O Brien Hotels from €58 - Fully Refundable Options

A calm river with clear water, surrounded by dense trees and rocky banks.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in O Brien

Pet friendly

Apartment

Pool

Hot tub

Cottage

Family friendly

Cabin

Waterpark

Condo

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for O Brien hotels

A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

A modern hotel lobby with a central island table, seating area with chairs, a fireplace, and a bar area.

A modern hotel lobby with a fireplace, seating areas, and a bar.

A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

1. Comfort Suites Lake City

Lake City

Carma

€90

includes taxes & fees

21 Oct - 22 Oct

A spacious living area with a grey sofa, a coffee table, and a TV stand.

A hotel room with two beds, a desk, a TV, and a large window with curtains.

A hotel entrance with a covered walkway, palm trees, and a clear sky.

A modern kitchen with light wood cabinets, granite countertops, and stainless steel appliances. There are signs on the wall advertising different coffee brands.

2. Best Western Plus Lake City

Lake City

marta

€80

includes taxes & fees

1 Nov - 2 Nov

A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.

A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.

A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.

A hotel lobby with a view of the street, a reception desk, and a large map on the wall.

3. Americas Best Value Inn Lake City

Lake City

Sara

€67

includes taxes & fees

11 Oct - 12 Oct

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

A modern kitchen area with a coffee station, including a coffee machine, cups, and a toaster.

A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.

A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.

4. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Steven

€99

includes taxes & fees

11 Oct - 12 Oct

A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.

A modern hotel with a flat roof, multiple windows, and a covered entrance.

A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.

An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

5. Tru by Hilton Lake City

Lake City

Carlos

€98

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.

A modern lounge area with a fireplace, comfortable seating, a dining table, and a large window offering a view.

6. Fairfield Inn & Suites Lake City

Lake City

Jordan

€93

includes taxes & fees

18 Oct - 19 Oct

A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.

A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

A hotel room with two beds, a desk, a chair, a TV, and a large window with curtains.

7. Courtyard By Marriott Lake City

Lake City

Angel

€116

includes taxes & fees

14 Oct - 15 Oct

A covered outdoor area with a paved walkway, benches, and potted plants.

A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.

A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.

A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

8. Cindys Motel

Mayo

Diane

€84

includes taxes & fees

11 Oct - 12 Oct

9. Hampton Inn & Suites Lake City

Lake City

James

€105

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.

A reception desk with a Holiday Inn sign, two computer monitors, and a security camera.

A hotel room with two beds, a TV, a desk with a lamp, and a window with blinds.

A hotel lobby with multiple seating areas, a bar, and an elevator.

10. Holiday Inn & Suites Lake City by IHG

Lake City

C.jeffery

€101

includes taxes & fees

12 Oct - 13 Oct

A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.

An aerial view of a hotel with a swimming pool, parking lot, and surrounding greenery.

A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

11. Super 8 by Wyndham Lake City

Lake City

Scott

€61

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.

A reception area with a counter, a coffee machine, and a potted plant.

A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.

A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.

12. Quality Inn Lake City

Lake City

Brianna

€77

includes taxes & fees

2 Nov - 3 Nov

An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.

A modern hotel lobby with a reception desk, seating areas, and a large screen.

A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.

A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

13. Home2 Suites by Hilton Lake City

Lake City

William

€114

includes taxes & fees

18 Oct - 19 Oct

An aerial view of a campground with RVs, a swimming pool, and tennis courts.

A wooden cabin with a porch, a front door, and a small window.

A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

A wooden cabin with a kitchen, a bathroom, and a loft bedroom.

14. Suwannee River Rendezvous

Mayo

Beth

€107

includes taxes & fees

9 Oct - 10 Oct

A kitchen counter with a coffee maker, a 'Welcome' sign, and a vase of flowers.

A covered parking area with a Walmart store in the background.

A modern kitchen with a granite countertop, a built-in stove, and a large window with six panels.

A hotel room with two beds, a TV, a desk, and a lamp.

15. Driftwood Inn

Lake City

Tammy

€54

includes taxes & fees

14 Oct - 15 Oct

A hotel room with two beds, a blue wall, and a window with curtains.

A modern kitchen with a built-in stove, a coffee machine, and a sink. There is a trash can and a potted plant near the sink.

A bathroom with a beige sink, a large mirror, and a white trash bin.

A modern living room with a sofa, armchairs, a coffee table, and a reception desk.

16. Gateway Inn

Lake City

Karen

€47

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio area with wicker chairs, a round table, and a fire pit.

A modern interior with a sofa, round tables, and chairs, a TV mounted on the wall, and a patterned wall.

A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.

A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.

17. TownePlace Suites by Marriott Lake City

Lake City

Jennifer

€119

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a TV, a desk, and a painting of a sunset.

A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.

A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.

A reception area with a wooden counter, a clock, and a computer on a desk.

18. Days Inn by Wyndham Lake City I-75

Lake City

Wilberd

€71

includes taxes & fees

11 Oct - 12 Oct

A reception area with a Baymont Inn & Suites sign, a reception desk, a glass-top table, and a door.

A bridge over a pond with a fountain, surrounded by palm trees and a building with a red roof.

A hotel room with a patterned carpet, a sofa, a TV, a desk, and a bed with a patterned bedspread.

A breakfast bar with a coffee machine, a microwave, and a sign reading "Breakfast Corner." There are several wooden tables and chairs arranged around the bar.

19. Baymont by Wyndham Lake City I-75

Lake City

Steve

€58

includes taxes & fees

11 Oct - 12 Oct

A modern kitchen with a large window, a flat-screen TV, and a coffee machine.

A hotel with a swimming pool, white lounge chairs, and a fenced area.

A hotel lobby with a dining area, a reception desk, and a view of the outside.

A hotel room with a bed, desk, chair, and sofa.

20. Quality Inn White Springs Suwanee

White Springs

Pennee

€64

includes taxes & fees

8 Nov - 9 Nov

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Comfort Suites Lake City

10/10 Excellent

"Room and staff were excellent. Good experience all around!"

Americas Best Value Inn Lake City

10/10 Excellent

"No comment"

Courtyard By Marriott Lake City

10/10 Excellent

"Very nice place"

Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent

"Angela was wonderful, smooth check in. Room was clean and the bed was so comfortable. All staff was very friendly and helpful. Breakfast was good."

Hampton Inn & Suites Alachua I-75

10/10 Excellent

"Great place"

Baymont by Wyndham Lake City I-75

8/10 Good

"Little worn"

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent

"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL

€58

11 Oct - 12 Oct

includes taxes & fees

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

€77

2 Nov - 3 Nov

includes taxes & fees

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

€80

1 Nov - 2 Nov

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

€90

21 Oct - 22 Oct

includes taxes & fees

9.4/10 Exceptional! (1,001 reviews)

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

€98

18 Oct - 19 Oct

includes taxes & fees

9.2/10 Wonderful! (1,006 reviews)

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL

€105

8 Nov - 9 Nov

includes taxes & fees

8.4/10 Very good! (888 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.

What are some of the best holiday rentals that O Brien has to offer?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. Our travellers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favourite home for rent in O Brien. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What are some accommodation options with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia

Things to do in Gainesville

O Brien Hotels

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. Comfort Suites Lake City

2. Best Western Plus Lake City

3. Americas Best Value Inn Lake City

4. La Quinta Inn & Suite by Wyndham Lake City

5. Tru by Hilton Lake City

6. Fairfield Inn & Suites Lake City

7. Courtyard By Marriott Lake City

8. Cindys Motel

9. Hampton Inn & Suites Lake City

10. Holiday Inn & Suites Lake City by IHG

11. Super 8 by Wyndham Lake City

12. Quality Inn Lake City

13. Home2 Suites by Hilton Lake City

14. Suwannee River Rendezvous

15. Driftwood Inn

16. Gateway Inn

17. TownePlace Suites by Marriott Lake City

18. Days Inn by Wyndham Lake City I-75

19. Baymont by Wyndham Lake City I-75

20. Quality Inn White Springs Suwanee

Learn more about O Brien

Top O Brien Hotel Reviews

Comfort Suites Lake City

Americas Best Value Inn Lake City

Courtyard By Marriott Lake City

Holiday Inn Express & Suites Live Oak by IHG

Hampton Inn & Suites Alachua I-75

Baymont by Wyndham Lake City I-75

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Tru by Hilton Lake City

Holiday Inn Express & Suites Live Oak by IHG

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app