Hotel Guide - Mississippi River hotels in , United States of America.

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Mississippi River hotels

River's Edge Motel

River's Edge Motel
2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (363 reviews)
"We were just driving through and needed a place to stay for the night. It was an easy check in and very friendly staff so perfect for us."
United States
Brent
The price is €77
includes taxes & fees
21 Apr - 22 Apr
River's Edge Motel

The Eagles Nest Inn

The Eagles Nest Inn
3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (22 reviews)
"Best place to stay in town!"
United States
Kimberly
The price is €92
includes taxes & fees
22 Apr - 23 Apr
The Eagles Nest Inn

Baymont by Wyndham Hannibal

Baymont by Wyndham Hannibal
2.5 star property
26.3 km from Mississippi River
6.4 out of 10, (760 reviews)
"This was a nice area would like to go back and go through the town and do a river boat cruise "
United States
Samantha
The price is €66
includes taxes & fees
20 Apr - 21 Apr
Baymont by Wyndham Hannibal

Riverside Inn Hannibal

Riverside Inn Hannibal
2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (171 reviews)
"Beautiful view of the Mississippi River "
United States
Philip
The price is €167
includes taxes & fees
20 Apr - 21 Apr
Riverside Inn Hannibal

Best Western On The River

Best Western On The River
2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1,002 reviews)
"Nice friendly staff…Tony was very helpful"
United States
Lissa
The price is €106
includes taxes & fees
21 Apr - 22 Apr
Best Western On The River

Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West
2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1,001 reviews)
"Great choices for a continental breakfast!!"
United States
Jeanne
The price is €126
includes taxes & fees
26 Apr - 27 Apr
Sleep Inn & Suites Hannibal West

Garden House Bed and Breakfast

Garden House Bed and Breakfast
2.0 star property
25.2 km from Mississippi River
8.4 out of 10, Very good, (40 reviews)
"Host was helpful with local suggestions for things to and places to eat, as well as local history etc. Room was clean and comfortable, breakfast delicious and social. Gret spit close to downtown "
United States
Jim
The price is €95
includes taxes & fees
24 Apr - 25 Apr
Garden House Bed and Breakfast

Lighthouse Inn & Suites

Lighthouse Inn & Suites
4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (26 reviews)
"Nice room. Matched the pictures. Exactly what we were looking for."
United States
John
The price is €166
includes taxes & fees
20 Apr - 21 Apr
Lighthouse Inn & Suites

Motel 6 Hannibal, MO

Motel 6 Hannibal, MO
2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1,002 reviews)
"They said they had a pool but it was not working and looked like it was never used and the people who worked or owned it were living down the hall from the pool and had their door open. The hall was dark to the pool and the pool had water in it but it was dirty and the area was run down. Disappointed!!"
United States
Kimberly
The price is €55
includes taxes & fees
22 Apr - 23 Apr
Motel 6 Hannibal, MO

Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal
2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (685 reviews)
"The breakfast buffet was very good. Having the pool, hot tub & exercise room was a plus. Location was convenient. Staff was great. Will definitely stay again when in this area."
United States
Ruby
The price is €94
includes taxes & fees
26 Apr - 27 Apr
Comfort Inn & Suites - Hannibal

Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal
2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (231 reviews)
"Park easy staff ok breakfast good room clean but restroom need upgrade "
United States
John
The price is €63
includes taxes & fees
26 Apr - 27 Apr
Days Inn by Wyndham Hannibal

Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1,001 reviews)
"Property was clean and staff was friendly."
United States
Etta
The price is €65
includes taxes & fees
26 Apr - 27 Apr
Super 8 by Wyndham Hannibal

Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West
2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1,019 reviews)
"Everything was great. Clean hotel and friendly staff. Pool was great. Had to go to front desk for pool towels. "
United States
Lee
The price is €88
includes taxes & fees
27 Apr - 28 Apr
Quality Inn & Suites Hannibal West

Howard Johnson BY Wyndham Hannibal

Howard Johnson BY Wyndham Hannibal
2.0 star property
26.3 km from Mississippi River
7.4 out of 10, Good, (163 reviews)
"The gentleman at the front desk was extremely nice and did everything to make my stay wonderful. The breakfast was awesome. The pool was sooo nice. The exercise room was great. I cannot say anything bad about this hotel. This was the first time I stayed here and I will be coming back every three months.!"
United States
Shawn
The price is €57
includes taxes & fees
26 Apr - 27 Apr
Howard Johnson BY Wyndham Hannibal

Economy Inn Wentzville

Economy Inn Wentzville
2.0 star property
86.8 km from Mississippi River
6.4 out of 10, (529 reviews)
"Great value"
United States
Josh
The price is €68
includes taxes & fees
20 Apr - 21 Apr
Economy Inn Wentzville

Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
98 km from Mississippi River
6.8 out of 10, (1,004 reviews)
"This is our second time and overall it is fine and serves its purpose. Easy access to the highway and still quiet. Bed is ready for an upgrade though."
United States
Dawn
The price is €62
includes taxes & fees
25 Apr - 26 Apr
Relax Inn Saint Charles

LAKEVIEWINN

LAKEVIEWINN
2.5 star property
89.4 km from Mississippi River
5.6 out of 10, (41 reviews)
"The staff was very friendly & accommodating with getting luggage up the steps. The door would stick. We had room service 1 time and then no more and we were there a week. We would pick up our towels. We were only there to sleep, cool off, and shower and it did all that. The beds were comfortable. "
United States
Tracey
The price is €65
includes taxes & fees
3 May - 4 May
LAKEVIEWINN

Baymont by Wyndham Keokuk

Baymont by Wyndham Keokuk
2.5 star property
96.1 km from Mississippi River
6.2 out of 10, (505 reviews)
" Very clean-nice room. Breakfast was just o k. Good location downtown but a little noisy being right on main street. Great place for the price. "
United States
Dan
The price is €63
includes taxes & fees
26 Apr - 27 Apr
Baymont by Wyndham Keokuk

Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
97.1 km from Mississippi River
5.8 out of 10, (530 reviews)
"Where friendly place. Quite and convenient. Ample parking event for bobtail. Parking for a set, too. Be Rookies with great food. Step up italian restaurant. Excellent deserts.or quite very good pizza. All walking distance."
United States
Jack
The price is €73
includes taxes & fees
17 May - 18 May
Sleep Inn Saint Charles North

Extended Stay America Select Suites St Louis Earth City

Extended Stay America Select Suites St Louis Earth City
2.5 star property
107.1 km from Mississippi River
6.6 out of 10, (895 reviews)
"Room was very clean. Wonderful staff, they are very courteous and helpful."
United States
Charles
The price is €70
includes taxes & fees
20 Apr - 21 Apr
Extended Stay America Select Suites St Louis Earth City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels close to Mississippi River

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
Property grounds
River's Edge Motel
2.0 star property
9.0
Wonderful
363 reviews
View
Lunch and dinner served, Italian cuisine
The Eagles Nest Inn
3.0 star property
9.4
Exceptional
22 reviews
View
Indoor pool
Baymont by Wyndham Hannibal
2.5 star property
6.4
760 reviews
View
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal
2.5 star property
9.4
Exceptional
171 reviews
View
Desk, iron/ironing board, WiFi, bed sheets
Best Western On The River
2.5 star property
8.6
Excellent
1,002 reviews
View

Top Mississippi River Hotel Reviews

Hotels near other Mississippi River attractions

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Clayton Plaza Hotel & Extended Stay is one of the top choices for your stay based on our traveller data, and this hotel offers free breakfast and an indoor pool. You'll find it 76 mi (122.3 km) from Mississippi River. Other good options around the area include Hollywood Casino & Hotel St. Louis and Pear Tree Inn St. Louis Near Union Station.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.