
Murphysboro Holidays
Photo by Southernmost Illinois Tourism Bureau
- Plan, book, travel with confidence
Better together
Save up to €185 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top hotels in Murphysboro

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
120 MUDDY MONSTER ROAD, Murphysboro, IL
Fully refundable
The price is €99 per night from 7 Sept to 8 Sept
€99
7 Sept - 8 Sept
includes taxes & fees
9.4/10 Exceptional! (467 reviews)
"Excellent in every area. I will return and recommend."
Reviewed on 15 Aug 2025

The Lab! Come stay in our brand new space.
Murphysboro
The price is €180 per night from 23 Aug to 24 Aug
€180
23 Aug - 24 Aug
includes taxes & fees
9.4/10 Exceptional! (9 reviews)
"Nice place, clean and tidy"
Reviewed on 6 Aug 2025

Drury Inn & Suites Marion
2706 W DeYoung St, Marion, IL
Fully refundableReserve now, pay when you stay
The price is €67 per night from 7 Sept to 8 Sept
€67
7 Sept - 8 Sept
includes taxes & fees
9.2/10 Wonderful! (1,012 reviews)
"10 out of 10. If you have been to a Drury Inn, you know. If you haven't, go to one now and you'll understand!"
Reviewed on 19 Aug 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
More trip options
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.