San Marco Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €900 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in San Marco

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

5 out of 5
Localita Piazzano, C.P. 6 Cortona AR
The price is €673 per night from 19 Jun to 20 Jun
€673
19 Jun - 20 Jun
includes taxes & fees
9.8/10 Exceptional! (235 reviews)
"The Hotel and grounds are beautiful and immaculately maintained. The entire staff really stands out. So friendly and welcoming. Those little gestures of respect and kindness are appreciated. Also it’s very convenient that they can speak English. There are several beautiful hotels in the area to experience, ..."

Reviewed on 14 May 2026

Villa di Piazzano - Small Luxury Hotel of the World
TH Assisi - Hotel Cenacolo

TH Assisi - Hotel Cenacolo

4 out of 5
Viale Patrono d'Italia 70 Assisi PG
Fully refundableReserve now, pay when you stay
The price is €100 per night from 8 Jun to 9 Jun
€100
8 Jun - 9 Jun
includes taxes & fees
TH Assisi - Hotel Cenacolo
Hotel Sangallo Palace

Hotel Sangallo Palace

4 out of 5
Via L Masi 9 Perugia PG
Fully refundableReserve now, pay when you stay
The price is €141 per night from 7 Jun to 8 Jun
€141
7 Jun - 8 Jun
includes taxes & fees
8.8/10 Excellent! (638 reviews)
"The staff were very helpful (and patient!). Breakfasts were great, and location near the escalators to the main square brilliant. Taxis came promptly when ordered via the desk."

Reviewed on 24 May 2026

Hotel Sangallo Palace
See all 3,341 properties in San Marco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Perugina Chocolate Factory

Enjoy an outing to Perugina Chocolate Factory during your stay in San Sisto. Discover the area's jazz scene and cathedral.

Perugina Chocolate Factory

What to do in San Marco

Picture 3 for Activity Perugia: San Lorenzo Cathedral Audioguide Tour

Perugia: San Lorenzo Cathedral Audioguide Tour

€4
per adult
Perugia: San Lorenzo Cathedral Audioguide Tour
Assisi Seraphic Beauty Eco Tour

Assisi Seraphic Beauty Eco Tour

€15
per adult
Assisi Seraphic Beauty Eco Tour
Perugia: Chapter Museum Entry Ticket

Perugia: Chapter Museum entry ticket

€8
per adult
Perugia: Chapter Museum entry ticket
See all activities in San Marco

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.