Santa Cruz Holidays

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    Save up to €185 when you book a flight and hotel together*

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Top destinations in Santa Cruz

San Lorenzo Cathedral featuring a garden
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Santa Cruz

Santa Cruz

Top hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is €37 per night from 17 Jan to 18 Jan
€37
17 Jan - 18 Jan
9.4/10 Exceptional! (81 reviews)
Amazing breakfast

Reviewed on 7 Jan 2026

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is €84 per night from 11 Feb to 12 Feb
€84
11 Feb - 12 Feb
9/10 Wonderful! (213 reviews)
Muy bien exelente

Reviewed on 9 Dec 2025

Marriott Santa Cruz de la Sierra Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 out of 5
Ave. San Martin, #455 Santa Cruz
The price is €113 per night from 31 Jan to 1 Feb
€113
31 Jan - 1 Feb
8.8/10 Excellent! (350 reviews)
everything

Reviewed on 6 Jan 2026

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
See all 307 properties in Santa Cruz
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?
We make it simple to travel the world, with Santa Cruz holiday packages starting from as little as . You'll have the flexibility to combine your favourite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?
How do I get a cheap travel package to Santa Cruz?
One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.
What are the top hotels in Santa Cruz?
For properties in Samaipata with cosy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.
How far in advance should I book my Santa Cruz holiday?
It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.
What does an Expedia Santa Cruz travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favourite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.
What should I know before booking a Santa Cruz travel package?
Bundling your bookings into a Santa Cruz holiday package is the most convenient way to organise your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?
Can I choose my airline with a Santa Cruz Expedia holiday package?
Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organising your Santa Cruz getaway.
If I'm not able to travel, can I cancel my Santa Cruz holiday package?
Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz holiday package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.

Popular places to visit

Plaza 24 de Septiembre featuring heritage elements and heritage architecture as well as a large group of people

Plaza 24 de Septiembre

The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.

Plaza 24 de Septiembre

Cine Center

You can make plans for a show at Cine Center on your trip to Santa Cruz. While in the area, you can find time to visit its shops.

Cine Center

Franco Aleman Cultural Center

You can enjoy some culture when you stop by Franco Aleman Cultural Center in Santa Cruz. While in the area, you can find time to visit its shops.

Franco Aleman Cultural Center

What to do in Santa Cruz

Vallegrande City

Vallegrande City Tour

€25
per adult
Vallegrande City Tour
Wildlife rescue center and preservation park

Santa Cruz: Wildlife Sanctuary and Preservation Park Tour

€72
per adult
Santa Cruz: Wildlife Sanctuary and Preservation Park Tour
Tickets Admission Ernesto Che Guevara Historical Museum in Vallegrande

Guided visit to the Che Guevara Memorial in Vallegrande

€16
per adult
Guided visit to the Che Guevara Memorial in Vallegrande
See all activities in Santa Cruz
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.