Holiday Rentals in Santee

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Our top choices for Santee holiday rentals

Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion
4.0 star property
Santee
9.2 out of 10, Wonderful, (21)
"Excellent "
United States
John
Wyndham Vacation Resorts Lake Marion

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (37)
"Amazing host, comfy furniture, the fenced in yard was perfect for our fur babies! Hope to stay here again. 1.2 miles away from I-95! "
United States
Lauren B.
The price is €293
includes taxes & fees
22 Dec - 23 Dec
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Lake Marion - Majestic Big Water View!

Lake Marion - Majestic Big Water View!
Santee
10.0 out of 10, Exceptional, (9)
"Very very nice. Would recommend it for a great stay. "
United States
susan l.
Lake Marion - Majestic Big Water View!

Charming 2 Bedroom Waterfront Lake Marion Condo

Charming 2 Bedroom Waterfront Lake Marion Condo
Santee
10.0 out of 10, Exceptional, (6)
"Fantastic location on the lake and access to the pool as well. Home was clean and had everything we needed for our stay. Amazing communication with the owner. Will stay again."
United States
Erin B.
Charming 2 Bedroom Waterfront Lake Marion Condo

Sunsets on Lake Marion

Sunsets on Lake Marion
Santee
9.4 out of 10, Exceptional, (15)
"Great place to stay. "
United States
James
Sunsets on Lake Marion

Tranquil Getaways W/Heated Pool and Fishing

Tranquil Getaways W/Heated Pool and Fishing
Elloree
8.4 out of 10, Very good, (6)
"Great property the pool was so fun! Mostly stayed on the property and lounged around for a nice relaxing stay!"
United States
Tori P.
The price is €185
includes taxes & fees
2 Jan - 3 Jan 2026
Tranquil Getaways W/Heated Pool and Fishing

Beautiful, ground level 3-bedroom condo with pool on scenic Lake Marion

Beautiful, ground level 3-bedroom condo with pool on scenic Lake Marion
Santee
Beautiful, ground level 3-bedroom condo with pool on scenic Lake Marion

Lakeside vacationing close to golf courses, restaurants and boat rental company!

Lakeside vacationing close to golf courses, restaurants and boat rental company!
Santee
9.6 out of 10, Exceptional, (9)
"I had a very nice time and I will definitely come back here"
United States
Anna
Lakeside vacationing close to golf courses, restaurants and boat rental company!

Lakeside Charming 2-bedroom house in lovely Santee with AC, WiFi

Lakeside Charming 2-bedroom house in lovely Santee with AC, WiFi
Santee
Lakeside Charming 2-bedroom house in lovely Santee with AC, WiFi

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (11)
"Nice place great location "
United States
Jeffrey H.
The price is €374
includes taxes & fees
12 Jan - 13 Jan 2026
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Elloree Vacation Rental ~ 7 Mi to Lake Marion!

Elloree Vacation Rental ~ 7 Mi to Lake Marion!
3.0 star property
Santee
Elloree Vacation Rental ~ 7 Mi to Lake Marion!

Lake Side Condo Getaway

Lake Side Condo Getaway
Santee
8.4 out of 10, Very good, (8)
"Very clean and the view from balcony was awesome. Thanks for everything."
United States
Sherry E.
Lake Side Condo Getaway

Bells Marina & Resort

Bells Marina & Resort
2.5 star property
Eutawville
8.6 out of 10, Excellent, (79)
"Room was clean with a beautiful view of the Lake."
United States
Melanie
Bells Marina & Resort

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6

Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6
2.0 star property
Summerton
9.6 out of 10, Exceptional, (15)
"Convenient location, enjoyed fishing from dock in front too. Just right for quick fishing trip."
United States
Chris R.
The price is €138
includes taxes & fees
21 Dec - 22 Dec
Lakefront tiny cabin amazing view on Lake Marion! Pet friendly & sleeps 6

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable
Summerton
9.6 out of 10, Exceptional, (244)
"Great property in a quiet cove just minutes by boat from lake and marinas!"
United States
Christopher B.
SANITIZED! Lake Marion Lakefront Sandy Beach, Ramp, Sleeps 19, Wi-Fi Cable

Lake Marion Lakehouse with 180° lake view

Lake Marion Lakehouse with 180° lake view
Elloree
10.0 out of 10, Exceptional, (74)
"Overall very relaxing and quiet. Host were very accommodating with check in and out. "
United States
Anonymous traveller
Lake Marion Lakehouse with 180° lake view

Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS

Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS
Summerton
10.0 out of 10, Exceptional, (162)
"Always enjoy our stay"
United States
Tabitha K.
Deep water Lake Marion house. 4BR 2.5BA. Fish off dock. Nearby Golf. SUNSETS

Pet friendly country cottage with large fenced-in yard & horses on property

Pet friendly country cottage with large fenced-in yard & horses on property
Holly Hill
10.0 out of 10, Exceptional, (123)
"Wonderful experience! So quiet, beautiful surroundings & very helpful hosts! "
United States
Jen S.
The price is €193
includes taxes & fees
15 Jan - 16 Jan 2026
Pet friendly country cottage with large fenced-in yard & horses on property

Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy

Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy
Manning
9.8 out of 10, Exceptional, (95)
"Everything was as represented very clean and a very nice place to stay.You have a wonderful place and we hope to stay here more."
United States
Kennrth T.
Lake Marion's Big Red House. W/ Dock and Kayaks. Pet Friendly please read policy

Beautiful lake home to make your family vacation extra special!

Beautiful lake home to make your family vacation extra special!
Summerton
9.0 out of 10, Wonderful, (59)
"The entire home was spotless "
United States
Paola
Beautiful lake home to make your family vacation extra special!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santee Hotel Reviews

Find out more about Santee

Everything you need to know about Santee holiday rentals

Whether you’re excited for the perfect family holiday, a romantic getaway for two, or the ultimate city break, we’ve got the Santee holiday rental for you. At Expedia, you can take your pick from private holiday homes, apartments, cottages, apart-hotels, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Santee holiday rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

Santee holiday rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Santee. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Santee holiday rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a holiday rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Santee holiday rentals we have selected for you start as low as €138 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Santee rentals

At Expedia, we put the best Santee holiday rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Santee rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Santee holiday.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Santee. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

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Frequently asked questions

Can I find holiday rentals in Santee?

Yes, there are holiday rentals close to the most popular sights in Santee, or you can select a more secluded option if you're looking for a relaxing stay. Tourists appreciate the top-notch restaurants and coffee shops in Santee. Make sure you have time to check out the golf courses and lake views during your trip.

What are some of the best holiday rentals that Santee has to offer?

Wyndham Vacation Resorts Lake Marion: This highly rated holiday home rental in Santee is equipped with an outdoor pool, free WiFi and cable TV to help you feel comfortable during your stay. Kitchen amenities include a full-sized fridge, a dishwasher and a stovetop. Another good choice for your trip to Santee is Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!.

How many holiday rentals are there in Santee?

Expedia has 9 holiday rentals for your stay in Santee.

What can I see and do in Santee?

While you're exploring the area, Lake Marion and Santee National Wildlife Refuge are a couple of picturesque spots to get outside and enjoy nature. Santee Cooper Country Club and Santee State Park are other places to visit while you're in town.

What are holiday rentals like in Santee?

Holiday rentals are privately owned properties you can book for a few days, or a quick weekend, in Santee. Holiday rentals feature amenities like kitchens and laundry facilities so your stay will be comfortable. If you're concerned about a sanitised environment, holiday rentals can provide a sense of security away from public hotel lifts and busy reception areas while still allowing you the enjoyment of travel. You'll also have more space in a holiday rental than in a standard hotel, which is another reason why a holiday rental is a great option for small groups.