O Brien Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
22 Feb - 23 Feb
Tomorrow
23 Feb - 24 Feb
Next weekend
27 Feb - 1 Mar
In two weeks
6 Mar - 8 Mar

Filter by

Guest rating
Guest rating
Star rating

Our top choices for O Brien hotels

Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,007 reviews)
"Staff and hotel were wonderful!"
United States
Sandra
The price is €110
includes taxes & fees
9 Mar - 10 Mar
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Free daily on-the-go breakfast

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,009 reviews)
"Clean and staff was very kind "
United States
Rosemary
The price is €107
includes taxes & fees
1 Mar - 2 Mar
Tru by Hilton Lake City
Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,002 reviews)
"Was quite and clean, a little dated but it was a good place to sleep they are pet friendly "
United States
William
The price is €57
includes taxes & fees
23 Feb - 24 Feb
Days Inn by Wyndham Lake City I-10
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1,083 reviews)
"Excellent place to stay."
United States
Donovan
The price is €100
includes taxes & fees
1 Mar - 2 Mar
La Quinta Inn & Suite by Wyndham Lake City
Studio, 1 King Bed

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.4 out of 10, Good, (584 reviews)
"Clean and nice staff "
United States
apollo
The price is €61
includes taxes & fees
25 Feb - 26 Feb
Palms Garden Inn
Down duvets, pillow-top beds, blackout curtains, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.2 out of 10, Good, (693 reviews)
"Clean room, friendly staff, fantastic food!"
United States
John
The price is €60
includes taxes & fees
23 Feb - 24 Feb
Super 8 by Wyndham Lake City
Outdoor pool, open 9:00 AM to 10:00 PM, pool loungers

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"The room was very clean and comfortable. Excellent breakfast and staff was very friendly and helpful."
United States
Kenneth
The price is €133
includes taxes & fees
23 Feb - 24 Feb
Hampton Inn & Suites Lake City
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.2 out of 10, Wonderful, (171 reviews)
"Excellent Hotel! "
United States
jim
The Blanche
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,042 reviews)
"Great place to stay"
United States
Jack
The price is €79
includes taxes & fees
8 Mar - 9 Mar
Best Western Plus Lake City
Suite, Multiple Beds, Accessible, Non Smoking

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1,002 reviews)
"The staff is great"
United States
Tana
The price is €108
includes taxes & fees
1 Mar - 2 Mar
Comfort Suites Lake City
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (486 reviews)
"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5. Will definitely stay again!"
United States
Libbi
The price is €109
includes taxes & fees
8 Mar - 9 Mar
Hampton Inn & Suites Alachua I-75
Free WiFi, bed sheets

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very good, (109 reviews)
"Dog friendly and price."
United States
John
The price is €58
includes taxes & fees
20 Mar - 21 Mar
Motel 6 – Lake City, Fl – Medical Center
Pillow-top beds, in-room safe, desk, blackout curtains

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,003 reviews)
"The room was clean and comfortable. The parking and surrounding area were good. Staff was friendly. "
United States
Lars
The price is €60
includes taxes & fees
23 Feb - 24 Feb
Days Inn by Wyndham Lake City I-75
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (562 reviews)
"Friendly staff, clean rooms, convenient location"
United States
Keith
The price is €59
includes taxes & fees
23 Feb - 24 Feb
Regal Inn
Lobby

Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
Live Oak
7.2 out of 10, Good, (640 reviews)
"Hotel is an older facility but room was clean and staff were exceptionally friendly and professional."
United States
Wayne
The price is €67
includes taxes & fees
8 Mar - 9 Mar
Quality Inn White Springs Suwanee
Lobby

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,006 reviews)
"Nice quiet and comfortable hotel a little gem."
Canada
Tim
The price is €64
includes taxes & fees
23 Feb - 24 Feb
Americas Best Value Inn Lake City
Fountain

BlueGem Motel

BlueGem Motel
2.0 star property
High Springs
9.2 out of 10, Wonderful, (409 reviews)
"Beautiful room, very clean and the bed was incredibly soft and comfortable to sleep in! "
United States
Julians
The price is €77
includes taxes & fees
24 Feb - 25 Feb
BlueGem Motel
Terrace/patio

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (764 reviews)
"This is an excellent hotel while you roadtrip:)"
United States
Desiree Moreno
The price is €126
includes taxes & fees
1 Mar - 2 Mar
Home2 Suites by Hilton Lake City
Pillow-top beds, desk, iron/ironing board, free WiFi

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very good, (982 reviews)
"Staff were great and room was clean and comfortable "
Canada
Ethan
The price is €81
includes taxes & fees
23 Mar - 24 Mar
Quality Inn Lake City
Outdoor spa tub

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,004 reviews)
"Excelente"
Mexico
Eduardo
The price is €56
includes taxes & fees
23 Feb - 24 Feb
Baymont by Wyndham Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent
"Excellent stay. The staff was so friendly. Rooms clean. Delicious breakfast. "
Shawn 1-night trip
Posted 4 days ago
La Quinta Inn & Suite by Wyndham Lake City

More cheap stays in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
The price is €58 per night from 20 Mar to 21 Mar
€58
20 Mar - 21 Mar
includes taxes & fees
8/10 Very Good! (107 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are La Quinta Inn & Suite by Wyndham Lake City and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What are some of the best holiday rentals that O Brien has to offer?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: This highly rated holiday home rental in O Brien is located on the beach, and has a balcony, a garden and a BBQ to put you at ease in your new surroundings. It has 3 bedrooms, as well as a kitchen with a dishwasher, a fridge and a stovetop, so that you can cook with friends or family. You and your friends and family can relax into your holiday with amenities such as a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
What are some accommodation options with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Offers buffet, an outdoor pool and complimentary high-speed (wired) Internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.
How is it to stay in O Brien?
Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.
What are the top places to visit in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.
What's the seasonal weather in O Brien?
The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.

Explore a world of travel with Expedia