Santee Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
12 Jan - 13 Jan
Tomorrow
13 Jan - 14 Jan
This weekend
16 Jan - 18 Jan
Next weekend
23 Jan - 25 Jan

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Santee hotels

Free daily buffet breakfast
Tru By Hilton Santee

Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (675 reviews)
"Stay was great felt so welcomed "
United States
Jesse
The price is €102
includes taxes & fees
26 Jan - 27 Jan
Tru By Hilton Santee
Property amenity
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
2.5 star property
Santee
9.8 out of 10, Exceptional, (1,003 reviews)
"Clean spacious room, nice amenities and good breakfast. "
United States
Donna
The price is €115
includes taxes & fees
19 Jan - 20 Jan
Fairfield Inn & Suites by Marriott Santee
Room, 2 Queen Beds, Non Smoking
Baymont by Wyndham Santee

Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,434 reviews)
"Always a great stay. Clean room, friendly staff "
United States
Angela
The price is €72
includes taxes & fees
14 Jan - 15 Jan
Baymont by Wyndham Santee
Free breakfast
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,003 reviews)
"Great place to stop on a road trip! Breakfast was great, pets allowed, friendly staff. "
United States
Stephanie
The price is €123
includes taxes & fees
25 Jan - 26 Jan
Hampton Inn Santee-I-95
Exterior
Best Western Plus Santee Inn

Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,003 reviews)
"Nice rooms and very good breakfast items."
United States
Stephen
The price is €113
includes taxes & fees
19 Jan - 20 Jan
Best Western Plus Santee Inn
Exterior
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (986 reviews)
"Very good"
China
Wendeng
The price is €107
includes taxes & fees
8 Feb - 9 Feb
Holiday Inn Santee by IHG
Frette Italian sheets, premium bedding, pillow-top beds
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,002 reviews)
"Clean rooms, nice staff, decent breakfast "
United States
Dale
The price is €98
includes taxes & fees
26 Jan - 27 Jan
Comfort Inn & Suites Santee
In-room safe, iron/ironing board, free WiFi, bed sheets
Travelodge by Wyndham Santee

Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.0 out of 10, Good, (687 reviews)
"Nice quiet room and a delicious breakfast at a reasonable rate."
United States
Joseph B
The price is €53
includes taxes & fees
18 Jan - 19 Jan
Travelodge by Wyndham Santee
Exterior
Red Roof Inn Santee

Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (642 reviews)
"A good option if traveling with pets. The hotel is clean and well maintained but dated. "
United States
Karen
The price is €67
includes taxes & fees
15 Jan - 16 Jan
Red Roof Inn Santee
Lobby
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

Super 8 by Wyndham Santee
2.0 star property
Santee
6.8 out of 10, (441 reviews)
"The staff was very friendly and helpful. Room was clean and beds were so comfortable. "
United States
Kathy
The price is €72
includes taxes & fees
14 Jan - 15 Jan
Super 8 by Wyndham Santee
Free daily full breakfast
Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (464 reviews)
"Most importantly room was clean. Check in was good. "
United States
Marjan
The price is €57
includes taxes & fees
18 Jan - 19 Jan
Quality Inn & Suites Santee I-95
Lobby
Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (548 reviews)
"The grounds and property were clean and you could tell they take pride in what they're offering."
United States
Eric
The price is €58
includes taxes & fees
19 Jan - 20 Jan
Ramada by Wyndham Santee I-95
Desk, iron/ironing board, free WiFi, bed sheets
Econo Lodge Santee

Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (310 reviews)
"Last minute arrangements stay was quiet and peaceful "
United States
Iasia
The price is €60
includes taxes & fees
26 Jan - 27 Jan
Econo Lodge Santee
Free daily buffet breakfast
Tru by Hilton Orangeburg

Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1,006 reviews)
"Great stay"
United States
Thomas
The price is €101
includes taxes & fees
28 Jan - 29 Jan
Tru by Hilton Orangeburg
Lobby
Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
2.5 star property
Orangeburg
8.4 out of 10, Very good, (709 reviews)
"Overall a great place to stay!"
United States
Troy
The price is €80
includes taxes & fees
22 Jan - 23 Jan
Fairfield Inn by Marriott Orangeburg
Exterior
Hampton Inn & Suites Orangeburg

Hampton Inn & Suites Orangeburg

Hampton Inn & Suites Orangeburg
2.5 star property
Orangeburg
9.4 out of 10, Exceptional, (769 reviews)
"Quiet and clean"
United States
Deborah
The price is €109
includes taxes & fees
1 Feb - 2 Feb
Hampton Inn & Suites Orangeburg
Desk, laptop workspace, iron/ironing board, free WiFi
SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning

SureStay Hotel by Best Western Manning
2.5 star property
Manning
8.6 out of 10, Excellent, (1,003 reviews)
"Staff great, room clean"
United States
Jeanne
The price is €85
includes taxes & fees
1 Feb - 2 Feb
SureStay Hotel by Best Western Manning
Seasonal outdoor pool
Spark by Hilton Orangeburg

Spark by Hilton Orangeburg

Spark by Hilton Orangeburg
2.5 star property
Orangeburg
7.8 out of 10, Good, (1,004 reviews)
"Clean rooms, good location, nice and polite staff"
United States
Kenya
The price is €83
includes taxes & fees
1 Feb - 2 Feb
Spark by Hilton Orangeburg
Property amenity
SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg

SpringHill Suites by Marriott Orangeburg
2.5 star property
Orangeburg
8.8 out of 10, Excellent, (685 reviews)
"Nice roomy clean rooms, staff were great, indoor heated pool was nice accomadation for this time of year for the kids. "
United States
Lisa
The price is €108
includes taxes & fees
18 Jan - 19 Jan
SpringHill Suites by Marriott Orangeburg
Exterior
Holiday Inn Express & Suites Orangeburg by IHG

Holiday Inn Express & Suites Orangeburg by IHG

Holiday Inn Express & Suites Orangeburg by IHG
2.5 star property
Orangeburg
8.6 out of 10, Excellent, (797 reviews)
"Accommodations were great. The staff is very courteous. Overall I enjoyed my stay."
United States
Calvin
The price is €125
includes taxes & fees
26 Jan - 27 Jan
Holiday Inn Express & Suites Orangeburg by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular Santee attractions

Santee State Park

4.0/5 (112 reviews)
You can take time to visit Santee State Park during your travels to Santee. While you're here, you can savour the top-notch restaurants.
See properties

Santee Cooper Country Club

3.9/5 (47 reviews)
Enjoy a round of golf in Santee at Santee Cooper Country Club. While you're here, you can savour the top-notch restaurants.
See properties

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campsites.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Top Santee Hotel Reviews

Tru By Hilton Santee

Tru By Hilton Santee

10/10 Excellent
"Visit was excellent "
Robert S 1-night trip
Posted 3 days ago
Tru By Hilton Santee

More cheap stays in Santee

Baymont by Wyndham Orangeburg North

Baymont by Wyndham Orangeburg North

3583 Saint Matthews Rd Orangeburg SC
The price is €53 per night from 22 Jan to 23 Jan
€53
22 Jan - 23 Jan
includes taxes & fees
5.8/10 (1,001 reviews)

Frequently asked questions

Where is the best place for a stay in Santee?
Hampton Inn Santee-I-95 is a favourite property for Expedia customers. This hotel offers free breakfast and free parking. Other top choices based on traveller reviews include Fairfield Inn & Suites by Marriott Santee and Tru By Hilton Santee. See all available top hotels, or vacation rentals in Santee.
What are some of the best holiday rentals that Santee has to offer?
Wyndham Vacation Resorts Lake Marion: This highly rated holiday home rental in Santee is equipped with an outdoor pool, cable TV and free WiFi to help you feel comfortable during your stay. Kitchen amenities include a full-sized fridge, a dishwasher and a stovetop. Our travellers also rate Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! as a favourite home for rent in Santee. See all vacation rentals in Santee.
If I need to cancel my hotel reservation in Santee, will I receive a refund?
Yes, you'll find most room reservations are fully refundable as long as you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of check in. If your reservation is non-refundable, you might be able to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santee.
What's the best place to stay on a budget in Santee?
Based on reviews, Baymont by Wyndham Santee is a popular hotel for our travellers who want a more economical choice, and features free breakfast and free Wi-Fi. View all budget hotels in Santee.
What's the best family accommodation in Santee?
Comfort Inn & Suites Santee is a hotel with free parking and free buffet breakfast, and it's a top choice on Expedia for families. Fairfield Inn & Suites by Marriott Santee is another good option for your stay with the kids. Find more child-friendly accommodations in Santee.
What is the top LGBTQ-friendly accommodation in Santee?
Fairfield Inn & Suites by Marriott Santee is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Hampton Inn Santee-I-95 and Holiday Inn Santee by IHG are two other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santee.
What's the best dog-friendly hotel in Santee?
Tru By Hilton Santee is a top dog-friendly hotel, and offers an indoor pool along with free WiFi for its human guests. Two other good options for you and your pet include Baymont by Wyndham Santee and Hampton Inn Santee-I-95. See more pet-friendly hotel accommodations in Santee.
What's the best accommodation for a golf trip to Santee?
Holiday Inn Santee by IHG is a top hotel that has an adjacent golf course and features free WiFi. Other good options to stay near a golf course include Ramada by Wyndham Santee I-95 and Super 8 by Wyndham Santee. Visit Santee Cooper Country Club or Santee National Golf Club to perfect your golf swing. See more golf hotels in Santee.
What are some accommodation options with pools in Santee?
Fairfield Inn & Suites by Marriott Santee is a top hotel with a pool, free buffet breakfast and free WiFi. Quality Inn & Suites Santee I-95 is an additional hotel with an on-site pool. View all hotels with pools in Santee.
What is staying in Santee like?
Families will find child-friendly activities in Santee, and visitors give high marks for the top-notch restaurants. This welcoming city also attracts tourists with its golf courses and cafes. In Santee, there are 125 hotels and other accommodation options to choose from. Find out more about Santee.
What are the top places to visit in Santee?
Favourite places to visit include Santee Cooper Country Club, Santee National Golf Club and Santee State Park. A couple of additional sights to add to your itinerary are Lake Marion and Santee Town Hall. Take a look at what more there is to see and do in Expedia's Santee guide.
What's the seasonal weather like in Santee?
The hottest months are usually July and August, with an average temperature of 26°C, while the coldest months are January and February, with an average of 11°C. Average annual precipitation for Santee is 1397 mm.

Explore a world of travel with Expedia