Holiday Rentals in La Mesa

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Our top choices for La Mesa holiday rentals

Holiday Home in La Mesa

Designer Poolside 1Bed1Bth Retreat
8.8 out of 10, Excellent, (6)
"Nice private property. Loved sitting by the pool. Very convenient to get around the area."
United States
Mary Jo F.
The price is €281
includes taxes & fees
24 Dec - 25 Dec
Designer Poolside 1Bed1Bth Retreat
2.0 star property
9.6 out of 10, Exceptional, (15)
"Beautiful location right in the middle of tons of fun places to get to in San Diego. Perfect home for a large group stay with backyard fun, great cooking area, and fun plentiful sleeping arrangements "
United States
Tyler K.
Sunnyside Resort Spa, Beach, Zoo, Arcade
9.0 out of 10, Wonderful, (14)
"We had a great time staying at the Fountain House. Everything was clean and comfortable. The neighborhood was quiet and located ideally for the various places we went while in La Mesa/SD area. The decor was very welcoming and up to date. We loved having our coffee in the front yard, which was refreshing with lots of shade. All details for our stay were clear, and all the things we needed were available (ice, glass ware, cooking utensils etc). We have zero complaints :) Thank you for hosting us."
United States
Chanel M.
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
2.0 star property
4BR/3Bth King Bed, Big Yard, Prime Area, Ranch
9.0 out of 10, Wonderful, (2)
"We love a simple no-nonsense place and this was perfect for us. The host is very responsive and was constantly checking in with us on what else we need to be comfortable to stay here. The area is close a lot of nice restaurants so that was a plus. We would love to stay here next time we visit San Diego."
United States
Darakhshan T.
The price is €254
includes taxes & fees
24 Dec - 25 Dec
An elegant, fully furnished guest house for 2-4 guest in San Diego
2.0 star property
La Mesa New 3BR Oasis with Pool and Games!
The price is €311
includes taxes & fees
6 Jan - 7 Jan 2026
Mediterranean-inspired 1BR Guesthouse - Full Kitchen, Workspace & Garden
10.0 out of 10, Exceptional, (1)
The price is €364
includes taxes & fees
11 Jan - 12 Jan 2026
Spacious 4BR/2BTH King Bed Ranch Style, Prime Area

Condo in Historic Downtown Coronado

Coronado Beach Resort
3.0 star property
9.0 out of 10, Wonderful, (752)
"This stay was one of our best yet! Highly recommend! Friendly staff. Great space"
United States
Sheree
The price is €184
includes taxes & fees
4 Jan - 5 Jan 2026
Coronado Beach Resort

Aparthotel in Downtown San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
8.0 out of 10, Very good, (154)
"Everything was perfect about the room and location. The minor flaw was the stench in the lobby from the downstairs restaurant and bar. I loved staying here. "
United States
Chris
Kasa Gaslamp Quarter San Diego

Aparthotel in Downtown San Diego

Sentral Gaslamp Quarter
4.0 star property
9.2 out of 10, Wonderful, (606)
"Everything was splendid. Very friendly staff as well. "
United States
Irving
The price is €133
includes taxes & fees
6 Jan - 7 Jan 2026
Sentral Gaslamp Quarter
4.5 star property
9.6 out of 10, Exceptional, (107)
"would definitely go back and stay there again "
United States
Kounwick
City24 Hotel Little Italy Mission Hills

Condo in Del Mar

Wave Crest Resort
3.0 star property
9.2 out of 10, Wonderful, (144)
"Great location "
United States
Erin
The price is €231
includes taxes & fees
7 Jan - 8 Jan 2026
Wave Crest Resort
8.8 out of 10, Excellent, (30)
"The house was very clean and the neighborhood is pretty quiet. Great for vacation stay."
United States
AJ M.
The price is €197
includes taxes & fees
20 Jan - 21 Jan 2026
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
10.0 out of 10, Exceptional, (4)
"Adorable, romantic room with lots of character and just a stone's throw from the beach! Comfy bed. Would stay here again."
United States
Alisha H.
The price is €224
includes taxes & fees
24 Dec - 25 Dec
Tuluminati:BohoChic Condo Steps from Ocean and Bay
9.2 out of 10, Wonderful, (56)
"Had a great time in San Diego. Will definitely stay there again!"
United States
Xavier Hicks H.
The price is €288
includes taxes & fees
30 Dec - 31 Dec
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
10.0 out of 10, Exceptional, (1)
"Location, good building, lovely host."
United Kingdom
Clarice P.
The price is €149
includes taxes & fees
4 Jan - 5 Jan 2026
Spacious peacefull studio w/free parking, hot tub, gym. Near Balboa Park.
10.0 out of 10, Exceptional, (2)
"Great stay!"
United States
Shay S.
Chic apartment with AC, pool and fitness room in sunny San Diego
10.0 out of 10, Exceptional, (268)
"We enjoyed our stay. The place was perfect and there was even a dog bed, toys, and a water dish filled with water waiting for us when we got there. Within walking distance to lots of dog friendly restaurants and within a 10-15min drive to all the things we wanted to do in San Diego, including an off leash dog beach. Would stay here again."
United States
Michele S.
The price is €210
includes taxes & fees
18 Jan - 19 Jan 2026
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Aparthotel in Downtown San Diego

Kasa Little Italy San Diego
4.5 star property
9.6 out of 10, Exceptional, (355)
"Loved this place "
Canada
Ally
The price is €304
includes taxes & fees
30 Dec - 31 Dec
Kasa Little Italy San Diego
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top La Mesa Hotel Reviews

Find out more about La Mesa

Everything you need to know about La Mesa holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the La Mesa holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect La Mesa holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

La Mesa holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in La Mesa. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A La Mesa holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of La Mesa holiday rentals we have selected for you start as low as €98 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on La Mesa rentals

At Expedia, we put the best La Mesa holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top La Mesa rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream La Mesa holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around La Mesa. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

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Frequently asked questions

Are there holiday rentals in La Mesa?

Yes, there are holiday rentals in La Mesa close to Computer Museum of America, or you can select a more secluded option if you're looking for a relaxing stay. Visitors like the top-notch restaurants and shops in La Mesa. Leave some time to check out the zoo and entertainment venues during your trip.

What are some of the best holiday rentals that La Mesa has to offer?

Oceanfront Beach, Pool, Hot Tub, Pickleball, Movie Theater, Elevator & Golf Cart: This holiday home rental outside of La Mesa is located on the beach, and has an outdoor pool, a fireplace and a BBQ to put you at ease in your new surroundings. It has 8 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. It offers a balcony, a garden and a selection of games so that you can immerse yourself in your holiday.

How many holiday rentals are there in La Mesa?

With 61 Expedia holiday rentals, you're guaranteed to find just the right place for your La Mesa stay.

What can I see and do in La Mesa?

Explore the area and cultural attractions such as Computer Museum of America, or visit one of the family-friendly sights such as San Diego Zoo. While in the area, you can also visit popular places such as Petco Park and Port of San Diego.

What are holiday rentals like in La Mesa?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in La Mesa. Holiday rentals feature amenities such as WiFi and washers and dryers so your stay will be comfortable. If you're concerned about a sanitised environment, holiday rentals can offer a sense of seclusion away from public hotel lifts and busy concierge desks while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great choice for a small group gathering.