La Mesa Guest Houses

A sunset over a mountainous landscape with scattered clouds.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Next weekend

In two weeks

In one month

In two months

Our top choices for La Mesa guest houses

An outdoor patio with multiple tables and chairs, a covered seating area, and a building with a 'HOTEL' sign.

1. El Primero Hotel

Downtown Chula Vista

Richard

includes taxes & fees

25 Oct - 26 Oct

A garden with a gazebo, pathways, and a mountain in the background.

2. Vineyard Hacienda

Jamul

Michele

includes taxes & fees

19 Oct - 20 Oct

A neatly arranged bedroom with a bed, bedside tables, a coffee maker, and a tray with cups and a teapot.

3. Somerset

Downtown San Diego

Elbon

A house with a stone patio, a small pool, and a pergola with string lights.

4. Secluded Garden Cottage Walk to Shops + 55” TV

University City

noel o.

includes taxes & fees

18 Oct - 19 Oct

5. Modern AC Loft – Private Entry, Free Parking

North Park

Ty S.

includes taxes & fees

3 Nov - 4 Nov

A house with a swimming pool, stone exterior, and outdoor seating area.

6. Cottage On The Greens - Stunning Golf Course Views

Rancho Bernardo

David

includes taxes & fees

16 Oct - 17 Oct

A balcony with a patterned floor, a wicker chair, a potted plant, and a view of the sea.

7. Rockaway North - Family Friendly, Garage Parking & Laundry

Mission Beach

Raeann Z.

includes taxes & fees

28 Oct - 29 Oct

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top La Mesa Hotel Reviews

The Sofia Hotel

10/10 Excellent

"Great stay! We appreciated the cold water dispenser on the floor and fridge and microwave. Room had a modern design and controls for lights etc. It was a very reasonable price during a sale. Property had some older carpet and worn surfaces in common areas."

Ocean Beach Hotel

8/10 Good

"Great beachside stay! Be mindful of the surrounding area having a lot of activity into the late evenings -- you can hear all the fun while you try to sleep. No microwave in the room I stayed at, but there are at least ample restaurant choices within walking distance. Overall happy to stay have stayed there and wouldn't mind returning, but not with little kids (because of the evening noise)."

Find out more about La Mesa