Santa Cruz Holidays

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Save up to €900 when you book a flight and hotel together*
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Top destinations in Santa Cruz

A colonial-style building with a bell tower, palm trees, and a paved walkway.

Where to stay in Santa Cruz

Find the best Santa Cruz areas for the activities you enjoy most.

Hamacas

Hamacas

When in Hamacas, you can plan a visit to Santa Cruz Zoo and Las Brisas Shopping Center, some noteworthy sights in the nearby area.

Find hotel + flight trips in Hamacas

Top hotels in Santa Cruz

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ave. San Martin, #455 Santa Cruz

€116

3 Sept - 4 Sept

9/10 Wonderful! (402 reviews)

"Las piscinas son buenazas, la comida también, súper bien ubicado. Pero hay una zona que no tiene ascensor si te toca cuarto ahí y tienes silla de ruedas avisar"

Reviewed on 28 Aug 2026

Camino Real Hotel

Av. San Martín y 4to. Anillo Santa Cruz

€124

14 Sept - 15 Sept

Ibis Santa Cruz DE LA Sierra

AVENIDA CRISTOBAL DE MENDOZA Santa Cruz

€31

12 Sept - 13 Sept

9.4/10 Exceptional! (134 reviews)

"Buen hotel Limpio y comodo"

Reviewed on 21 Aug 2026

See all 335 properties in Santa Cruz

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Cruz holiday package cost?

We make it simple to travel the world, with Santa Cruz holiday packages starting from as little as . You'll have the flexibility to combine your favourite airlines, hotels and car rental. For the ultimate getaway, why not add a couple of tours and activities to your itinerary?

How do I get a cheap travel package to Santa Cruz?

One of the easiest ways to save money (and time) is to bundle your bookings with Expedia. Hotels, rental cars, flights and activities — we've got them all covered. Pick a combination that best fits you and watch your savings pile up. Of course, a travel package is never a one-size-fits-all. That's why we offer more than 550 partner airlines and 1,000,000 properties across the world, which lets you customize your Santa Cruz adventure.

What are the top hotels in Santa Cruz?

For properties in Samaipata with cosy beds and friendly service, look up Sun Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel. If you're swinging by San Jose de Chiquitos as well, you'll get a great night's sleep at Camino Real Hotel or Marriott Santa Cruz de la Sierra Hotel.

How far in advance should I book my Santa Cruz holiday?

It's hard to pick the best time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to 12 months in advance. If you're booking late, don't stress. Discounted prices occasionally appear within a few weeks of departure dates.

What does an Expedia Santa Cruz travel package include?

Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your favourite combination. After you've made your booking, you can add on the exciting stuff like activities and tours. Our travel packages make it simple to create an exciting Santa Cruz escape.

What should I know before booking a Santa Cruz travel package?

Bundling your bookings into a Santa Cruz holiday package is the most convenient way to organise your trip. Not only that, you'll save just for combining your hotels, flights and car rentals. Once you've booked, why not add on a day tour or an activity?

Can I choose my airline with a Santa Cruz Expedia holiday package?

Yes — that's one of the best things about an Expedia package. You're in control. We have more than 550 airline partners throughout the world, so you have loads of choice when organising your Santa Cruz getaway.

If I'm not able to travel, can I cancel my Santa Cruz holiday package?

Yes you can, and we'll help you every step of the way. You may be able to change or cancel your Santa Cruz holiday package at no cost within 24 hours of booking. However, you may be charged a fee by your hotel, airline or car rental company if you booked more than 24 hours ago. If life throws you a curveball, browse our Customer Service Portal for more information.