Jacksonville Hotel Guide - Mayo Clinic Florida hotels in Jacksonville, United States of America.

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Our top choices for Mayo Clinic Florida hotels

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
3.0 star property
1.1 km from Mayo Clinic Florida
9.4 out of 10, Exceptional, (447)
"Great facility to stay."
United States
Gary
The price is €144
includes taxes & fees
24 Dec - 25 Dec
Residence Inn By Marriott Jacksonville - Mayo Clinic Area

Hilton Jacksonville At Mayo Clinic

Hilton Jacksonville At Mayo Clinic
4.5 star property
0.8 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (68)
"Beautiful hotel. Close to Mayo Clinic."
United States
Patty
The price is €126
includes taxes & fees
30 Dec - 31 Dec
Hilton Jacksonville At Mayo Clinic

TownePlace Suites by Marriott Jacksonville East

TownePlace Suites by Marriott Jacksonville East
3.0 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (548)
"Very good hotel"
United States
Careli
The price is €110
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott Jacksonville East

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
2.5 star property
Golden Glades - The Woods, 3.1 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1002)
"very clean room, great staff, very quiet and a variety of breakfast options."
United States
Joy
The price is €98
includes taxes & fees
28 Dec - 29 Dec
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
2.5 star property
2.7 km from Mayo Clinic Florida
8.6 out of 10, Excellent, (1000)
"Good location for a family vacation "
United States
Angel
The price is €102
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
3.0 star property
0.3 km from Mayo Clinic Florida
8.4 out of 10, Very good, (755)
"Great location "
United States
Josiah Christine
The price is €156
includes taxes & fees
26 Dec - 27 Dec
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

Element Jacksonville Beach

Element Jacksonville Beach
3.0 star property
5.4 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (523)
"The hotel was spotless as usual.The staff was fantastic incredible cleanliness"
United States
Robert
The price is €131
includes taxes & fees
3 Jan - 4 Jan 2026
Element Jacksonville Beach

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Holiday Inn Express & Suites Jacksonville - Town Center by IHG
2.5 star property
Southside, 7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (1002)
"Great staff clean rooms. Excellent stay"
United States
Tina
The price is €124
includes taxes & fees
29 Dec - 30 Dec
Holiday Inn Express & Suites Jacksonville - Town Center by IHG

Salt Air Inn & Suites

Salt Air Inn & Suites
2.5 star property
7.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (409)
"A cute little gem with some of the best hospitality in the area. "
United States
Windy
Salt Air Inn & Suites

Margaritaville Jacksonville Beach

Margaritaville Jacksonville Beach
2.5 star property
5.9 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (3436)
"Great hotel"
United States
Gina
The price is €130
includes taxes & fees
28 Dec - 29 Dec
Margaritaville Jacksonville Beach

Hampton Inn Jacksonville Beach/Oceanfront

Hampton Inn Jacksonville Beach/Oceanfront
3.0 star property
6.3 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (2594)
"We thoroughly enjoyed our stay! "
United States
Diane
The price is €126
includes taxes & fees
30 Dec - 31 Dec
Hampton Inn Jacksonville Beach/Oceanfront

TownePlace Suites by Marriott® Jacksonville Mayport

TownePlace Suites by Marriott® Jacksonville Mayport
3.0 star property
10.8 km from Mayo Clinic Florida
9.8 out of 10, Exceptional, (66)
"This was an awesome place to stay."
United States
Christine
The price is €104
includes taxes & fees
28 Dec - 29 Dec
TownePlace Suites by Marriott® Jacksonville Mayport

Hyatt Place Jacksonville / St. Johns Town Center

Hyatt Place Jacksonville / St. Johns Town Center
3.0 star property
Southside, 8.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1004)
"Quiet, near a lot of restaurants and shopping and all within walking distance. Staff was very friendly."
United States
Amber
The price is €108
includes taxes & fees
22 Dec - 23 Dec
Hyatt Place Jacksonville / St. Johns Town Center

The Hotel Palms

The Hotel Palms
3.5 star property
7.8 km from Mayo Clinic Florida
9.6 out of 10, Exceptional, (291)
"stayed here for an event and it was awesome"
United States
clayton
The price is €164
includes taxes & fees
1 Jan - 2 Jan 2026
The Hotel Palms

Best Western Oceanfront

Best Western Oceanfront
3.0 star property
5.7 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1005)
"Great location, clean, comfortable bed, friendly staff"
United States
Jeff
The price is €118
includes taxes & fees
21 Dec - 22 Dec
Best Western Oceanfront

Sheraton Jacksonville Hotel

Sheraton Jacksonville Hotel
4.0 star property
Deerwood, 9.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1005)
"Great stay and great customer service"
United States
Rebecca
The price is €92
includes taxes & fees
21 Dec - 22 Dec
Sheraton Jacksonville Hotel

Four Points by Sheraton Jacksonville Beachfront

Four Points by Sheraton Jacksonville Beachfront
3.0 star property
5.6 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1000)
"Easy to walk to the beach and local restaurant"
United States
Allen D
The price is €164
includes taxes & fees
11 Jan - 12 Jan 2026
Four Points by Sheraton Jacksonville Beachfront

Holiday Inn Express Jacksonville Beach by IHG

Holiday Inn Express Jacksonville Beach by IHG
3.0 star property
4.6 km from Mayo Clinic Florida
9.2 out of 10, Wonderful, (1002)
"The room was very clean, spacious and there was a good variety offered for breakfast. "
United States
Shelley
The price is €107
includes taxes & fees
1 Jan - 2 Jan 2026
Holiday Inn Express Jacksonville Beach by IHG

Springhill Suites By Marriott Jacksonville Beach Oceanfront

Springhill Suites By Marriott Jacksonville Beach Oceanfront
4.0 star property
5.8 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (619)
"Loved staying here. Great hotel. Very clean. The check-in process was smooth and Jay was awesome. I would recommend!"
United States
Kedric
The price is €156
includes taxes & fees
24 Dec - 25 Dec
Springhill Suites By Marriott Jacksonville Beach Oceanfront

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass

Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
3.0 star property
8.5 km from Mayo Clinic Florida
9.0 out of 10, Wonderful, (1000)
"Friendly staff, easy check-in super clean room and facility. Location is excellent as well."
United States
Anthony
The price is €109
includes taxes & fees
4 Jan - 5 Jan 2026
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Mayo Clinic Florida Hotel Reviews

Hotels near other Mayo Clinic Florida attractions

Frequently asked questions

What's the area like around Mayo Clinic Florida?
Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 45 hotels and other accommodation options you'll find within a mile.
Where is the best place to stay close to Mayo Clinic Florida?
Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Other good choices close by include Hilton Jacksonville At Mayo Clinic and Residence Inn By Marriott Jacksonville - Mayo Clinic Area.
How many hotels are there near Mayo Clinic Florida?
Expedia has 45 hotels and other accommodation options within a mile from Mayo Clinic Florida.
If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.
What can I see and do near Mayo Clinic Florida?
You can enjoy live performances at Players by the Sea and Wilson Center For the Arts. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Cradle Creek Preserve. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.