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Hotel Guide - Mississippi River hotels in , United States of America.

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Top Trending Hotels Near Mississippi River

Interior
The Eagles Nest Inn

The Eagles Nest Inn

3.0 star property
14.2 km from Mississippi River
9.4 out of 10, Exceptional, (19)
"The room was great. Large and attractive!! Nice bathroom. Had all the convenience you need from TV to mini frig. "
United States
Judith
The price is €94
includes taxes & fees
3 Dec - 4 Dec
The Eagles Nest Inn
Exterior
Sleep Inn & Suites Hannibal West

Sleep Inn & Suites Hannibal West

2.5 star property
30.3 km from Mississippi River
9.6 out of 10, Exceptional, (1009)
"great stay!"
United States
Guy
The price is €101
includes taxes & fees
2 Jan - 3 Jan 2026
Sleep Inn & Suites Hannibal West
Balcony
River's Edge Motel

River's Edge Motel

2.0 star property
13.6 km from Mississippi River
9.0 out of 10, Wonderful, (354)
"Staff was really nice and helpful."
United States
rhonda
The price is €78
includes taxes & fees
27 Dec - 28 Dec
River's Edge Motel
55-inch TV with cable channels, Netflix, Hulu
Riverside Inn Hannibal

Riverside Inn Hannibal

2.5 star property
25.1 km from Mississippi River
9.4 out of 10, Exceptional, (164)
"Great place to stay!"
United States
Sandy
The price is €167
includes taxes & fees
3 Dec - 4 Dec
Riverside Inn Hannibal
Deluxe Room
Lighthouse Inn & Suites

Lighthouse Inn & Suites

4.0 star property
25.8 km from Mississippi River
8.8 out of 10, Excellent, (23)
"Very nice room, close enough to walk to riverfront attractions. "
United States
Robert
The price is €167
includes taxes & fees
3 Dec - 4 Dec
Lighthouse Inn & Suites
Indoor pool, seasonal outdoor pool, pool umbrellas, pool loungers
Best Western On The River

Best Western On The River

2.5 star property
25.3 km from Mississippi River
8.6 out of 10, Excellent, (1006)
"Walkable to the historic downtown area and great breakfast choices."
United States
Dave
The price is €101
includes taxes & fees
2 Jan - 3 Jan 2026
Best Western On The River
Front of property
Garden House Bed and Breakfast

Garden House Bed and Breakfast

2.0 star property
25.2 km from Mississippi River
8.6 out of 10, Excellent, (35)
"Overall stay was great and the host chris is great aswell nothing bad to say about any aspect of our stay!"
United States
Josh
The price is €76
includes taxes & fees
3 Dec - 4 Dec
Garden House Bed and Breakfast
Classic Room, 2 Queen Beds, Non Smoking
Town & Country Inn and Suites

Town & Country Inn and Suites

2.5 star property
45.2 km from Mississippi River
9.2 out of 10, Wonderful, (890)
"Always a great experience! "
United States
Roy
Town & Country Inn and Suites
Indoor spa tub
Stoney Creek Inn Quincy

Stoney Creek Inn Quincy

2.0 star property
46.5 km from Mississippi River
8.8 out of 10, Excellent, (1010)
"Always love staying here"
United States
Ashlynn
The price is €92
includes taxes & fees
3 Dec - 4 Dec
Stoney Creek Inn Quincy
Family Suite, Multiple Beds
Heritage Hotel Quincy

Heritage Hotel Quincy

2.0 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (265)
"Room was very clean Breakfast was satisfying "
United States
Mark
The price is €84
includes taxes & fees
15 Dec - 16 Dec
Heritage Hotel Quincy
Exterior
Holiday Inn Quincy East by IHG

Holiday Inn Quincy East by IHG

3.0 star property
46.1 km from Mississippi River
8.8 out of 10, Excellent, (601)
"Overall very nice property. "
United States
Jeffrey
The price is €113
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Quincy East by IHG
Iron/ironing board, free cots/infant beds, rollaway beds, free WiFi
Quality Inn & Suites Quincy - Downtown

Quality Inn & Suites Quincy - Downtown

2.5 star property
47.8 km from Mississippi River
8.8 out of 10, Excellent, (446)
"It was in a very quite area and easy to find places to est. able to explore the Mississippi river. "
United States
James
The price is €104
includes taxes & fees
1 Jan - 2 Jan 2026
Quality Inn & Suites Quincy - Downtown
Lobby
Quality Inn & Suites Hannibal West

Quality Inn & Suites Hannibal West

2.5 star property
30 km from Mississippi River
8.0 out of 10, Very good, (1020)
"Nice place to stay- friendly staff, good breakfast options and nice clean room."
United States
Mary Beth
The price is €86
includes taxes & fees
2 Jan - 3 Jan 2026
Quality Inn & Suites Hannibal West
Exterior
WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon

2.5 star property
93.4 km from Mississippi River
10.0 out of 10, Exceptional, (14)
"Very nice:) "
United States
Alicia
The price is €73
includes taxes & fees
8 Dec - 9 Dec
WoodSpring Suites St Peters-OFallon
Indoor pool, pool loungers
Comfort Inn & Suites - Hannibal

Comfort Inn & Suites - Hannibal

2.5 star property
26.2 km from Mississippi River
7.6 out of 10, Good, (658)
"The beds were super comfy"
United States
Jayme
The price is €91
includes taxes & fees
14 Dec - 15 Dec
Comfort Inn & Suites - Hannibal
Bar (on property)
Oak Hill Inn & Suites

Oak Hill Inn & Suites

2.5 star property
71.8 km from Mississippi River
9.2 out of 10, Wonderful, (861)
"Great place to stay when visiting Culver-Stockton college!"
United States
Kevin
The price is €103
includes taxes & fees
3 Dec - 4 Dec
Oak Hill Inn & Suites
Lobby sitting area
Motel 6 Hannibal, MO

Motel 6 Hannibal, MO

2.0 star property
26.1 km from Mississippi River
7.4 out of 10, Good, (1009)
"Very clean rooms and staff is very friendly "
United States
Sherrie
The price is €57
includes taxes & fees
10 Dec - 11 Dec
Motel 6 Hannibal, MO
Room, 2 Queen Beds, Non Smoking
Days Inn by Wyndham Hannibal

Days Inn by Wyndham Hannibal

2.0 star property
26.4 km from Mississippi River
7.4 out of 10, Good, (214)
"Left before breakfast great cup of coffee"
United States
David
The price is €64
includes taxes & fees
17 Dec - 18 Dec
Days Inn by Wyndham Hannibal
Exterior
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
86.2 km from Mississippi River
9.4 out of 10, Exceptional, (829)
"Good all around stay "
United States
Chad
The price is €107
includes taxes & fees
2 Jan - 3 Jan 2026
Holiday Inn Express & Suites Wentzville St Louis West by IHG
Exterior
Super 8 by Wyndham Hannibal

Super 8 by Wyndham Hannibal

2.0 star property
26.3 km from Mississippi River
7.2 out of 10, Good, (1006)
"My stay was excellent staff very friendly and breakfast was always great "
United States
Sherrie
The price is €64
includes taxes & fees
3 Dec - 4 Dec
Super 8 by Wyndham Hannibal
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi River Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Very clean "
Mary 1-night trip
Posted 2 days ago
Pear Tree Inn St. Louis Airport

Hotels near other Mississippi River attractions

Mark Twain Cave

4.4/5 (128 reviews)
Explore the great outdoors at Mark Twain Cave, a lovely green space in Hannibal. While in this trendy area, you can savour the top-notch restaurants.
See properties

Mark Twain Cave and Cameron Cave

4.5/5 (51 reviews)
You can find out about the history of Hannibal with a visit to Mark Twain Cave and Cameron Cave. While in this family-friendly area, you can savour the top-notch restaurants.
See properties

Frequently asked questions

What's the area like around Mississippi River?
Mississippi River is located in an area that travellers like for its baseball games. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.
What's the best hotel to stay close to Mississippi River?
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and a 24-hour fitness centre. You'll find it 81.8 mi (131.6 km) from Mississippi River. Other good options around the area include Forest Park Hotel by MDR and Clayton Plaza Hotel & Extended Stay.
If I need to cancel the hotel reservation for my stay near Mississippi River, will I receive a refund?
Yes! Most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your scheduled arrival. If you have a reservation that's non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to review the best deals near Mississippi River.