St. Louis Hotel Guide. Hotels in Penrose, St. Louis, United States of America

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18 Dec - 19 Dec
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19 Dec - 20 Dec
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19 Dec - 21 Dec
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26 Dec - 28 Dec

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Our top choices for Penrose hotels

Exterior
Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
24.2 km from Penrose
8.4 out of 10, Very good, (1007)
"Nice staff at reception. "
United States
Denise
The price is €75
includes taxes & fees
28 Dec - 29 Dec
Comfort Suites St Charles - St Louis
Lobby
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
24 km from Penrose
9.6 out of 10, Exceptional, (1000)
"Staff and hotel were amazing"
United States
Allison
The price is €114
includes taxes & fees
28 Dec - 29 Dec
Drury Plaza Hotel St. Louis St. Charles
Lobby
Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles

Embassy Suites by Hilton St. Louis St. Charles
3.5 star property
25 km from Penrose
8.6 out of 10, Excellent, (1008)
"I Loved it I would definitely stay there again"
United States
Roberta
The price is €120
includes taxes & fees
28 Dec - 29 Dec
Embassy Suites by Hilton St. Louis St. Charles
Free daily buffet breakfast
Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
24 km from Penrose
9.2 out of 10, Wonderful, (632)
"Clean room, great staff, liked the gym"
United States
Emily
The price is €101
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn & Suites St. Charles Old Town Area
Lobby sitting area
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
24.4 km from Penrose
8.0 out of 10, Very good, (1011)
"The room is decent for a night. The price is great and hotel staff is friendly. "
United States
Jordan
The price is €87
includes taxes & fees
24 Dec - 25 Dec
Best Western Plus The Charles Hotel
Premium bedding, desk, iron/ironing board, free cots/infant beds
Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
28.5 km from Penrose
8.0 out of 10, Very good, (1000)
"I'd stay at this place again. "
United States
Suzanne
The price is €74
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham St Charles
Exterior
Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO

Tru by Hilton St. Charles St. Louis, MO
2.5 star property
24.2 km from Penrose
8.6 out of 10, Excellent, (769)
"Great staff and room was so nice and comfortable "
United States
ED
The price is €88
includes taxes & fees
28 Dec - 29 Dec
Tru by Hilton St. Charles St. Louis, MO
Lobby
Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia

Hampton Inn St. Louis - Columbia
2.5 star property
26.3 km from Penrose
8.6 out of 10, Excellent, (476)
"Breakfast was great and a very good atten"
United States
John
The price is €91
includes taxes & fees
12 Jan - 13 Jan 2026
Hampton Inn St. Louis - Columbia
Exterior
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
23.9 km from Penrose
9.4 out of 10, Exceptional, (1001)
"Good stay."
United States
Steven
The price is €109
includes taxes & fees
11 Jan - 12 Jan 2026
Country Inn & Suites by Radisson, St. Charles Historic District
Room, 1 Queen Bed, Jetted Tub
Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach

Red Lion Inn & Suites Pontoon Beach
2.5 star property
17.4 km from Penrose
7.8 out of 10, Good, (573)
"Yes, very good, yes good breakfast, yes truck parking."
United States
mark
The price is €58
includes taxes & fees
2 Jan - 3 Jan 2026
Red Lion Inn & Suites Pontoon Beach
Lobby
Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights

Drury Inn & Suites St. Louis Fairview Heights
3.0 star property
23.5 km from Penrose
9.2 out of 10, Wonderful, (1003)
"I always stay at Drury whenever I can, you can always count on having a great stay! Clean rooms, complimentary cocktails, Hot breakfast, AND complimentary hors d’oeuvres!! "
United States
Lafonya
The price is €90
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites St. Louis Fairview Heights
Lobby
Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66

Best Western St. Louis-Kirkwood Route 66
3.5 star property
19.4 km from Penrose
8.4 out of 10, Very good, (1374)
"Excellent staff , location was great but the breakfast wasn’t very good"
United States
Christian
The price is €94
includes taxes & fees
21 Dec - 22 Dec
Best Western St. Louis-Kirkwood Route 66
Fridge, microwave, stovetop, dishwasher
Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City

Sonesta Simply Suites St Louis Earth City
2.0 star property
20.8 km from Penrose
8.6 out of 10, Excellent, (804)
"Always a great stay"
United States
Darnell
The price is €82
includes taxes & fees
7 Jan - 8 Jan 2026
Sonesta Simply Suites St Louis Earth City
Lobby
Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO

Motel 6 Hazelwood, MO
2.0 star property
16.7 km from Penrose
8.4 out of 10, Very good, (1618)
"great stay."
United States
Allison
The price is €62
includes taxes & fees
1 Jan - 2 Jan 2026
Motel 6 Hazelwood, MO
Exterior
Best Western Plus Parkway Hotel

Best Western Plus Parkway Hotel

Best Western Plus Parkway Hotel
2.5 star property
27.5 km from Penrose
8.2 out of 10, Very good, (1001)
"Room was clean and staff responded to my request for service."
United States
Sharon
The price is €69
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Parkway Hotel
Breakfast, dinner and brunch served
The Principal Hotel

The Principal Hotel

The Principal Hotel
3.5 star property
26.5 km from Penrose
9.8 out of 10, Exceptional, (191)
"Great place. Very nice rooms, new and clean."
United States
Jeff
The price is €107
includes taxes & fees
21 Dec - 22 Dec
The Principal Hotel
Lobby
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
13.3 km from Penrose
9.4 out of 10, Exceptional, (2745)
"Great place to stay before your early morning flight. "
United States
Henry
The price is €90
includes taxes & fees
23 Dec - 24 Dec
Pear Tree Inn St. Louis Airport
Indoor pool
Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
30.5 km from Penrose
8.0 out of 10, Very good, (1000)
"Good place to stay with pets"
United States
David
The price is €87
includes taxes & fees
4 Jan - 5 Jan 2026
Hampton Inn St. Charles St. Peters
Seasonal outdoor pool
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
23.6 km from Penrose
8.4 out of 10, Very good, (1000)
"Clean room, wonderful helpful pleasant staff, amenities, everything was great love staying here!"
United States
Robyn
The price is €166
includes taxes & fees
22 Dec - 23 Dec
Ameristar Casino Resort and Spa
Lobby
Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville
3.0 star property
19.8 km from Penrose
9.6 out of 10, Exceptional, (1002)
"Good food and options. Location is amazing."
United States
Jesus
The price is €96
includes taxes & fees
4 Jan - 5 Jan 2026
Drury Inn & Suites St. Louis Collinsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Penrose

Find the best Penrose areas for the activities you enjoy most.

Downtown St. Louis

Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Gateway Arch National Park – discover Downtown St. Louis, a destination also famous for its historic sites.

Clayton

Take time in Clayton to visit attractions like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. You might also appreciate the abundant dining options, and you can hop on the metro at Clayton Station to see more of the city.

St. Charles Historic District

St. Charles Historic District is known for its ample dining options, and you can make a stop by Historic Main Street and Missouri River while in the area.

Creve Coeur

Travellers come to Creve Coeur for its abundant dining options, and you can see top attractions like Creve Coeur Golf Club and Saint Louis Abbey while you're in town.

Central West End

Central West End

Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees.

Top Penrose Hotel Reviews

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

10/10 Excellent
"Everything was great, rooms were clean smelled great. Staff was super friendly and accommodating. Good value good environment highly recommend."
robert 1-night trip
Posted 12 hours ago
Pear Tree Inn St. Louis Airport

Frequently asked questions

What's it like in Penrose?
Travellers are sure to enjoy a stay in St. Louis's Penrose neighbourhood. Consider a visit to Julia Davis Branch Library as part of your Penrose travel plans.
If I need to cancel my hotel reservation in Penrose, will I receive a refund?
Yes! The majority of room reservations are refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of check in. If your reservation is non-refundable, you might still have the option to cancel and receive a refund within 24 hours of your booking. Put your dates in and click on "Search", then filter by "fully refundable" to get top deals in Penrose.
What is there to do around this St. Louis neighbourhood?
Julia Davis Branch Library is an attraction you might want to check out while you're in Penrose. Shelley House and Bellefontaine Cemetery are also worth a visit when you're out sightseeing in St. Louis.