Mesopotamia Holidays

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to €185 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Mesopotamia

To Spiti tis Sofias

To Spiti tis Sofias

Mesopotamia, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
The price is €67 per night from 1 Sept to 2 Sept
€67
1 Sept - 2 Sept
includes taxes & fees
To Spiti tis Sofias
Limneon Resort & Spa

Limneon Resort & Spa

4 out of 5
4th km National Road Kastoria Athens, Kastoria
Fully refundableReserve now, pay when you stay
The price is €104 per night from 1 Sept to 2 Sept
€104
1 Sept - 2 Sept
includes taxes & fees
9.2/10 Wonderful! (187 reviews)
"Incredibly beautiful property. The view is stunning, the pools are amazing! The rooms were nice and quiet, well sound proofed and the curtains were nice and darkened if you needed to sleep in late. Unfortunately I wasn't able to visit the spa but it looked amazing and I'm sure, like everything else ..."

Reviewed on 29 Jul 2025

Limneon Resort & Spa
Hotel Anastassiou

Hotel Anastassiou

2 out of 5
1st km Highway Kastoria-Athens, Kastoria, Western Macedonia
Fully refundableReserve now, pay when you stay
The price is €52 per night from 18 Aug to 19 Aug
€52
18 Aug - 19 Aug
includes taxes & fees
8/10 Very Good! (67 reviews)
"Nice simple stay."

Reviewed on 13 Mar 2025

Hotel Anastassiou
See all 44 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

What to do in Mesopotamia

Archery Odyssey Traditional Archery Experience

Archery Odyssey Traditional Archery Experience

€60
per adult
Archery Odyssey Traditional Archery Experience
See all activities in Mesopotamia

Frequently asked questions

How much does a Mesopotamia holiday package cost?
Offering excellent value package deals on Expedia, you'll be surprised at how little a holiday to Mesopotamia costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Mesopotamia?
You can typically find lower prices and better availability in January, February and March. Take a look at our cheap Mesopotamia holiday packages and you could get some excellent off-season deals.
How many days is enough for Mesopotamia?
The ideal length of your Mesopotamia holiday depends on what you'd like to do and see. Generally, a handful of days to a week will give you time to go to all the main attractions and discover some hidden spots along the way.
How to find the best Mesopotamia package deals?
Begin your search for a Mesopotamia package deal by entering your preferred trip dates and destination under our "Packages" tab. Then apply a few filters, like "Popular locations" and "Property type," to tailor the results to your exact style. You can also sort by "Package discount" and browse offers that come with huge savings. If you don't find the ideal Mesopotamia package deal straight away, just change your dates and search again. Bear in mind that deals are only available for a limited time, so book early and get your Mesopotamia adventure underway.
Is it cheaper to book a Mesopotamia holiday as a package?
Expedia holiday packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll generally snag a better deal than booking each component separately. And you'll still get the freedom to create a personalised Mesopotamia holiday by choosing your preferred airline, accommodation type and car class.
When to book a holiday package to Mesopotamia?
Secure incredible discounts by booking your flights early with Expedia. If spontaneity is more your style, grab one of our last-minute deals for a spur-of-the-moment Mesopotamia holiday.
How to plan a trip to Mesopotamia?

  1. Choose the best time to travel: Your schedule, preferred season and the type of weather you like can all impact your decision on when to visit Mesopotamia.
  2. Set a budget: Factor in costs like food, flights and transportation when working out how much to set aside for your trip to Mesopotamia. Then, pick a property that works with your budget, whether that's a low-cost option or a deluxe getaway.
  3. Decide your trip length: Think about how much time you'd like to spend exploring Mesopotamia. Plan your days so you can get to all the experiences and attractions you're interested in at a comfortable pace.
  4. Bundle your bookings: With your travel dates in order, you can combine your flights, car rental, hotels and more into a customised Mesopotamia holiday package.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.