Otay Mesa Holidays

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Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was €1,041, price is now €702 per person
€702
per person
27 Jul - 31 Jul
found 1 day ago
Return flight included
Washington (WAS) to San Diego (SAN)
8.6/10 Excellent! (2,004 reviews)
Nice hotel within walking distance of the pier. They were very accommodating with allowing for a late checkout due to our flight delays.

Reviewed on 7 May 2026

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was €1,258, price is now €933 per person
€933
per person
27 Jul - 31 Jul
found 1 day ago
Return flight included
Washington (WAS) to San Diego (SAN)
9/10 Wonderful! (1,327 reviews)
This was my second stay at a Margaritaville hotel and loved it both times (Nashville & San Diego). The hotel has a resort feel which I love. The staff was friendly, the hotel was clean and the location was amazing. I would highly recommend!

Reviewed on 6 May 2026

The Beau Hotel Gaslamp Quarter San Diego

The Beau Hotel Gaslamp Quarter San Diego

3 out of 5
Downtown San Diego
Price was €1,119, price is now €836 per person
€836
per person
27 Jul - 31 Jul
found 1 day ago
Return flight included
Washington (WAS) to San Diego (SAN)
9/10 Wonderful! (705 reviews)
A gorgeous historical hotel in a fabulous location, however, it was not made obvious that because of that there are no elevators. I came with an ADA person and we were on the top floor of a sold out hotel. Additionally, while there was an AC unit in the room it was very small and never cooled down the entire room. We were lucky to be there when it wasn’t very warm. I can’t imagine staying here during the harsh summer months.

Reviewed on 5 May 2026

Hilton San Diego Gaslamp Quarter

Hilton San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was €1,122, price is now €900 per person
€900
per person
27 Jul - 31 Jul
found 1 day ago
Return flight included
Washington (WAS) to San Diego (SAN)
9/10 Wonderful! (310 reviews)
The staff was very friendly and helpful. The restaurant was great.

Reviewed on 27 Apr 2026

Ancora by AvantStay

Ancora by AvantStay

2 out of 5
Downtown San Diego
Price was €1,015, price is now €832 per person
€832
per person
27 Jul - 31 Jul
found 1 day ago
Return flight included
Washington (WAS) to San Diego (SAN)
10/10 Exceptional! (2 reviews)
I had an issue checking in, it was difficult to get a response quickly. But overall, the apartment is very nice. We had a great stay regardless! The amenities are 5stars!

Reviewed on 27 Apr 2026

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego

Downtown San Diego

4 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
Fully refundableReserve now, pay when you stay
The price is €181 per night from 10 May to 11 May
€181
10 May - 11 May
includes taxes & fees
9/10 Wonderful! (3,642 reviews)
This place was great clean and so welcoming I would stay again

Reviewed on 6 May 2026

Hard Rock Hotel San Diego
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
150 W Broadway San Diego CA
Fully refundableReserve now, pay when you stay
The price is €123 per night from 11 May to 12 May
€123
11 May - 12 May
includes taxes & fees
8.6/10 Excellent! (2,020 reviews)
It was great tobhave oarking nextvto the building. It really is a beautiful building. Lots of history. My room was really small. The shower was excellent. I did not sleep well there.

Reviewed on 7 May 2026

The Sofia Hotel
The DEXTRO Little Italy, BW Premier Collection

The DEXTRO Little Italy, BW Premier Collection

3 out of 5
1617 1st Avenue San Diego CA
Fully refundable
The price is €125 per night from 25 May to 26 May
€125
25 May - 26 May
includes taxes & fees
8.8/10 Excellent! (1,523 reviews)
room was clean bathroom also soaps provided dispensers clean. water temp and pressure was off but not enough to complain (at that time) parking was convent and safe (gated) but very small spaces. breakfast was simple but good. staff was friendly and helpful. was in walking distance (3 blocks) from ...

Reviewed on 5 May 2026

The DEXTRO Little Italy, BW Premier Collection
See all 4,931 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as €702, a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo

San Diego Zoo

4.5/5(47 reviews)

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(17 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

€110
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

€79
per adult
82% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

€79
per adult
92% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.