodeway Inn San Juan

Rodeway Inn San Juan

Rodeway Inn San Juan
2.0 star property
18.5 km from Knapp Medical Center
8.2 out of 10, Very good, (674)
"Great welcoming staff."
United States
Violetta
The price is €47
includes taxes & fees
30 Dec - 31 Dec
Rodeway Inn San Juan
Reception
Texas Inn Weslaco

Texas Inn Weslaco

Texas Inn Weslaco
2.0 star property
3.3 km from Knapp Medical Center
7.2 out of 10, Good, (224)
"."
Mexico
EBNHER
Texas Inn Weslaco
Outdoor pool
Texas Inn Alamo

Texas Inn Alamo

Texas Inn Alamo
2.5 star property
15.1 km from Knapp Medical Center
7.4 out of 10, Good, (370)
"Room was roomy and clean staff not too considerate about my room request but i like the rooms "
United States
Marisela
Texas Inn Alamo
Indoor pool, outdoor pool
La Quinta Inn & Suites by Wyndham Alamo - McAllen East

La Quinta Inn & Suites by Wyndham Alamo - McAllen East

La Quinta Inn & Suites by Wyndham Alamo - McAllen East
3.0 star property
15.3 km from Knapp Medical Center
8.4 out of 10, Very good, (1009)
"Convenient location and clean."
United States
Erika
The price is €74
includes taxes & fees
11 Jan - 12 Jan 2026
La Quinta Inn & Suites by Wyndham Alamo - McAllen East
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Knapp Medical Center Hotel Reviews

Motel 6 Pharr, TX

Motel 6 Pharr, TX

10/10 Excellent
"No issues. Best motel 6 I have stayed at in many years of business travel. The staff is absolutely wonderful!!"
John 5-night trip
Posted 2 days ago
Motel 6 Pharr, TX

Hotels near other Knapp Medical Center attractions

A Spicebush Swallowtail in Rio Grande Valley State Park, Texas

Valley Nature Center

4.0/5 (21 reviews)
Enjoy an outing to Valley Nature Center during your stay in Weslaco. Visit the shops in this family-friendly area or simply enjoy its restaurants.
See properties
Awesome scenery!
Photo by Jesús Rangel Mendez
Open Photo by Jesús Rangel Mendez

Estero Llano Grande State Park

4.2/5 (10 reviews)
You can take time to visit Estero Llano Grande State Park during your travels to Weslaco. Visit the shops in this family-friendly area or simply enjoy its restaurants.
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Frequently asked questions

What's the area like around Knapp Medical Center?
Knapp Medical Center is located in a budget-friendly area of Weslaco that travellers like for its cathedral. If you're looking for a convenient place to stay, take a look at the 16 hotels and other accommodation options you'll find within a mile.
What's the best place to stay close to Knapp Medical Center?
Weslaco Inn by Capital O Near Mercedes is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an outdoor pool. It's located just a short 0.9 mi (1.4 km) from Knapp Medical Center. Another good option is Vali Ho Motel By OYO Weslaco Mercedes, located just 0.6 mi (1 km) away.
How many hotels should I expect to find near Knapp Medical Center?
Expedia has 16 hotels and other accommodation options within a mile from Knapp Medical Center.
If I need to cancel the hotel reservation for my stay near Knapp Medical Center, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your arrival date. If your reservation is non-refundable, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review top deals close to Knapp Medical Center.

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