
Otay Mesa Holidays
- Plan, book, travel with confidence
- Better togetherSave up to €185 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place

The Sofia Hotel
Reviewed on 15 Dec 2025

Margaritaville Hotel San Diego Gaslamp Quarter
Reviewed on 14 Dec 2025

Hotel del Coronado, Curio Collection by Hilton
Reviewed on 6 Dec 2025

The Beau Downtown San Diego Gaslamp Quar
Reviewed on 7 Dec 2025

Rancho Bernardo Inn
Reviewed on 8 Nov 2025
Where to stay in Otay Mesa

Downtown San Diego
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Top hotels in Otay Mesa

Sheraton San Diego Resort
excellent hotel pre-cruise. great appetizers at Happy Hour! Very nice room.
Reviewed on 11 Dec 2025

Lafayette Hotel & Club
The hotel is big on charm and decor. It was in 1937 and the guest rooms haven’t been enlarged or highly modernized. What they did get is a big dash of kitsch. Clashing wall paper, canopied beds, retro appliances, and a huge room bar (you pay per drink). We took a second floor poolside room with a ...
Reviewed on 11 Dec 2025

The DEXTRO Little Italy, BW Premier Collection
Quite area. Close to Little Italy.
Reviewed on 11 Dec 2025
Frequently asked questions
Popular places to visit

San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do

Tour from San Diego to Rosarito / Portales / Puerto Nuevo Lobster

Crossing Borders: Tijuana Day Trip from San Diego




