Otay Mesa Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €900 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
Downtown San Diego

Downtown San Diego

4 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct San Diego CA
Fully refundable
The price is €144 per night from 5 Jul to 6 Jul
€144
5 Jul - 6 Jul
includes taxes & fees
8.2/10 Very Good! (1,757 reviews)
"Super comfortable and clean. Yummy breakfast. Eggs, two types of sausage, toast, bagels, cereal, oatmeal, pancakes, yogurt, fruit, crab and orange juice, coffee, milk, potatoes"

Reviewed on 21 Jun 2026

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
Fully refundableReserve now, pay when you stay
The price is €319 per night from 25 Jun to 26 Jun
€319
25 Jun - 26 Jun
includes taxes & fees
9/10 Wonderful! (2,807 reviews)
"Good location"

Reviewed on 21 Jun 2026

Manchester Grand Hyatt San Diego
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is €326 per night from 28 Jun to 29 Jun
€326
28 Jun - 29 Jun
includes taxes & fees
8.8/10 Excellent! (2,657 reviews)
"We’ve stayed here for over 10+ years. Still an amazing choice for us. Please work on the landscaping. It used to look more lush."

Reviewed on 21 Jun 2026

Paradise Point Resort & Spa
See all 4,901 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa holiday package cost?
Starting from as low as , a holiday package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa holiday packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighbourhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa holiday?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your holiday time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're travelling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organising an island getaway in a villa or prefer to stay in a cosy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia holiday package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa holiday package?
Don't worry if you're rethinking your Otay Mesa holiday package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Popular places to visit

San Diego Zoo

San Diego Zoo

Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

San Diego Zoo
Mission Bay

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay
Petco Park

Petco Park

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park

Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster

€85
per adult
Tour of San Diego>Rosarito >Giant Christ>Puerto Nuevo Lobster
Crossing Borders: Tijuana Day Trip from San Diego

Crossing Borders: Tijuana Day Trip from San Diego

€80
per adult
92% of travellers recommend
Crossing Borders: Tijuana Day Trip from San Diego
From Tijuana: Valle de Guadalupe Shared Winery Tour

From Tijuana: Valle de Guadalupe Shared Winery Tour

€72
per adult
100% of travellers recommend
From Tijuana: Valle de Guadalupe Shared Winery Tour
See all activities in San Diego
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.