Mesopotamia Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €185 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Mesopotamia

Marriott Corrientes Hotel

Marriott Corrientes Hotel

4.5 out of 5
Av Costanera Juan Pablo II y Lavalle Corrientes
Fully refundableReserve now, pay when you stay
The price is €114 per night from 10 Jan to 11 Jan
€114
10 Jan - 11 Jan
9.6/10 Exceptional! (9 reviews)
Welcoming and accommodating staff. Good location and views of river. Clean and comfortable rooms. Newly opened hotel, the best in the city. Good breakfast buffet.

Reviewed on 22 Dec 2025

Marriott Corrientes Hotel
O2 Hotel Gualeguaychú

O2 Hotel Gualeguaychú

2.5 out of 5
115 3 de Febrero Gualeguaychú Entre Ríos
Fully refundableReserve now, pay when you stay
The price is €34 per night from 5 Jan to 6 Jan
€34
5 Jan - 6 Jan
7.6/10 Good! (67 reviews)
Hotel is very comfortable and clean. There is no breakfast or hotel parking, and the wifi does not work properly in most floors and rooms. Other than that, the staff is very friendly and nice.

Reviewed on 2 Jan 2025

O2 Hotel Gualeguaychú
Hathor Concordia

Hathor Concordia

3 out of 5
Ruta Nacional 14-km 264.5 Concordia Entre Rios
Fully refundableReserve now, pay when you stay
8.6/10 Excellent! (357 reviews)
The hotel staff is very polite Service: "Friendly and efficient," "helpful," "attentive," "welcoming smile," "professional".

Reviewed on 5 Dec 2025

Get rates
Hathor Concordia
See all 490 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Isla Cambacua Beach

Why not spend a lazy afternoon at Isla Cambacua Beach during your trip to Concepción del Uruguay? Experience the area's art scene and museums.

Isla Cambacua Beach

Frequently asked questions

Can I cancel my flight booking to Mesopotamia due to COVID-19?
If you haven't booked yet, glance over the terms and conditions of the airline you're considering. If you've already reserved your flight to Mesopotamia, make use of our Customer Service Portal. It will help determine which COVID-19 policies apply to your booking and provide advice on the next steps.
What's the best way to find cheap flights to Mesopotamia that have flexible change policies?
Search for your bargain flights to Mesopotamia, then tick the "No change fee" box directly underneath the "Flexible change policies" heading. It's that easy. We know that plans change and flexibility is essential, so you can book with confidence with Expedia.
What are some of the general tips for travellers to Mesopotamia during the COVID-19 outbreak?
If it's your first time travelling during the COVID-19 pandemic, you'll notice a range of new rules and restrictions in place. Take note of these tips and make your escape to Mesopotamia a smooth one:
  • Research if any travel restrictions apply to your destination and origin before booking. Also check if there are any requirements you'll have to follow on arrival, such as health testing.
  • Keep your face mask on even during airport screening. A TSA employee will require you to lower your mask temporarily to verify your identity.
  • Instead of handing a TSA employee your boarding pass, position it directly on the scanner yourself. When that's done, hold it up for inspection.
  • You're permitted to take one container of hand sanitizer up to 12 oz (350 ml) in your hand luggage. This will need to be taken out for screening.
  • Place any personal items (phone, wallet and keys for example) in your carry-on rather than a bin to minimize handling during screening.
  • Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA employee to handle and inspect your belongings.

Which airlines fly to Mesopotamia?
Book your ticket with LATAM Airlines and then start putting together your Mesopotamia travel itinerary. This top airline provides 143 flights each month to Ministro Pistarini Intl. Airport (EZE), a major gateway.
How can I find cheap tickets to Mesopotamia?
One of the easiest ways to snare cheap tickets to Mesopotamia is to be flexible with your dates. Search for your flights, then click "flexible dates" above the results. It will bring up the cheapest prices for nearby days. The lowest price for a flight to Mesopotamia in the last seven days was . Booking ahead will generally help you get an even better deal.
How much is a flight to Mesopotamia?
You could have scored a return ticket to Mesopotamia from anywhere between and in the last seven days. For one-way trips leaving from (), the lowest amount paid during this period was just .
What are the most popular airports to fly into in Mesopotamia?
Book your flight to Ministro Pistarini Intl. Airport (EZE) and sample all that Mesopotamia has to offer. As the region's main entry point, around 850 flights land here each month.
When is the cheapest time to fly to Mesopotamia?
Leave for Mesopotamia early on in the week and you'll usually be rewarded more economical fares. Tuesday is typically the cheapest day to get on a plane, followed closely by Monday. If you'd like to avoid the most expensive flights, keep clear of Saturdays.
How much is a plane ticket to Mesopotamia?
Seats to Mesopotamia ranged from to in the last seven days. Normally, the earlier you make a reservation, the better the deal.
Which airlines with flights to Mesopotamia employ COVID-19 cleanliness policies?
In response to the global COVID-19 pandemic, airlines have adopted new precautionary measures to help their passengers and crew get back in the air. Here are some good examples:
  • Aerolineas Argentinas - this airline is known for conducting passenger temperature checks and cleaning with disinfectant.
  • LATAM Airlines - this airline is known for providing passenger masks and capped capacity flights.
  • American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant.

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.