Otay Mesa Holidays

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Price found within the past 48 hours. Click for updated prices.
The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Price was €638, price is now €548 per person
€548
per person
6 Nov - 8 Nov
found 1 day ago
Return direct flight included
Chicago (MDW) to San Diego (SAN)
8.4/10 Very Good! (1,543 reviews)
I stayed at The Sofia Hotel in downtown San Diego and loved its mix of historic charm and modern comfort. The location is excellent—just steps from the Gaslamp Quarter, the waterfront, and conveniently close to the Santa Fe train station, making travel super easy.

Reviewed on 28 Aug 2025

Shore House at The Del, LXR Hotels & Resorts

Shore House at The Del, LXR Hotels & Resorts

4 out of 5
Historic Downtown Coronado
Price was €1,212, price is now €980 per person
€980
per person
6 Nov - 8 Nov
found 1 day ago
Return direct flight included
Chicago (MDW) to San Diego (SAN)
9.2/10 Wonderful! (99 reviews)
The staff was exceptional, making our stay truly memorable. We eagerly anticipate our return to this wonderful establishment. We express our deepest gratitude to the management and staff for their exceptional kindness and hospitality towards our family. We thoroughly enjoyed our stay and look forward to returning in the future.

Reviewed on 15 Aug 2025

Margaritaville Hotel San Diego Gaslamp Quarter

Margaritaville Hotel San Diego Gaslamp Quarter

4 out of 5
Downtown San Diego
Price was €847, price is now €698 per person
€698
per person
6 Nov - 8 Nov
found 1 day ago
Return direct flight included
Chicago (MDW) to San Diego (SAN)
9/10 Wonderful! (993 reviews)
You get wristbands for your hotel keys

Reviewed on 28 Aug 2025

The Wayfarer San Diego

The Wayfarer San Diego

4 out of 5
Mission Beach
Price was €812, price is now €699 per person
€699
per person
6 Nov - 8 Nov
found 1 day ago
Return direct flight included
Chicago (MDW) to San Diego (SAN)
9.4/10 Exceptional! (1,579 reviews)
Property was well kept and clean. Pool and hot tub were convenient. Location is awesome.

Reviewed on 28 Aug 2025

Rancho Bernardo Inn

Rancho Bernardo Inn

4 out of 5
Rancho Bernardo
Price was €843, price is now €728 per person
€728
per person
6 Nov - 8 Nov
found 1 day ago
Return direct flight included
Chicago (MDW) to San Diego (SAN)
8.8/10 Excellent! (1,002 reviews)
The landscaping is beautiful

Reviewed on 26 Aug 2025

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
Get rates
Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €173 per night from 2 Sept to 3 Sept
€173
2 Sept - 3 Sept
includes taxes & fees
Wyndham San Diego Bayside
Bay Club Hotel & Marina

Bay Club Hotel & Marina

3.5 out of 5
2131 Shelter Island Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €123 per night from 8 Sept to 9 Sept
€123
8 Sept - 9 Sept
includes taxes & fees
Bay Club Hotel & Marina
See all 4,664 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as €548, a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo showing a pond, landscape views and zoo animals

San Diego Zoo

4.5/5(47 reviews)

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay which includes a sandy beach

Mission Bay

4.5/5(31 reviews)

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

4.5/5(17 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Things to do

Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

€80
per adult
96% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
Sesame Place® San Diego

Sesame Place® San Diego

€57
per traveller
84% of travellers recommend
Sesame Place® San Diego
Kayak on the San Diego Bay

Kayak on the San Diego Bay

€17
per adult
Kayak on the San Diego Bay
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.