Penrose Holidays
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Where to stay in Penrose
Find the best Penrose areas and neighborhoods for the activities you enjoy most. Learn more about Penrose
Downtown St. Louis
4 out of top 10 points of interest in this area
4.5/5(18 area reviews)
Gourmet restaurants beloved sports teams and top sights from Gateway Arch to Busch Stadium – discover Downtown St. Louis, a destination also famous for its historic sites.
Top hotels in Penrose
21C Museum Hotel St Louis
1528 Locust street St. Louis MO
Fully refundableReserve now, pay when you stay
The price is €136 per night from 22 Feb to 23 Feb
€136
22 Feb - 23 Feb
includes taxes & fees
9/10 Wonderful! (1,605 reviews)
Best hotel ever. Interesting. Comfortable. Quiet. Great location.
Reviewed on 13 Feb 2026
Clayton Plaza Hotel & Extended Stay
7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
The price is €103 per night from 26 Feb to 27 Feb
€103
26 Feb - 27 Feb
includes taxes & fees
8.8/10 Excellent! (3,090 reviews)
Love this older hotel that has kept up with the times. Love the excellent hot buffet breakfast, including cooked to order omelettes, that comes with the price of the room. Disappointed that the garage parking is no longer free, but hey, I can handle six dollars a night. Can’t beat the price for the ...
Reviewed on 16 Feb 2026
Pear Tree Inn St. Louis Airport
10810 Pear Tree Ln St. Ann MO
Fully refundableReserve now, pay when you stay
The price is €89 per night from 21 Feb to 22 Feb
€89
21 Feb - 22 Feb
includes taxes & fees
9.2/10 Wonderful! (2,811 reviews)
Room was spotless. Good night of sleep before a flight very happy with stay.
Reviewed on 9 Feb 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Popular places to visit
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
Things to do
St. Louis Ghost Tour: Sinister Sins & Shadows
€27
per adult
St. Louis Premium Small Group Tour With Arch & River Cruise
€134
per adult
84% of travellers recommend
Downtown St. Louis Smartphone Guided Audio Walking Tour App
€6
per adult
100% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.