Hotel Guide - Main Street hotels in , United States of America.

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Our top choices for Main Street hotels

The Village Inn Cape Cod

The Village Inn Cape Cod
3.5 star property
14.3 km from Main Street
10.0 out of 10, Exceptional, (223)
"It was so charming, would definitely stay there again! "
United States
Kyle
The price is €180
includes taxes & fees
13 Jan - 14 Jan 2026
The Village Inn Cape Cod

Anchor In Distinctive Waterfront Lodging

Anchor In Distinctive Waterfront Lodging
3.0 star property
9.6 km from Main Street
9.4 out of 10, Exceptional, (1004)
"Staff member Sandy very congenial when we checked in. Laid back atmosphere (early December). Will consider for future Hyannis stay."
United States
Lawrence
The price is €163
includes taxes & fees
13 Jan - 14 Jan 2026
Anchor In Distinctive Waterfront Lodging

InnSeason Resorts Captain's Quarters

InnSeason Resorts Captain's Quarters
3.5 star property
19.4 km from Main Street
9.8 out of 10, Exceptional, (193)
"Best scenery ever !"
United States
Jacqueline
The price is €126
includes taxes & fees
5 Jan - 6 Jan 2026
InnSeason Resorts Captain's Quarters

Uncommoner Hotel by Reverie Boutique Collection

Uncommoner Hotel by Reverie Boutique Collection
3.0 star property
10.9 km from Main Street
9.4 out of 10, Exceptional, (99)
"Hotel was quiet and very clean , pool water was cool"
United States
Robyn
The price is €136
includes taxes & fees
1 Jan - 2 Jan 2026
Uncommoner Hotel by Reverie Boutique Collection

Inn on the Sound

Inn on the Sound
3.5 star property
19.9 km from Main Street
9.8 out of 10, Exceptional, (212)
"Quiet, charming, nice breakfast, right across from beach"
United States
Bruce
The price is €262
includes taxes & fees
1 Jan - 2 Jan 2026
Inn on the Sound

The Escape Inn

The Escape Inn
2.5 star property
16.5 km from Main Street
9.4 out of 10, Exceptional, (661)
"Great place"
United States
Karim
The price is €78
includes taxes & fees
5 Jan - 6 Jan 2026
The Escape Inn

The Cove at Yarmouth by Westgate Resorts

The Cove at Yarmouth by Westgate Resorts
3.0 star property
11.2 km from Main Street
9.2 out of 10, Wonderful, (244)
"The staff are amazing! Love the amenities - the pool, recreation center, activities for the kids such as windchime arts and crafts. The arcade is always a hit. The Loft makes it so easy to not have to stress about a place to go to for dinner. The Cove is a great place for everyone! "
United States
Lauren
The price is €125
includes taxes & fees
13 Jan - 14 Jan 2026
The Cove at Yarmouth by Westgate Resorts

The Palmer House Inn

The Palmer House Inn
3.5 star property
21 km from Main Street
9.6 out of 10, Exceptional, (175)
"Nice place to stay"
United States
Brian
The price is €209
includes taxes & fees
4 Jan - 5 Jan 2026
The Palmer House Inn

Brewster by the Sea Inn

Brewster by the Sea Inn
4.0 star property
26.3 km from Main Street
9.8 out of 10, Exceptional, (171)
"Brewster By the Sea has it all - great location, amazing innkeeper, unbelievable breakfasts, and great rooms with perfect amenities. "
United States
Donna
The price is €296
includes taxes & fees
2 Jan - 3 Jan 2026
Brewster by the Sea Inn

The Club at New Seabury

The Club at New Seabury
3.5 star property
10.3 km from Main Street
9.0 out of 10, Wonderful, (341)
"Very relaxing, loved the different clubs available; beach, pool, tennis, playground for the little ones, bars and food. Some shops were closed due to being off season, but still enjoyed our stay. Looking forward to booking again "
United States
Jose O.
The Club at New Seabury

Falmouth Tides

Falmouth Tides
3.0 star property
20.4 km from Main Street
9.4 out of 10, Exceptional, (698)
"Great stay! Great place! Great view! Great people!"
United States
Brian
Falmouth Tides

Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Fairfield Inn & Suites by Marriott Cape Cod Hyannis
2.5 star property
9.1 km from Main Street
8.8 out of 10, Excellent, (666)
"Excellent staff-clean rooms-great location"
United States
Patrice
The price is €115
includes taxes & fees
28 Jan - 29 Jan 2026
Fairfield Inn & Suites by Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis

Courtyard By Marriott Cape Cod Hyannis
3.0 star property
9.2 km from Main Street
8.8 out of 10, Excellent, (489)
"Parking was free and easy, room was very clean and housekeeping service was top notch. "
United States
Maureen
The price is €128
includes taxes & fees
14 Jan - 15 Jan 2026
Courtyard By Marriott Cape Cod Hyannis

Margaritaville Resort Cape Cod

Margaritaville Resort Cape Cod
4.0 star property
8.7 km from Main Street
8.8 out of 10, Excellent, (424)
"Kids animals show ,clean room ,great staff, food great ,amenities 🙏❤️"
United States
Rosa Xavier
The price is €189
includes taxes & fees
4 Jan - 5 Jan 2026
Margaritaville Resort Cape Cod

Bayside Resort Hotel

Bayside Resort Hotel
3.0 star property
11.2 km from Main Street
8.8 out of 10, Excellent, (1528)
"Room was exceptionally clean, front desk staff was top-notch. My 10-year-old loved the pool and the breakfast."
United States
Michael
Bayside Resort Hotel

Hampton Inn & Suites Cape Cod-West Yarmouth

Hampton Inn & Suites Cape Cod-West Yarmouth
2.5 star property
10.7 km from Main Street
8.8 out of 10, Excellent, (1000)
"Rooms were spotless, staff was wonderful and very accommodating. Amenities were great… coffee, tea and hot chocolate in lobby 24 hours a day. Lobby was decorated for Christmas and the holiday season… made for a very festive stay. Breakfast was awesome too!!!"
United States
Deborah
The price is €110
includes taxes & fees
20 Jan - 21 Jan 2026
Hampton Inn & Suites Cape Cod-West Yarmouth

Mansion House Inn And Spa

Mansion House Inn And Spa
3.5 star property
25.8 km from Main Street
9.4 out of 10, Exceptional, (1000)
"Our second time staying. Friendly staff, perfect location, great views. Highly recommend."
United States
Kurt
The price is €178
includes taxes & fees
4 Jan - 5 Jan 2026
Mansion House Inn And Spa

Doubletree by Hilton Cape Cod - Hyannis

Doubletree by Hilton Cape Cod - Hyannis
4.0 star property
9.8 km from Main Street
8.4 out of 10, Very good, (879)
"Nice room, freindly staff. The downside is the food was pricey. "
United States
Steffanie
The price is €116
includes taxes & fees
25 Jan - 26 Jan 2026
Doubletree by Hilton Cape Cod - Hyannis

The Franklin Hotel Martha's Vineyard

The Franklin Hotel Martha's Vineyard
2.0 star property
27.5 km from Main Street
9.2 out of 10, Wonderful, (169)
"Very nice hotel. Clean and tidy. Highly recommended "
United States
Krzysztof
The Franklin Hotel Martha's Vineyard

An English Garden Bed & Breakfast

An English Garden Bed & Breakfast
3.0 star property
22 km from Main Street
9.0 out of 10, Wonderful, (60)
"A charming hotel a block away from a nice sandy beach, loved a stay there."
United States
Hwamee
The price is €211
includes taxes & fees
13 Jan - 14 Jan 2026
An English Garden Bed & Breakfast
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Main Street Hotel Reviews

Hotels near other Main Street attractions

Frequently asked questions

What's the area like around Main Street?
If you're planning to come to the area to visit Main Street, take some time to see the rest of the sights while you're in town. If you're looking for a convenient place to stay, take a look at the 25 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Main Street?
Long Dell Inn is one of the top choices for your stay based on our traveller data, and this B&B offers free breakfast and free parking. It's located 2.5 mi (4.1 km) from Main Street. Other good choices within 5 miles include Craigville Beach Inn and The Ocean View.
How many hotels will I be able to find near Main Street?
Expedia has 25 hotels and other accommodation options within a mile from Main Street.
If I need to cancel the hotel reservation for my stay near Main Street, will I receive a refund?
Yes! The majority of hotel room reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of booking. Put your dates in and click on "Search", then use the "fully refundable" filter to review the best options available near Main Street.
What can I see and do near Main Street?
Study the collections at Centerville Historical Museum, Cahoon Museum of American Art or Toad Hall Classic Sports Car Museum. You can check out the local talent at Cotuit Center for the Arts, Cape Cod Melody Tent and Barnstable Performing Arts Center. Dip your toes in the water at Craigville Beach, Keyes Beach and Dowses Beach.