Lake City Hotel Guide - Lake City Medical Center hotels in Lake City, United States of America.

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27 Dec - 28 Dec
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28 Dec - 29 Dec
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2 Jan - 4 Jan
In two weeks
9 Jan - 11 Jan

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Our top choices for Lake City Medical Center hotels

Exterior
Tru by Hilton Lake City

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
0.4 km from Lake City Medical Center
9.2 out of 10, Wonderful, (1002)
"Great place for a restful night when traveling. "
United States
Peggy
The price is €96
includes taxes & fees
4 Jan - 5 Jan 2026
Tru by Hilton Lake City
Lobby
Comfort Suites Lake City

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
0.7 km from Lake City Medical Center
9.6 out of 10, Exceptional, (1001)
"Great staff"
United States
Alison
The price is €102
includes taxes & fees
6 Jan - 7 Jan 2026
Comfort Suites Lake City
Exterior
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
0.4 km from Lake City Medical Center
8.8 out of 10, Excellent, (1019)
"Very clean property and a full hot breakfast buffet! "
United States
Julie
The price is €89
includes taxes & fees
28 Dec - 29 Dec
La Quinta Inn & Suite by Wyndham Lake City
Property amenity
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
0.8 km from Lake City Medical Center
9.6 out of 10, Exceptional, (179)
"Nice place for a weekend trip to the springs close by.Would definitely stay here again."
United States
Mary
The price is €102
includes taxes & fees
18 Jan - 19 Jan 2026
Courtyard By Marriott Lake City
Lobby
Best Western Plus Lake City

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
0.7 km from Lake City Medical Center
9.2 out of 10, Wonderful, (1015)
"Fantastic stay 10/10"
United States
Michael
The price is €79
includes taxes & fees
31 Dec - 1 Jan 2026
Best Western Plus Lake City
Terrace/patio
Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
0.8 km from Lake City Medical Center
9.4 out of 10, Exceptional, (737)
"Th room was spotless and well laid out. Reagan was so friendly and helpful when we checked in at 1am. "
United States
Heather
The price is €117
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites by Hilton Lake City
Lobby
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
0.9 km from Lake City Medical Center
9.4 out of 10, Exceptional, (1003)
"Clean room, staff, everyone super helpful ."
United States
Devang
The price is €110
includes taxes & fees
11 Jan - 12 Jan 2026
Hampton Inn & Suites Lake City
Exterior
Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
0.7 km from Lake City Medical Center
8.6 out of 10, Excellent, (1001)
"Nice hotel but a little pricey "
United States
Hilary
The price is €91
includes taxes & fees
11 Jan - 12 Jan 2026
Holiday Inn & Suites Lake City by IHG
BBQ/picnic Area
Americas Best Value Inn Lake City

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
0.8 km from Lake City Medical Center
8.8 out of 10, Excellent, (1000)
"We had a good stay, the room was clean, check in quick and easy, the bed was comfortable."
United States
Alan
The price is €64
includes taxes & fees
6 Jan - 7 Jan 2026
Americas Best Value Inn Lake City
Lobby
Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
1 km from Lake City Medical Center
9.0 out of 10, Wonderful, (169)
"Very clean, friendly staff, safe and quiet "
United States
Amy
The price is €85
includes taxes & fees
11 Jan - 12 Jan 2026
Fairfield Inn & Suites Lake City
Iron/ironing board, free WiFi, bed sheets
Regal Inn

Regal Inn

Regal Inn
2.5 star property
0.8 km from Lake City Medical Center
8.6 out of 10, Excellent, (544)
"very clean room, A/C and heat work great, good TV, outstanding price, staff very friendly , next door to Waffle House, numerous Restaurants within 2 blocks ( walking ) , will be staying here more when traveling "
United States
Robert
The price is €59
includes taxes & fees
29 Dec - 30 Dec
Regal Inn
Lobby
Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
0.5 km from Lake City Medical Center
8.2 out of 10, Very good, (84)
"Large room, comfortable bed, clean, pet friendly"
United States
D'Ann
The price is €58
includes taxes & fees
31 Dec - 1 Jan 2026
Motel 6 – Lake City, Fl – Medical Center
Pillow-top beds, in-room safe, desk, blackout curtains
Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
0.6 km from Lake City Medical Center
7.6 out of 10, Good, (1003)
"Staff was great"
United States
Thomas
The price is €60
includes taxes & fees
28 Dec - 29 Dec
Days Inn by Wyndham Lake City I-75
Outdoor pool, pool loungers
Quality Inn Lake City

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
0.8 km from Lake City Medical Center
7.8 out of 10, Good, (953)
"very clean room, great staff, we will be staying there again when we come to see our daughter "
United States
Gary
The price is €65
includes taxes & fees
25 Jan - 26 Jan 2026
Quality Inn Lake City
Free WiFi, bed sheets
Gateway Inn

Gateway Inn

Gateway Inn
2.5 star property
0.7 km from Lake City Medical Center
7.8 out of 10, Good, (133)
"Always a pleasure to stay there!"
United States
Teresa
Gateway Inn
Soundproofing, bed sheets
Driftwood Inn

Driftwood Inn

Driftwood Inn
2.0 star property
1.1 km from Lake City Medical Center
7.8 out of 10, Good, (758)
"Clean, quiet, comfortable. Courteous staff. Great location. Would definitely stay here again."
United States
Michelle
Driftwood Inn
Exterior
Econo Lodge Lake City-North

Econo Lodge Lake City-North

Econo Lodge Lake City-North
2.0 star property
0.5 km from Lake City Medical Center
6.8 out of 10, (400)
"Clean rooms, friendly and helpful staff. Good value."
United States
Katharine
The price is €75
includes taxes & fees
30 Dec - 31 Dec
Econo Lodge Lake City-North
Reception
Guest Inn

Guest Inn

Guest Inn
2.0 star property
0.6 km from Lake City Medical Center
6.0 out of 10, (192)
"👍"
United States
Suren
Guest Inn
Lobby
Knights Inn Lake City

Knights Inn Lake City

Knights Inn Lake City
1.5 star property
0.8 km from Lake City Medical Center
5.4 out of 10, (638)
"price and room was ok "
United States
Roscoe
The price is €53
includes taxes & fees
27 Jan - 28 Jan 2026
Knights Inn Lake City
Outdoor pool
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
0.6 km from Lake City Medical Center
5.0 out of 10, (1002)
"The place was dated and not very well maintained most foreign owed hotels are"
United States
Buddy
The price is €55
includes taxes & fees
28 Dec - 29 Dec
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Lake City Medical Center Hotel Reviews

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

10/10 Excellent
"The staff was very helpful and friendly"
James 1-night trip
Posted 4 days ago
Motel 6 – Lake City, Fl – Medical Center

Hotels near other Lake City Medical Center attractions

Aerial photo Waterford Lakes Town Center shopping plaza

Lake City Mall

3.8/5 (124 reviews)
You can do some window-shopping at Lake City Mall during your trip to Lake City. While you're in the area, stroll along the lakeside.
See properties
Columbia County Courthouse in Lake City, Florida, United States.

Columbia County Courthouse

3.5/5 (28 reviews)
Columbia County Courthouse is just one of the places to see in Lake City, so why not enjoy the other things to explore during your travels? While you're in the area, stroll along the lakeside.
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Frequently asked questions

What's the area like around Lake City Medical Center?
Lake City Medical Center is located in Lake City. This family-friendly area is known for its beautiful lakeside setting and array of dining options. If you're looking for a convenient place to stay, take a look at the 24 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Lake City Medical Center?
Adjacent to Lake City Medical Center, La Quinta Inn & Suite by Wyndham Lake City is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. Other good choices close by include Tru by Hilton Lake City and Best Western Plus Lake City.
How many hotels will I be able to find near Lake City Medical Center?
Expedia has 24 hotels and other accommodation options within a mile from Lake City Medical Center.
If I need to cancel the hotel reservation for my stay near Lake City Medical Center, will I receive a refund?
Yes, you'll find most room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Add your dates and click on "Search", then you can filter by "fully refundable" to get the top deals on offer near Lake City Medical Center.
What can I see and do near Lake City Medical Center?
You might spend a leisurely day outdoors at Southside Recreation Complex and Southside Sports Complex. A trip to Lake City Mall and Lake DeSoto Farmers Market might be just the ticket for souvenir shopping. Lake City Columbia County Historical Museum, Regal UA Cinema 90 and Florida Department of Transportation are a few additional nearby sights.