Fort Pierce Hotel Guide. Hotels in Main Street Fort Pierce, Fort Pierce, United States of America

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27 Dec - 28 Dec
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2 Jan - 4 Jan
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9 Jan - 11 Jan

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Our top choices for Main Street Fort Pierce hotels

Marina
The Old Apartment

The Old Apartment

The Old Apartment
4.0 star property
Main Street Fort Pierce
The price is €331
includes taxes & fees
4 Jan - 5 Jan 2026
The Old Apartment
Exterior
At Home Inn

At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1007)
"Staff was very friendly and informative."
United States
Mary
The price is €57
includes taxes & fees
29 Dec - 30 Dec
At Home Inn
Reception
Tru by Hilton Port St. Lucie Tradition

Tru by Hilton Port St. Lucie Tradition

Tru by Hilton Port St. Lucie Tradition
2.5 star property
23.6 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (761)
" I’ve stayed twice and it’s been an excellent experience. Clean facilities and great staff. "
United States
Daniel
The price is €89
includes taxes & fees
4 Jan - 5 Jan 2026
Tru by Hilton Port St. Lucie Tradition
Desk, free WiFi, bed sheets
Home2 Suites by Hilton Stuart

Home2 Suites by Hilton Stuart

Home2 Suites by Hilton Stuart
3.0 star property
25.6 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (608)
"Love staying here. The staff are wonderful, the rooms are clean and the breakfast is decent with lots of options. "
United States
Heather
The price is €124
includes taxes & fees
11 Jan - 12 Jan 2026
Home2 Suites by Hilton Stuart
Outdoor pool, pool umbrellas, pool loungers
The Caribbean Court Boutique Hotel

The Caribbean Court Boutique Hotel

The Caribbean Court Boutique Hotel
3.0 star property
20.6 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (862)
"Quiet, extremely clean, super helpful staff, nice pool, and very comfortable bed. Convenient to have restaurant on property. Great place for a couples getaway. "
United States
Jeffrey
The price is €120
includes taxes & fees
4 Jan - 5 Jan 2026
The Caribbean Court Boutique Hotel
Exterior
Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North

Hampton Inn & Suites Stuart-North
2.5 star property
26.1 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1002)
"Staff warm and friendly and helpful with local spots to visit! "
United States
CHRISTY
The price is €123
includes taxes & fees
1 Jan - 2 Jan 2026
Hampton Inn & Suites Stuart-North
Terrace/patio
Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (166)
"Convenient location and good breakfast "
United States
Bruce
The price is €116
includes taxes & fees
4 Jan - 5 Jan 2026
Home2 Suites by Hilton Ft. Pierce I-95
Property amenity
Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
2.5 star property
7.7 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1004)
"everything was clean and the breakfast was great"
United States
Jim
The price is €92
includes taxes & fees
4 Jan - 5 Jan 2026
Fairfield Inn & Suites by Marriott Fort Pierce
Sun deck
Prestige Hotel Vero Beach

Prestige Hotel Vero Beach

Prestige Hotel Vero Beach
2.0 star property
20.5 km from Main Street Fort Pierce
8.4 out of 10, Very good, (1000)
"Great place"
United States
Rosa
The price is €123
includes taxes & fees
11 Jan - 12 Jan 2026
Prestige Hotel Vero Beach
Breakfast, lunch, dinner served; American cuisine, beach views
Ocean Breeze Inn Vero Beach

Ocean Breeze Inn Vero Beach

Ocean Breeze Inn Vero Beach
3.5 star property
23.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1094)
"The balcony overlooked the ocean and we could hear the surf all night. "
United States
Jack
The price is €137
includes taxes & fees
1 Jan - 2 Jan 2026
Ocean Breeze Inn Vero Beach
Outdoor pool, pool umbrellas, pool loungers
Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa

Costa d'Este Beach Resort and Spa
4.0 star property
23 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1001)
"Great vibe and location"
United States
Stephanie
The price is €275
includes taxes & fees
6 Jan - 7 Jan 2026
Costa d'Este Beach Resort and Spa
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (808)
"The front desk was super friendly and very accommodating. Super fast check in and room was perfect. Thank you "
United States
shelley
The price is €113
includes taxes & fees
28 Dec - 29 Dec
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
BBQ/picnic Area
Seahorse Beach Bungalows

Seahorse Beach Bungalows

Seahorse Beach Bungalows
2.0 star property
4.8 km from Main Street Fort Pierce
8.4 out of 10, Very good, (74)
"Location is prime. Walking distance to the beach. The room has everything you need for a good stay. My husband and I are returning for sure!"
United States
Cibele
The price is €67
includes taxes & fees
29 Dec - 30 Dec
Seahorse Beach Bungalows
On the beach, sun-loungers, beach umbrellas, beach towels
Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa

Hutchinson Shores Resort & Spa
4.0 star property
25.2 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1002)
"I would definitely visit again."
United States
Cassandra
The price is €302
includes taxes & fees
2 Jan - 3 Jan 2026
Hutchinson Shores Resort & Spa
Outdoor spa tub
Hutchinson Island Hotel

Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.4 out of 10, Very good, (1347)
"The room was Excellent staff was very friendly I love the fishing dock the local restaurants service and food was great I'll be visiting there again soon "
United States
Darryl
Hutchinson Island Hotel
Outdoor pool, pool loungers
Hampton Inn Vero Beach

Hampton Inn Vero Beach

Hampton Inn Vero Beach
2.5 star property
28.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1002)
"Great place to stay! Sabrina at check-in was amazing! I would definitely recommend staying here. "
United States
Troy
The price is €90
includes taxes & fees
30 Dec - 31 Dec
Hampton Inn Vero Beach
Bar (on property)
The Lucie

The Lucie

The Lucie
3.0 star property
23.6 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1000)
"Great stay, excellent staff. "
United States
Steve
The price is €197
includes taxes & fees
1 Jan - 2 Jan 2026
The Lucie
Outdoor pool, pool loungers
Best Western Downtown Stuart

Best Western Downtown Stuart

Best Western Downtown Stuart
3.0 star property
29.8 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1002)
"Staff were courteous, room was clean, breakfast was good."
United States
CRAIG
The price is €123
includes taxes & fees
28 Dec - 29 Dec
Best Western Downtown Stuart
BBQ/picnic Area
Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1001)
"Great stay! Very friendly staff "
United States
Giovanni
The price is €121
includes taxes & fees
2 Jan - 3 Jan 2026
Residence Inn by Marriott Port St. Lucie
Free daily on-the-go breakfast
Hotel Flamingo Inn & Suites Vero Beach I-95

Hotel Flamingo Inn & Suites Vero Beach I-95

Hotel Flamingo Inn & Suites Vero Beach I-95
2.5 star property
28.6 km from Main Street Fort Pierce
7.6 out of 10, Good, (1001)
"Clean room convenient decent breakfast "
United States
Andrew
The price is €64
includes taxes & fees
5 Jan - 6 Jan 2026
Hotel Flamingo Inn & Suites Vero Beach I-95
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas for the activities you enjoy most.

Lakewood Park

When in Lakewood Park, you can plan a visit to Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse, some noteworthy sights in the nearby area.

Spanish Lakes Country Club Village

While Spanish Lakes Country Club Village isn't home to many top sights, Lakewood Park Regional Park / Pool and McKee Botanical Garden are some notable places to visit nearby.

Spanish Lakes Fairways

While there might not be top attractions in Spanish Lakes Fairways, you can explore the larger area and discover places like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

Meadowood

While Meadowood isn't home to many top sights, Endless Summer Vineyard & Winery and Lakewood Park Regional Park / Pool are some notable places to visit nearby.

Panther Woods

While Panther Woods may not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Endless Summer Vineyard & Winery and Indrio Road Park / Schoolhouse.

Top Main Street Fort Pierce Hotel Reviews

Tru by Hilton Port St. Lucie Tradition

Tru by Hilton Port St. Lucie Tradition

10/10 Excellent
"Great location, quiet and peaceful and around all of the shops you may need. Clean and nice hotel. Breakfast was ok. "
Thomas 1-night trip
Posted 5 days ago
Tru by Hilton Port St. Lucie Tradition

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighbourhood that travellers like for its waterfront, art and shopping. Make sure that you visit Downtown Fort Pierce and Sunrise Theater as part of your Main Street Fort Pierce travel plans.
How many hotels will I find in Main Street Fort Pierce?
Book one of Expedia's 5 hotels and other accommodation options in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! Most room reservations are fully refundable if cancelled prior to the hotel's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within 24 hours of booking. Add dates, click "Search", then use the "fully refundable" filter to get the best options available in Main Street Fort Pierce.
What is there to do in this Fort Pierce neighbourhood?
For cultural attractions in Main Street Fort Pierce, head to Sunrise Theater, Art Mundo and Official Highwaymen Art Gallery. Downtown Fort Pierce and Fort Pierce City Marina are also a couple of places to visit in the neighbourhood. A few places to visit in the area around Main Street Fort Pierce include Fort Pierce Farmer's Market, Manatee Education and Observation Center and House of Seven Gables. A.E. Backus Museum and Marina at Fort Pierce are also worth a visit when you're out sightseeing in Fort Pierce.