A calm river with clear water, surrounded by dense trees and rocky banks.

O Brien Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
10 Jul - 12 Jul
Next weekend
17 Jul - 19 Jul

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (682 reviews)
"Cheap and food enough"
United States
william
The price is €55
includes taxes & fees
12 Jul - 13 Jul
Quality Inn White Springs Suwanee
View from property

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
2.0 star property
High Springs
10.0 out of 10, Exceptional, (230 reviews)
"Amazing spot to be out of the world."
United States
Tati
The price is €230
includes taxes & fees
9 Jul - 10 Jul
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (531 reviews)
"Everything was very clean and the staff was very friendly."
United States
Sabdi
The price is €104
includes taxes & fees
21 Jul - 22 Jul
Hampton Inn & Suites Alachua I-75
Down duvets, pillow-top beds, blackout curtains, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (737 reviews)
"The staff are so nice and the food is really good. The rooms are pretty clean and the beds are comfortable. This is a decent place to stay if you're just passing through Lake City."
United States
Delaney
The price is €65
includes taxes & fees
21 Jul - 22 Jul
Super 8 by Wyndham Lake City
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,067 reviews)
"The location was great have many restaurants around, and the staff was very friendly"
United States
Carla
The price is €89
includes taxes & fees
19 Jul - 20 Jul
Best Western Plus Lake City
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,004 reviews)
"Nice and restful place to stay"
United States
Frederick
The price is €62
includes taxes & fees
15 Jul - 16 Jul
Days Inn by Wyndham Lake City I-10
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,011 reviews)
"We spent 3 nights, the hotel is very well located, the room was normal, mattresses were comfortable, enough space in the room, breakfast is ok, but I recommend it."
United States
Edgar
The price is €98
includes taxes & fees
26 Jul - 27 Jul
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Garden view

Vista Verde Farm Retreat

Vista Verde Farm Retreat
2.0 star property
Lake City
9.8 out of 10, Exceptional, (19 reviews)
"Calm peaceful stay, staff was very helpful and attentive. "
United States
Patrick
The price is €186
includes taxes & fees
14 Jul - 15 Jul
Vista Verde Farm Retreat
Premium bedding, desk, blackout curtains, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (631 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is €64
includes taxes & fees
9 Jul - 10 Jul
Palms Garden Inn
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (196 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is €146
includes taxes & fees
14 Jul - 15 Jul
The Blanche
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (273 reviews)
"Had an amazing stay. The hotel was nice and clean and up to date."
United States
Mary Magdalene
The price is €115
includes taxes & fees
26 Jul - 27 Jul
Courtyard By Marriott Lake City
Lobby

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (1,008 reviews)
"It was clean and comfortable bed !"
United States
Glenda
The price is €70
includes taxes & fees
19 Jul - 20 Jul
Quality Inn Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,137 reviews)
"Enjoyed our stay"
United States
Tammie
The price is €93
includes taxes & fees
19 Jul - 20 Jul
La Quinta Inn & Suite by Wyndham Lake City
Suite, Multiple Beds, Accessible, Non Smoking

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,005 reviews)
"Great stay - easy - accommodating - quiet!"
United States
Paula
The price is €97
includes taxes & fees
5 Aug - 6 Aug
Comfort Suites Lake City
BBQ/picnic Area

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,003 reviews)
"We stopped for one night. We have stayed here before when visiting. The staff is always helpful and accommodating ."
United States
William
The price is €60
includes taxes & fees
19 Jul - 20 Jul
Americas Best Value Inn Lake City
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,005 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is €62
includes taxes & fees
12 Jul - 13 Jul
Days Inn by Wyndham Lake City I-75
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (606 reviews)
"Surprisingly well maintained and clean for the price. Lady at the front desk was kind and sweet."
United States
Johnny
The price is €61
includes taxes & fees
9 Jul - 10 Jul
Regal Inn
Lobby sitting area

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (204 reviews)
"Clean room hot water nice upgrades and friendly staff"
United States
Pennee
The price is €65
includes taxes & fees
12 Jul - 13 Jul
Motel 6 – Lake City, Fl – Medical Center
Fountain

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (459 reviews)
"Renovated room- friendly staff - Great Location - Charming Quaint"
United States
ellie
The price is €126
includes taxes & fees
13 Jul - 14 Jul
BlueGem Motel
Free daily buffet breakfast

Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (850 reviews)
"Great stay!"
United States
Wes
The price is €101
includes taxes & fees
19 Jul - 20 Jul
Holiday Inn Express & Suites Live Oak by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10

10/10 Excellent
"Great place to stay"
Serhii 1-night trip
Posted less than an hour ago
Days Inn by Wyndham Lake City I-10

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is €57 per night from 9 Jul to 10 Jul
€57
9 Jul - 10 Jul
includes taxes & fees
5/10 (1,005 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are La Quinta Inn & Suite by Wyndham Lake City and Tru by Hilton Lake City. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Provides buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Little River Spring Cave divers poolside Hideaway are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and First Federal Sportsplex in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia