Hotels closest to Mississippi River in

A bridge spanning a body of water with a city skyline in the background during sunset.

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Our top choices for Mississippi River hotels

A Sleep Inn & Suites building with a covered entrance, stone facade, and a flag.

A modern lobby with a brown sofa, beige armchairs, a round table, and a floor lamp.

An indoor swimming pool with a lifeguard chair, poolside chairs, and a table with chairs.

A hotel room with a bed, a desk, a chair, a sofa, and a TV mounted on the wall.

1. Sleep Inn & Suites Hannibal West

30.3 km from Mississippi River

Patricia

€122

includes taxes & fees

8 Nov - 9 Nov

A restaurant with a bar area, wooden flooring, checkered tablecloths, and a brick wall.

A staircase with wooden steps and a wooden handrail, leading up a brick wall.

A bedroom with a brick wall, a wooden bed, two bedside tables with lamps, and a ceiling fan.

A row of multi-story buildings with a variety of storefronts, including a coffee shop and a restaurant.

2. The Eagles Nest Inn

14.2 km from Mississippi River

Kimberly

€118

includes taxes & fees

2 Nov - 3 Nov

A gazebo with a table and benches, surrounded by trees and a body of water.

A two-story building with a flat roof and a covered entrance. There are two cars parked in front, and a truck is visible on the left.

A hotel room with a bed, two sofas, a small table, a desk with a chair, a TV, and a potted plant.

A hotel room with a bed, a desk, a chair, a television, a microwave, and a lamp.

3. River's Edge Motel

13.6 km from Mississippi River

Joseph

€84

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a large bed, a separate bathroom with a bathtub, and a desk with a chair.

A multi-level indoor pool area with a clear pool, multiple balconies, and a covered seating area.

A multi-level indoor pool area with a visible water slide, a towel rack, and a notice board.

A spacious hotel lobby with a central wooden table, seating, a treadmill, and a large potted plant.

4. Best Western On The River

25.3 km from Mississippi River

Wei

€113

includes taxes & fees

21 Oct - 22 Oct

An indoor swimming pool with a tiled floor, a rock wall, and a palm tree.

A spacious dining area with wooden flooring and tables, surrounded by glass walls and wooden paneling.

A hotel room with a bed, desk, chair, and a bathroom with a bathtub.

A lobby with leather sofas, a fireplace, a flat-screen TV, and a reception desk.

5. Quality Inn & Suites Hannibal West

30 km from Mississippi River

Gayle

€74

includes taxes & fees

15 Nov - 16 Nov

A room with a beige leather sofa, a wooden coffee table, a floor lamp, and a patterned carpet.

A wooden table with a bottle of champagne, two glasses, and scattered rose petals.

A historic building with a stone facade and multiple windows, featuring a sign about Tom Sawyer's fence.

A compact kitchen with a refrigerator, microwave, and sink.

6. Riverside Inn Hannibal

25.1 km from Mississippi River

Janee

€186

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a large bed, a desk with a computer, a television, and a bathtub.

A hotel room with a sofa, armchair, small table, TV, dresser, and a bathtub.

A multi-story hotel with a covered entrance and a sign indicating it is part of the Oak Hill Inn & Suites.

A hotel room with a bathtub, two yellow armchairs, a desk with a chair, a small table, and a lamp.

7. Oak Hill Inn & Suites

71.8 km from Mississippi River

Regina

€103

includes taxes & fees

19 Oct - 20 Oct

A modern kitchen with wooden cabinets, a granite countertop, a coffee machine, a microwave, a toaster, and a refrigerator.

A compact living space with a kitchenette, a sofa, a patterned armchair, and a television.

A lobby with a reception desk, seating area, and a staircase.

8. Heritage Hotel Quincy

47.8 km from Mississippi River

Amy

€79

includes taxes & fees

19 Oct - 20 Oct

A hotel room with a bed, a sofa, a desk, and a lamp.

A Comfort Inn & Suites hotel with a stone facade, a covered entrance, and a clear blue sky.

An indoor swimming pool with wooden walls, a tiled floor, and a sign indicating no diving is allowed.

A restaurant with multiple tables and chairs, an exit sign, and a counter area.

9. Comfort Inn & Suites - Hannibal

26.2 km from Mississippi River

Jerry

€81

includes taxes & fees

15 Nov - 16 Nov

A spacious lobby with a black leather sofa, a matching armchair, a coffee table, and a chandelier.

A hotel room with two beds, a window with red curtains, an air conditioning unit, and two bedside lamps.

A coffee station with a coffee machine, cups, and a sign that says "RISE & SHINE."

A spacious lobby with a fireplace, leather sofas, a coffee table, and a large window with blinds.

10. Motel 6 Hannibal, MO

26.1 km from Mississippi River

Jared

€60

includes taxes & fees

19 Oct - 20 Oct

A hot tub with a rocky backdrop and a mural.

A cozy log cabin interior with a fireplace, wooden furniture, and a television mounted on the wall.

An outdoor patio area with wooden furniture, string lights, and umbrellas.

A restaurant with wooden walls, a bar area, and multiple seating arrangements.

11. Stoney Creek Inn Quincy

46.5 km from Mississippi River

Kent

€122

includes taxes & fees

25 Oct - 26 Oct

A modern reception area with a marble counter, a wooden panel with a light fixture, a fireplace, and a seating area with a sofa and chairs.

An outdoor patio with tables and chairs, green umbrellas, and string lights.

A hotel room with a sofa, armchair, lamp, and a large mirror.

A Holiday Inn hotel with a modern facade, a covered entrance, and landscaped areas with shrubs.

12. Holiday Inn Quincy East by IHG

46.1 km from Mississippi River

Colleen

€109

includes taxes & fees

15 Nov - 16 Nov

A reception area with a marble counter, a 'Days Inn' sign, and a welcome mat.

A hotel room with a dining area, kitchenette, and a door leading to a hallway.

A hotel with a covered entrance, a parking lot, and a clear sky.

A laundry room with a washing machine, dryer, and a shelf with detergent bottles.

13. Days Inn by Wyndham Hannibal

26.4 km from Mississippi River

Christian

€65

includes taxes & fees

25 Oct - 26 Oct

A hotel room with a bed, a desk with a computer, a TV, and a bathroom with a shower.

A modern kitchen with dark cabinets, a central island with bar stools, and pendant lighting.

A reception area with a reception desk, seating area with chairs, a patterned rug, and a large window with a view of the outside.

A hotel room with a bed, a desk with a chair, a television, and a dining area with chairs.

14. Quality Inn & Suites Quincy - Downtown

47.8 km from Mississippi River

Bryan

€125

includes taxes & fees

25 Oct - 26 Oct

A modern hotel with a flat roof, multiple windows, and a sign indicating it is a Super 8 hotel.

A long hallway with a patterned carpet, wooden paneling on the walls, and a ceiling light.

A modern dining area with round tables and chairs, a flat-screen TV mounted on the wall, and a brick accent wall.

A hotel room with a large bed, a desk with a chair, a window with curtains, and a wall-mounted artwork.

15. Super 8 by Wyndham Hannibal

26.3 km from Mississippi River

Betty

€63

includes taxes & fees

21 Oct - 22 Oct

A spacious lobby with a high ceiling, a dining area, and a seating area with sofas and a coffee table.

A spacious lobby with a blue sofa, round coffee table, and blue chairs. There is a reception desk and a seating area with a high ceiling and large windows.

A hotel room with a bed, a dresser, a nightstand with a lamp, a framed map on the wall, and a carpeted floor.

An indoor swimming pool with clear blue water, a tiled floor, and a ceiling with square vents.

16. Drury Inn & Suites St. Louis St. Peters

95.3 km from Mississippi River

Ashley

€112

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a large bed, two bedside lamps, a modern bathroom, and a vibrant abstract painting on the wall.

A modern living room with a grey sofa, a white armchair, a coffee table, and a patterned rug. There is a kitchen in the background with white cabinets and a black door.

A spacious bathroom with a large bathtub, a walk-in shower, and a vanity with a mirror.

A swimming pool with lounge chairs and a covered seating area.

17. Lighthouse Inn & Suites

25.8 km from Mississippi River

Connie

€173

includes taxes & fees

19 Oct - 20 Oct

A hotel lobby with a dining area, a bar, and a fireplace.

A reception desk with a black countertop, wooden paneling, and a patterned glass partition.

A snack shelf stocked with various chips and snacks, a mini-fridge with beverages, and a small refrigerator with hot food items.

An indoor swimming pool with clear blue water, yellow and white lounge chairs, and a clock on the wall.

18. Fairfield Inn & Suites Quincy

46 km from Mississippi River

Chris

€120

includes taxes & fees

1 Nov - 2 Nov

A large indoor swimming pool with multiple levels of balconies, surrounded by seating areas and potted plants.

A clean, modern reception area with a reception desk, a clock, and a potted plant.

A hotel room with two beds, a desk, a chair, and a telephone.

A modern building with a red awning, a parking lot, and a sign indicating an entrance.

19. Howard Johnson BY Wyndham Hannibal

26.3 km from Mississippi River

Debbie

€60

includes taxes & fees

22 Oct - 23 Oct

A spacious lobby with a high ceiling, a reception desk, seating areas, and a staircase leading to an upper level.

A modern lobby with a reception desk, seating area, and a dining section.

A Holiday Inn Express hotel with a modern design, featuring a covered entrance and multiple windows.

A coffee station with two coffee machines and a variety of coffee pods and cups.

20. Holiday Inn Express & Suites St Peters by IHG

93.3 km from Mississippi River

Serah

€126

includes taxes & fees

25 Oct - 26 Oct

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Compare popular hotels close to Mississippi River

Property	Property class	Guest rating
Sleep Inn & Suites Hannibal West	9.6 Exceptional 1,001 reviews	View
The Eagles Nest Inn	9.6 Exceptional 27 reviews	View
River's Edge Motel	9.0 Wonderful 393 reviews	View
Best Western On The River	8.6 Excellent 1,008 reviews	View
Quality Inn & Suites Hannibal West	8.0 Very good 1,001 reviews	View

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

10/10 Excellent

"Baller spot"

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

10/10 Excellent

"Enjoyed my stay with family at the property. The staff were friendly, helpful and accommodating."

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

8/10 Good

"Pretty cool hotel"

Drury Inn & Suites St. Louis Airport

8/10 Good

"*"

Moonrise Hotel

10/10 Excellent

"Had the Vincent Price suite with a city view. Also loved the rooftop terrace."

Renaissance St. Louis Airport Hotel

10/10 Excellent

"Easy check in"

Forest Park Hotel by MDR

10/10 Excellent

"Great, great, great property. well restored, you know, rung back. You tell us it’s buildings older. Amenities are great. Staff’s great, clean. go above and beyond to try to be helpful as much as they can. I felt safe. Yeah, all around good property"

Hampton Inn St. Charles St. Peters

10/10 Excellent

"Fantastic place to stay! The staff was amazing!"

Live by Loews - St.Louis

10/10 Excellent

"Staff were very helpful and friendly.."

Other attractions near Mississippi River

Mark Twain Cave

8.8/10 (89 reviews)

You can find out about the history of Hannibal with a visit to Mark Twain Cave. While in this trendy area, you can savour the top-notch restaurants.

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Sawyer's Creek Fun Park

7.8/10 (16 reviews)

Explore the great outdoors at Sawyer's Creek Fun Park, a lovely green space in Hannibal. While in this walkable area, you can savour the top-notch restaurants.

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Lovers Leap

8.8/10 (171 reviews)

Find out about the history of Hannibal when you spend time at Lovers Leap. While in this walkable area, you can savour the top-notch restaurants.

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Sodalis Nature Preserve

Explore the great outdoors at Sodalis Nature Preserve, a lovely green space in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Bluff City Theater

7.6/10 (5 reviews)

Get tickets for a show at Bluff City Theater, a theatre with a story to tell in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Planters Barn Theater

8.8/10 (22 reviews)

Get tickets for a show at Planters Barn Theater, a popular theatre in Hannibal. While in this walkable area, you can savour the top-notch restaurants.

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Mark Twain Boyhood Home and Museum

9.0/10 (278 reviews)

Find out about the history of Hannibal with a stop at Mark Twain Boyhood Home and Museum. While in this family-friendly area, you can savour the top-notch restaurants.

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Jim's Journey: The Huck Finn Freedom Center

8.4/10 (33 reviews)

You can browse the exhibits at Jim's Journey: The Huck Finn Freedom Center, a museum with a story of its own, during your holiday in Hannibal. While in this family-friendly area, you can savour the top-notch restaurants.

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Frequently asked questions

What's the area like around Mississippi River?

Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.

What's the best hotel to stay close to Mississippi River?

Hollywood Casino & Hotel St. Louis is one of the top choices for your stay based on our traveller data, and this hotel offers a casino and 7 restaurants. You'll find it 65.7 mi (105.7 km) from Mississippi River. Other good options around the area include Hyatt Regency St. Louis at The Arch and Clayton Plaza Hotel & Extended Stay.

If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?

Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.

Hotel Guide - Mississippi River hotels in , United States of America.

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Treat yourself

Be picky

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Mississippi River hotels

1. Sleep Inn & Suites Hannibal West

2. The Eagles Nest Inn

3. River's Edge Motel

4. Best Western On The River

5. Quality Inn & Suites Hannibal West

6. Riverside Inn Hannibal

7. Oak Hill Inn & Suites

8. Heritage Hotel Quincy

9. Comfort Inn & Suites - Hannibal

10. Motel 6 Hannibal, MO

11. Stoney Creek Inn Quincy

12. Holiday Inn Quincy East by IHG

13. Days Inn by Wyndham Hannibal

14. Quality Inn & Suites Quincy - Downtown

15. Super 8 by Wyndham Hannibal

16. Drury Inn & Suites St. Louis St. Peters

17. Lighthouse Inn & Suites

18. Fairfield Inn & Suites Quincy

19. Howard Johnson BY Wyndham Hannibal

20. Holiday Inn Express & Suites St Peters by IHG

Compare popular hotels close to Mississippi River

Top Mississippi River Hotel Reviews

Drury Plaza Hotel St. Louis at the Arch

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Drury Inn & Suites St. Louis Airport

Moonrise Hotel

Renaissance St. Louis Airport Hotel

Forest Park Hotel by MDR

Hampton Inn St. Charles St. Peters

Live by Loews - St.Louis

Other attractions near Mississippi River

Mark Twain Cave

Sawyer's Creek Fun Park

Lovers Leap

Sodalis Nature Preserve

Bluff City Theater

Planters Barn Theater

Mark Twain Boyhood Home and Museum

Jim's Journey: The Huck Finn Freedom Center

Frequently asked questions