
Santi Cosma e Damiano Holidays
- Plan, book, travel with confidence
Better together
Save up to €185 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place
Top Flight + Hotel Deals in Santi Cosma e Damiano
Price found within the past 48 hours. Click for updated prices.



Relais de la Poste
Rome City Centre
Save 100% on your flight
per person
26 Sept - 29 Sept
found 1 day ago
Return flight included
Dublin (DUB) to Rome (FCO)
9.2/10 Wonderful! (544 reviews)
Everything was amazing!! The workers were so sweet and helpful and truly made our stay. The room was extremely quiet for such a busy area. Check in and check out was easy and the room comes with free espresso! We loved everything about our stay and would definitely recommend.
Reviewed on 4 Aug 2025

Exe International Palace
Rome City Centre
per person
12 Sept - 19 Sept
found 20 hours ago
Return flight included
Dublin (DUB) to Rome (FCO)
7.8/10 Good! (1,002 reviews)
They should change the name. Not a palace hotel layout is confusing. Lobby, random old furniture just don’t look like a hotel. They med to spend money on common areas rugs, get rid of they lobby furniture and the two pots of ugly plastic flower at front entry is the first impression
Reviewed on 11 Jul 2025

Hotel Adriano Rooftop
Rome City Centre
per person
12 Sept - 19 Sept
found 20 hours ago
Return flight included
Dublin (DUB) to Rome (FCO)
9.6/10 Exceptional! (69 reviews)
centrally located to many restaurants and shops. Walkable location, friendly staff with prompt and polite service. Jorge and Lorenzo are wonderful!
Reviewed on 4 Aug 2025
Top hotels in Santi Cosma e Damiano

Hotel Mirasole International
Via Firenze, 5, Gaeta, LT
The price is €168 per night from 2 Sept to 3 Sept
€168
2 Sept - 3 Sept
includes taxes & fees
8.4/10 Very Good! (275 reviews)
"Fantastic hotel. Great access to beach and great pool. Staff could not have benn any better. They were excellent."
Reviewed on 19 Jul 2025

Grand Hotel Le Rocce
Via Flacca Km 23, Gaeta, LT
The price is €447 per night from 1 Sept to 2 Sept
€447
1 Sept - 2 Sept
includes taxes & fees
9.6/10 Exceptional! (48 reviews)
super
"very clean, excellent location, free parking free Wi-Fi Lovely breakfast"
Reviewed on 27 Jun 2025

Edra Palace
Via Ausonia angolo via Cerro, Cassino, FR
Fully refundableReserve now, pay when you stay
9/10 Wonderful! (149 reviews)
5 Star hotel
"5Star throughout. Highly recommend. Even the gym was better than expected."
Reviewed on 28 Jul 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
More trip options
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.