
Otay Mesa Holidays
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Where to stay in Otay Mesa
Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa

Downtown San Diego
2 out of top 10 points of interest in this area
4.5/5(138 area reviews)
Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.
Top hotels in Otay Mesa

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
The price is €105 per night from 27 Aug to 28 Aug
€105
27 Aug - 28 Aug
includes taxes & fees
7.8/10 Good! (1,432 reviews)
"Staff"
Reviewed on 13 Aug 2025

Handlery Hotel
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
8/10 Very Good! (1,974 reviews)
"Quiet. Ok"
Reviewed on 18 Aug 2025

Wyndham San Diego Bayside
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is €173 per night from 4 Sept to 5 Sept
€173
4 Sept - 5 Sept
includes taxes & fees
8.2/10 Very Good! (5,849 reviews)
"Great time!"
Reviewed on 20 Aug 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
Popular places to visit

San Diego Zoo
Come and see the power and beauty of nature up close at one of the biggest and best zoos in America.

Mission Bay
Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Petco Park
Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.
Things to do

Crossing Borders: Tijuana Day Trip from San Diego
€80
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.