Gainesville Hotel Guide - Santa Fe Depot Museum hotels in Gainesville, United States of America.

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Tonight
25 Dec - 26 Dec
Tomorrow
26 Dec - 27 Dec
This weekend
26 Dec - 28 Dec
Next weekend
2 Jan - 4 Jan

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Our top choices for Santa Fe Depot Museum hotels

Property grounds
The Lancaster Manor B&B

The Lancaster Manor B&B

The Lancaster Manor B&B
3.5 star property
0.8 km from Santa Fe Depot Museum
10.0 out of 10, Exceptional, (85)
"This place deserves 6 stars, John and Connie are truly outstanding people, every detail is meticulously taken care of, breakfast was perfect and everything is made from the scratch. This house does not feel like a hotel, feels like home ❤️"
United States
Nestor
The price is €162
includes taxes & fees
5 Jan - 6 Jan 2026
The Lancaster Manor B&B
Free daily continental breakfast
Fairfield Inn & Suites by Marriott Gainesville I-35

Fairfield Inn & Suites by Marriott Gainesville I-35

Fairfield Inn & Suites by Marriott Gainesville I-35
2.5 star property
1.8 km from Santa Fe Depot Museum
8.8 out of 10, Excellent, (1000)
"Great value for a property located near Winstar casino."
United States
Thomas
The price is €85
includes taxes & fees
6 Jan - 7 Jan 2026
Fairfield Inn & Suites by Marriott Gainesville I-35
Free daily buffet breakfast
Holiday Inn Express Hotel & Suites Gainesville by IHG

Holiday Inn Express Hotel & Suites Gainesville by IHG

Holiday Inn Express Hotel & Suites Gainesville by IHG
2.5 star property
1.1 km from Santa Fe Depot Museum
7.8 out of 10, Good, (1002)
"Wonderful hotel"
United States
Blake
The price is €83
includes taxes & fees
7 Jan - 8 Jan 2026
Holiday Inn Express Hotel & Suites Gainesville by IHG
Free daily on-the-go breakfast
Days Inn by Wyndham Gainesville

Days Inn by Wyndham Gainesville

Days Inn by Wyndham Gainesville
2.5 star property
2.5 km from Santa Fe Depot Museum
7.6 out of 10, Good, (1000)
"It was my first time staying here room is very nice clean and staff was very friendly. They have very great complementary breakfast too highly recommend anyone coming to the area to stay here very reasonable and great pricing."
United States
quy
The price is €74
includes taxes & fees
10 Jan - 11 Jan 2026
Days Inn by Wyndham Gainesville
Lobby
Super 8 by Wyndham Gainesville TX

Super 8 by Wyndham Gainesville TX

Super 8 by Wyndham Gainesville TX
2.0 star property
2.7 km from Santa Fe Depot Museum
7.2 out of 10, Good, (1008)
"The breakfast menu was good and the service was good "
United States
Tunis
The price is €67
includes taxes & fees
5 Jan - 6 Jan 2026
Super 8 by Wyndham Gainesville TX
Indoor pool
Comfort Suites Gainesville

Comfort Suites Gainesville

Comfort Suites Gainesville
2.5 star property
2.5 km from Santa Fe Depot Museum
6.6 out of 10, (1001)
"I really enjoyed myself!!! Thanks!"
United States
Frank
The price is €69
includes taxes & fees
4 Jan - 5 Jan 2026
Comfort Suites Gainesville
Lobby
Budget Host Motel Gainesville

Budget Host Motel Gainesville

Budget Host Motel Gainesville
2.5 star property
2.7 km from Santa Fe Depot Museum
6.6 out of 10, (494)
"The staff was very nice, I was checked in quickly and my room was very clean. "
United States
Jermeka
The price is €54
includes taxes & fees
7 Jan - 8 Jan 2026
Budget Host Motel Gainesville
Lobby
Quality Inn Gainesville

Quality Inn Gainesville

Quality Inn Gainesville
2.5 star property
0.9 km from Santa Fe Depot Museum
6.0 out of 10, (1001)
"Very Clean room, spacious, breakfast. "
United States
Maribel
The price is €52
includes taxes & fees
9 Jan - 10 Jan 2026
Quality Inn Gainesville
Lobby
Suburban Studios Gainesville

Suburban Studios Gainesville

Suburban Studios Gainesville
2.0 star property
0.9 km from Santa Fe Depot Museum
5.8 out of 10, (169)
"I enjoyed my stay. "
United States
Jennifer
The price is €46
includes taxes & fees
30 Dec - 31 Dec
Suburban Studios Gainesville
Desk, iron/ironing board, free WiFi, bed sheets
Hampton Inn & Suites Gainesville

Hampton Inn & Suites Gainesville

Hampton Inn & Suites Gainesville
2.5 star property
6.4 km from Santa Fe Depot Museum
8.6 out of 10, Excellent, (1000)
"clean rooms and pretty good breakfast"
United States
Bruce
The price is €75
includes taxes & fees
20 Jan - 21 Jan 2026
Hampton Inn & Suites Gainesville
Lobby
La Quinta Inn & Suites by Wyndham Gainesville

La Quinta Inn & Suites by Wyndham Gainesville

La Quinta Inn & Suites by Wyndham Gainesville
3.0 star property
6.8 km from Santa Fe Depot Museum
8.0 out of 10, Very good, (1001)
"Nice place to stay!"
United States
Renee
The price is €75
includes taxes & fees
5 Jan - 6 Jan 2026
La Quinta Inn & Suites by Wyndham Gainesville
Room, 2 Queen Beds, Non Smoking
Lindsay Inn

Lindsay Inn

Lindsay Inn
2.0 star property
7.9 km from Santa Fe Depot Museum
8.2 out of 10, Very good, (749)
"I stay here for business and it's always safe and quiet."
United States
Tracy
The price is €60
includes taxes & fees
5 Jan - 6 Jan 2026
Lindsay Inn
Exterior
Best Western Red River Inn & Suites

Best Western Red River Inn & Suites

Best Western Red River Inn & Suites
2.5 star property
13.9 km from Santa Fe Depot Museum
9.0 out of 10, Wonderful, (1017)
"Have stayed here several times always clean room and good breakfast."
United States
Scott
The price is €91
includes taxes & fees
7 Jan - 8 Jan 2026
Best Western Red River Inn & Suites
Grand House | Breakfast area
Towering Oaks Event & Retreat Center

Towering Oaks Event & Retreat Center

Towering Oaks Event & Retreat Center
3.5 star property
15.4 km from Santa Fe Depot Museum
9.8 out of 10, Exceptional, (32)
"The accommodations and amenities were great. Mike and his mother were professional & accommodating and made us feel welcome. "
United States
Delana
The price is €157
includes taxes & fees
19 Jan - 20 Jan 2026
Towering Oaks Event & Retreat Center
Superior Room
Red River Inn And Suites

Red River Inn And Suites

Red River Inn And Suites
2.5 star property
13.9 km from Santa Fe Depot Museum
7.4 out of 10, Good, (1090)
"Been here a few times, nice friendly staff "
United States
Melody
The price is €94
includes taxes & fees
30 Dec - 31 Dec
Red River Inn And Suites
Room, 1 King Bed
OYO Hotel Valley View TX, I-35

OYO Hotel Valley View TX, I-35

OYO Hotel Valley View TX, I-35
2.5 star property
16.5 km from Santa Fe Depot Museum
8.0 out of 10, Very good, (497)
"We stayed here for one night and it was a great experience. Front desk staff was extremely kind and welcoming. The room was nice and cool and very clean. Will definitely stay here again."
United States
Carrie
The price is €73
includes taxes & fees
28 Dec - 29 Dec
OYO Hotel Valley View TX, I-35
Property grounds
Oak Meadow Ranch

Oak Meadow Ranch

Oak Meadow Ranch
2.0 star property
15 km from Santa Fe Depot Museum
The price is €509
includes taxes & fees
26 Dec - 27 Dec
Oak Meadow Ranch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Fe Depot Museum Hotel Reviews

Hampton Inn & Suites Gainesville

Hampton Inn & Suites Gainesville

10/10 Excellent
"clean rooms and pretty good breakfast"
Bruce 1-night trip
Posted 1 day ago
Hampton Inn & Suites Gainesville

Hotels near other Santa Fe Depot Museum attractions

Cooke County Courthouse

3.8/5 (15 reviews)
After visiting Cooke County Courthouse, make a plan to see the other sights and activities in Gainesville. While you're in the area, find time to visit its casinos.
See properties

Depot Park

Depot Park is just one of the places to see in Gainesville, so why not enjoy the other things to explore during your travels? While in this family-friendly area, find time to visit its casinos.
See properties

Frequently asked questions

What's the area like around Santa Fe Depot Museum?
Santa Fe Depot Museum is located in a welcoming area of Gainesville known for its first-class casinos. If you're looking for a convenient place to stay, take a look at the 15 hotels and other accommodation options you'll find within a mile.
What's the best place to stay near Santa Fe Depot Museum?
Suburban Studios Gainesville is one of the top choices for your stay based on our traveller data, and this hotel offers free WiFi and flat-screen TVs. It's located just a short 0.6 mi (0.9 km) from Santa Fe Depot Museum. Other good options within a short distance include Quality Inn Gainesville and Holiday Inn Express Hotel & Suites Gainesville by IHG.
How many hotels are there near Santa Fe Depot Museum?
Expedia has 15 hotels and other accommodation options within a mile from Santa Fe Depot Museum.
If I need to cancel the hotel reservation for my stay near Santa Fe Depot Museum, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of check in. If you booked a non-refundable reservation, you might be able to cancel it and get a refund within a 24-hour period of booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to review the best deals near Santa Fe Depot Museum.
What can I see and do near Santa Fe Depot Museum?
You can enjoy live performances at Butterfield Stage Players and State Theater. Get outside and spend some time strolling around Leonard Park, Tom Thumb Park and Jaycee Park. Gainesville War Memorial and Frank Buck Zoo are both worth a visit while you're out exploring.