Otay Mesa Holidays

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The Beau Downtown San Diego Gaslamp Quar

The Beau Downtown San Diego Gaslamp Quar

3 out of 5
Downtown San Diego
Price was €528, price is now €379 per person
€379
per person
20 Nov - 23 Nov
found 1 day ago
Return direct flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
8.8/10 Excellent! (446 reviews)
The property was beautiful and the staff was amazing. It is rather loud in the night, but I was expecting that. It was close enough to walk to Gaslamp Quarter, Seaport Village, and Little Italy. Bus stop was a block away. The restaurant on site was amazing as well.

Reviewed on 13 Oct 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was €1,226, price is now €816 per person
€816
per person
30 Dec - 4 Jan
found 19 hours ago
Return flight included
Washington (IAD) to San Diego (SAN)
9/10 Wonderful! (1,038 reviews)
Everything was FABULOUS. The atmosphere, the Ambiance, the band, the food, the location was all top tier.

Reviewed on 12 Oct 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was €1,069, price is now €720 per person
€720
per person
30 Dec - 4 Jan
found 19 hours ago
Return flight included
Washington (IAD) to San Diego (SAN)
8.4/10 Very Good! (1,567 reviews)
Excellent downtown location. Convenient to The convention center, little Italy and many restaurants.

Reviewed on 13 Oct 2025

Pendry San Diego

Pendry San Diego

5 out of 5
Downtown San Diego
Price was €687, price is now €479 per person
€479
per person
20 Nov - 23 Nov
found 1 day ago
Return direct flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
9.2/10 Wonderful! (1,005 reviews)
Staff was so friendly and welcoming.

Reviewed on 6 Oct 2025

Estancia La Jolla Hotel & Spa

Estancia La Jolla Hotel & Spa

4 out of 5
La Jolla Farms
Price was €788, price is now €566 per person
€566
per person
20 Nov - 23 Nov
found 1 day ago
Return direct flight included
Newark Liberty Intl. Airport (EWR) to San Diego (SAN)
9/10 Wonderful! (275 reviews)
Beautiful, very helpful staff

Reviewed on 13 Oct 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
The price is €177 per night from 20 Oct to 21 Oct
€177
20 Oct - 21 Oct
includes taxes & fees
8.2/10 Very Good! (5,985 reviews)
"It was conveniently located near attractions, the airport and had all I need for my trip."

Reviewed on 9 Oct 2025

Wyndham San Diego Bayside
Hampton Inn & Suites San Diego Seaworld

Hampton Inn & Suites San Diego Seaworld

3 out of 5
3888 Greenwood St, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €121 per night from 23 Oct to 24 Oct
€121
23 Oct - 24 Oct
includes taxes & fees
9/10 Wonderful! (148 reviews)
"Good place to stay for marine graduation"

Reviewed on 12 Oct 2025

Hampton Inn & Suites San Diego Seaworld
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €297 per night from 31 Oct to 1 Nov
€297
31 Oct - 1 Nov
includes taxes & fees
9/10 Wonderful! (2,847 reviews)
"Always great! Room and view were beautiful. Only thing was the hallway had bits of trash throughout."

Reviewed on 12 Oct 2025

Manchester Grand Hyatt San Diego
See all 4,819 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as €379, a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo showing a pond, landscape views and zoo animals

San Diego Zoo

4.5/5(47 reviews)

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay which includes a sandy beach

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(17 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Things to do

Having a taste of Mexico

Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego

€62
per adult
92% of travellers recommend
Intro to Mexico Walking Tour: Tijuana Day Trip from San Diego
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

€115
per adult
Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster
From Tijuana: Valle de Guadalupe Shared Winery Tour

From Tijuana: Valle de Guadalupe Shared Winery Tour

€67
per adult
From Tijuana: Valle de Guadalupe Shared Winery Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.