San Sisto Holidays

  • Plan, book, travel with confidence

  • Better together

    Save up to €900 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in San Sisto

Villa di Piazzano - Small Luxury Hotel of the World

Villa di Piazzano - Small Luxury Hotel of the World

Localita Piazzano, C.P. 6 Cortona AR
€626
12 Sept - 13 Sept
includes taxes & fees
9.8/10 Exceptional! (247 reviews)
"Such a fantastic property, the most amazing food and great surroundings. Just a thoroughly lovely experience."

Reviewed on 3 Sept 2026

Villa di Piazzano - Small Luxury Hotel of the World
Giotto Hotel & Spa

Giotto Hotel & Spa

Via Fontebella 41 Assisi PG
Fully refundableReserve now, pay when you stay
€102
8 Sept - 9 Sept
includes taxes & fees
9/10 Wonderful! (827 reviews)
"Will be back very clean good view"

Reviewed on 3 Sept 2026

Giotto Hotel & Spa
TH Assisi - Hotel Cenacolo

TH Assisi - Hotel Cenacolo

Viale Patrono d'Italia 70 Assisi PG
Fully refundableReserve now, pay when you stay
€115
2 Oct - 3 Oct
includes taxes & fees
9.2/10 Wonderful! (691 reviews)
"Good place"

Reviewed on 15 Aug 2026

TH Assisi - Hotel Cenacolo
See all 3,579 properties in San Sisto
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular San Sisto attractions

Perugina Chocolate Factory

8.6/10 (58 reviews)
Enjoy an outing to Perugina Chocolate Factory during your stay in San Sisto. Discover the area's jazz scene and cathedral.
See properties

What to do in San Sisto

Assisi Seraphic Beauty Eco Tour

Assisi Seraphic Beauty Eco Tour

€15
per adult
Assisi Seraphic Beauty Eco Tour
Perugia: Chapter Museum entry ticket

Perugia: Chapter Museum entry ticket

€8
per adult
Perugia: Chapter Museum entry ticket
Perugia Scavenger Hunt and Highlights Self Guided Tour

Perugia Scavenger Hunt & Highlights Self-Guided Walking Tour

€3
per adult
Perugia Scavenger Hunt & Highlights Self-Guided Walking Tour
See all activities in San Sisto

Frequently asked questions

How much does a San Sisto holiday package cost?
You can snap up a holiday package to this destination on Expedia. However, how much your holiday to San Sisto costs will depend on factors like the season, hotel choice and length of stay.
What are the cheapest months to go to San Sisto?
You're likely to find lower prices and better availability in January, February and March. Browse our cheap San Sisto holiday packages and you could get some excellent off-season deals.
How many days is enough for San Sisto?
With a well-planned schedule, you can easily tick off the most popular San Sisto sights in a few days. But if you want to discover hidden gems or go on day trips, consider booking your San Sisto holiday for longer.
How to find the best San Sisto package deals?
Use Expedia's handy filters to help you find some great San Sisto package deals. When you start your search, simply set your maximum budget and then sort the results by "Price: low to high." If you want to save, plan your escape for midweek, or browse for San Sisto package deals in the off-season. Switch up your travel dates and you may score even better discounts. As a rule of thumb, it's typically best to book your holiday package as early as possible.
Is it cheaper to book a San Sisto holiday as a package?
Expedia holiday packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and you could save hundreds of dollars. You'll usually get a better deal than booking each component separately. And you'll still get the flexibility to create a tailored San Sisto holiday by choosing your favourite type of stay, airline and car class.
When to book a holiday package to San Sisto?
If you're planning a spur-of-the-moment San Sisto getaway, browse our last-minute deals that can be booked up to one week before you take off. Prefer not to wait until the last minute? You can land incredible deals on your hotels and flights by booking well in advance.
How to plan a trip to San Sisto?
  1. Choose your travel dates: What you'd like to do in San Sisto and your favourite season can help you decide when to go.
  2. Set a budget: Factor in costs like flights, food and transportation when working out how much to save for your trip to San Sisto. Then, choose a property that suits your budget, whether that's an affordable option or a more luxurious retreat.
  3. Determine how many days away: Start by making a list of all the activities and attractions you want to get to in San Sisto. Then, estimate how long you'll need for each, along with any travel time.
  4. Bundle your bookings: With your travel dates in order, you can combine your car rental, hotels, flights and more into a customised San Sisto holiday package.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.